Team Info
San Francisco 49ers
Levi's Stadium - Santa Clara, CA
Owner Jed York
General Manager John Lynch
City Santa Clara, CA
Stadium Levi's Stadium
Head Coach Kyle Shanahan
Offensive Coordinator Klay Kubiak
Defensive Coordinator Raheem Morris
Special Teams Coordinator Brant Boyer
Starters
56
97
53
54
57
2
0
27
36
94
13
23
71
75
64
77
68
5
19
84
85
11 Personnel (Double Wing R) vs 4-3
Depth Chart
Injury Report
| 2009 | 1 | Ahmad Brooks | LB | Knee | Out |
| 2009 | 1 | Brandon Jones | WR | Shoulder | Out |
| 2009 | 2 | Ahmad Brooks | LB | Knee | Out |
| 2009 | 2 | Brandon Jones | WR | Shoulder | Doubtful |
| 2009 | 2 | David Baas | G | Biceps | Probable |
| 2009 | 2 | Aubrayo Franklin | DT | Shin | Probable |
| 2009 | 2 | Marcus Hudson | CB | Knee | Probable |
| 2009 | 2 | Chilo Rachal | G | Neck | Probable |
| 2009 | 2 | Justin Smith | DE | Elbow | Probable |
| 2009 | 2 | Isaac Sopoaga | DE | Shoulder | Probable |
| 2009 | 3 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 3 | Justin Smith | DE | Not Injury Related | — |
| 2009 | 3 | Marques Harris | LB | Toe | Questionable |
| 2009 | 3 | David Baas | G | Ankle | Probable |
| 2009 | 3 | Ahmad Brooks | LB | Knee | Probable |
| 2009 | 3 | Glen Coffee | RB | Hip | Probable |
| 2009 | 3 | Frank Gore | RB | Ankle | Probable |
| 2009 | 4 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 4 | Justin Smith | DE | Not Injury Related | — |
| 2009 | 4 | Allen Rossum | CB | Illness | — |
| 2009 | 4 | Frank Gore | RB | Ankle / Foot | Out |
| 2009 | 4 | Reggie Smith | S | Groin | Out |
| 2009 | 4 | David Baas | G | Ankle | Probable |
| 2009 | 4 | Vernon Davis | TE | Shin | Probable |
| 2009 | 4 | Adam Snyder | T | Thumb | Probable |
| 2009 | 4 | Shawntae Spencer | CB | Shoulder | Probable |
| 2009 | 4 | Takeo Spikes | LB | Shin | Probable |
| 2009 | 4 | Joe Staley | T | Thigh | Probable |
| 2009 | 4 | Jeff Ulbrich | LB | Thigh | Probable |
| 2009 | 5 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 5 | Justin Smith | DE | Not Injury Related | — |
| 2009 | 5 | Frank Gore | RB | Foot / Ankle | Out |
| 2009 | 5 | Reggie Smith | S | Groin | Out |
| 2009 | 5 | Jeff Ulbrich | LB | Concussion | Out |
| 2009 | 5 | Marques Harris | LB | Hamstring | Questionable |
| 2009 | 5 | David Baas | G | Ankle | Probable |
| 2009 | 5 | Arnaz Battle | WR | Hand | Probable |
| 2009 | 5 | Manny Lawson | LB | Illness | Probable |
| 2009 | 5 | Allen Rossum | CB | Back | Probable |
| 2009 | 5 | Patrick Willis | LB | Abdomen | Probable |
| 2009 | 7 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 7 | Nate Davis | QB | Illness | Out |
| 2009 | 7 | Michael Lewis | S | Concussion | Out |
| 2009 | 7 | Reggie Smith | S | Groin | Out |
| 2009 | 7 | Tarell Brown | CB | Illness | Probable |
| 2009 | 7 | Frank Gore | RB | Ankle / Foot | Probable |
| 2009 | 7 | Marcus Hudson | CB | Shoulder | Probable |
| 2009 | 7 | Ray McDonald | DE | Ankle | Probable |
| 2009 | 8 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 8 | Reggie Smith | S | Groin | Doubtful |
| 2009 | 8 | Ray McDonald | DE | Ankle | Questionable |
| 2009 | 8 | Takeo Spikes | LB | Shoulder | Questionable |
| 2009 | 8 | Marcus Hudson | CB | Shoulder | Probable |
| 2009 | 8 | Michael Robinson | RB | Shoulder | Probable |
| 2009 | 8 | Adam Snyder | T | Calf | Probable |
| 2009 | 9 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 9 | Justin Smith | DE | Not Injury Related | — |
| 2009 | 9 | Nate Clements | CB | Shoulder | Out |
| 2009 | 9 | Demetric Evans | DE | Shoulder | Out |
| 2009 | 9 | Joe Staley | T | Knee | Out |
| 2009 | 9 | Reggie Smith | S | Groin | Probable |
| 2009 | 9 | Takeo Spikes | LB | Shoulder | Probable |
| 2009 | 10 | Justin Smith | DE | Not Injury Related | — |
| 2009 | 10 | Nate Clements | CB | Shoulder | Out |
| 2009 | 10 | Glen Coffee | RB | Concussion | Out |
| 2009 | 10 | Demetric Evans | DT | Shoulder | Out |
| 2009 | 10 | Joe Staley | T | Knee | Out |
| 2009 | 10 | Isaac Bruce | WR | Ankle | Questionable |
| 2009 | 10 | David Baas | G | Shoulder | Probable |
| 2009 | 10 | Tarell Brown | CB | Rib | Probable |
| 2009 | 10 | Vernon Davis | TE | Shoulder | Probable |
| 2009 | 10 | Frank Gore | RB | Eye Lid | Probable |
| 2009 | 10 | Jason Hill | WR | Ankle | Probable |
| 2009 | 10 | Brandon Jones | WR | Knee | Probable |
| 2009 | 10 | Michael Lewis | S | Quadricep | Probable |
| 2009 | 10 | Michael Robinson | RB | Shoulder | Probable |
| 2009 | 10 | Takeo Spikes | LB | Shoulder | Probable |
| 2009 | 10 | Curtis Taylor | S | Shin | Probable |
| 2009 | 10 | Delanie Walker | TE | Shin / Knee | Probable |
| 2009 | 11 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 11 | Nate Clements | CB | Shoulder | Out |
| 2009 | 11 | Joe Staley | T | Knee | Out |
| 2009 | 11 | Takeo Spikes | LB | Hamstring | Questionable |
| 2009 | 11 | Michael Robinson | RB | Not Injury Related | Probable |
| 2009 | 11 | Isaac Bruce | WR | Ankle / Elbow | Probable |
| 2009 | 11 | Glen Coffee | RB | Concussion | Probable |
| 2009 | 11 | Michael Crabtree | WR | Knee | Probable |
| 2009 | 11 | Demetric Evans | DT | Shoulder | Probable |
| 2009 | 11 | Michael Lewis | S | Quadricep | Probable |
| 2009 | 11 | Mark Roman | S | Knee | Probable |
| 2009 | 11 | Justin Smith | DT | Back | Probable |
| 2009 | 11 | Adam Snyder | T | Shoulder | Probable |
| 2009 | 12 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 12 | Mark Roman | S | Illness | — |
| 2009 | 12 | Justin Smith | DT | Not Injury Related | — |
| 2009 | 12 | Nate Clements | CB | Shoulder | Out |
| 2009 | 12 | Joe Staley | T | Knee | Out |
| 2009 | 12 | Isaac Bruce | WR | Ankle | Doubtful |
| 2009 | 12 | Michael Robinson | RB | Shoulder | Doubtful |
| 2009 | 12 | Arnaz Battle | WR | Ankle | Questionable |
| 2009 | 12 | Takeo Spikes | LB | Hamstring | Questionable |
| 2009 | 12 | David Baas | G | Ankle | Probable |
| 2009 | 12 | Tarell Brown | CB | Knee | Probable |
| 2009 | 12 | Marcus Hudson | CB | Back | Probable |
| 2009 | 12 | Reggie Smith | S | Abdomen | Probable |
| 2009 | 12 | Adam Snyder | T | Shoulder | Probable |
| 2009 | 12 | Curtis Taylor | S | Knee | Probable |
| 2009 | 12 | Patrick Willis | LB | Shoulder | Probable |
| 2009 | 12 | Michael Lewis | S | Quadricep | Probable |
| 2009 | 13 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 13 | Mark Roman | S | Not Injury Related | — |
| 2009 | 13 | Justin Smith | DT | Not Injury Related | — |
| 2009 | 13 | Nate Clements | CB | Shoulder | Out |
| 2009 | 13 | Joe Staley | T | Knee | Doubtful |
| 2009 | 13 | Kentwan Balmer | DT | Shoulder | Doubtful |
| 2009 | 13 | Isaac Bruce | WR | Ankle | Questionable |
| 2009 | 13 | Marcus Hudson | CB | Back | Questionable |
| 2009 | 13 | Takeo Spikes | LB | Hamstring | Questionable |
| 2009 | 13 | Arnaz Battle | WR | Ankle | Probable |
| 2009 | 13 | Ahmad Brooks | LB | Thumb | Probable |
| 2009 | 13 | Brandon Jones | WR | Thumb | Probable |
| 2009 | 13 | Michael Lewis | S | Quadricep | Probable |
| 2009 | 13 | Ray McDonald | DT | Shoulder | Probable |
| 2009 | 13 | Michael Robinson | RB | Shoulder | Probable |
| 2009 | 13 | Adam Snyder | T | Shoulder | Probable |
| 2009 | 14 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 14 | Justin Smith | DT | Not Injury Related | — |
| 2009 | 14 | Nate Clements | CB | Shoulder | Out |
| 2009 | 14 | Isaac Bruce | WR | Ankle | Doubtful |
| 2009 | 14 | Marcus Hudson | CB | Back | Questionable |
| 2009 | 14 | Takeo Spikes | LB | Hamstring | Questionable |
| 2009 | 14 | Joe Staley | T | Knee | Questionable |
| 2009 | 14 | Brandon Jones | WR | Thumb | Probable |
| 2009 | 14 | Michael Lewis | S | Quadricep | Probable |
| 2009 | 15 | Nate Clements | CB | Shoulder | Out |
| 2009 | 15 | Isaac Bruce | WR | Ankle | Doubtful |
| 2009 | 15 | Barry Sims | T | Knee | Questionable |
| 2009 | 15 | Delanie Walker | TE | Ankle | Questionable |
| 2009 | 15 | Ahmad Brooks | LB | Foot | Probable |
| 2009 | 15 | Dashon Goldson | S | Chest | Probable |
| 2009 | 15 | Frank Gore | RB | Toe | Probable |
| 2009 | 15 | Marcus Hudson | CB | Back | Probable |
| 2009 | 15 | Moran Norris | RB | Toe | Probable |
| 2009 | 15 | Michael Robinson | RB | Shoulder | Probable |
| 2009 | 15 | Takeo Spikes | LB | Hamstring | Probable |
| 2009 | 15 | Joe Staley | T | Knee | Probable |
| 2009 | 16 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 16 | Justin Smith | DE | Not Injury Related | — |
| 2009 | 16 | Nate Clements | CB | Shoulder | Out |
| 2009 | 16 | Joe Nedney | K | left Hamstring | Out |
| 2009 | 16 | Isaac Bruce | WR | Ankle | Doubtful |
| 2009 | 16 | Glen Coffee | RB | Hamstring | Doubtful |
| 2009 | 16 | Marcus Hudson | CB | Back | Probable |
| 2009 | 16 | Moran Norris | RB | Toe | Probable |
| 2009 | 16 | Michael Robinson | RB | Shoulder | Probable |
| 2009 | 16 | Takeo Spikes | LB | Hamstring | Probable |
| 2009 | 16 | Joe Staley | T | Knee / Elbow | Probable |
| 2009 | 16 | Shawntae Spencer | CB | Ankle | Probable |
| 2009 | 17 | Aubrayo Franklin | DT | Not Injury Related | — |
| 2009 | 17 | Justin Smith | DT | Not Injury Related | — |
| 2009 | 17 | Joe Nedney | K | left Hamstring | Out |
| 2009 | 17 | Nate Clements | CB | Shoulder | Out |
| 2009 | 17 | Isaac Bruce | WR | Ankle | Questionable |
| 2009 | 17 | Ricky Schmitt | K | left Groin | Questionable |
| 2009 | 17 | Joe Staley | T | Knee | Questionable |
| 2009 | 17 | Glen Coffee | RB | Thigh | Probable |
| 2009 | 17 | Chilo Rachal | G | Knee | Probable |
| 2009 | 17 | Shaun Hill | QB | Back | Probable |
| 2010 | 1 | Ahmad Brooks | LB | Lacerated Kidney | Out |
| 2010 | 1 | Eric Heitmann | C | Fibula | Out |
| 2010 | 1 | Kyle Williams | WR | Toe | Out |
| 2010 | 1 | William James | CB | Ankle | Doubtful |
| 2010 | 1 | Diyral Briggs | LB | Concussion | Probable |
| 2010 | 2 | Delanie Walker | TE | Not Injury Related | — |
| 2010 | 2 | Eric Heitmann | C | Fibula | Out |
| 2010 | 2 | Ted Ginn | WR | Knee | Doubtful |
| 2010 | 2 | William James | CB | Ankle | Doubtful |
| 2010 | 2 | Chilo Rachal | G | Stinger | Doubtful |
| 2010 | 2 | Kyle Williams | WR | Toe | Doubtful |
| 2010 | 2 | Phillip Adams | CB | Hamstring | Questionable |
| 2010 | 2 | Alex Boone | T | Calf | Probable |
| 2010 | 2 | Ahmad Brooks | LB | Elbow | Probable |
| 2010 | 2 | Adam Snyder | G | Illness | Probable |
| 2010 | 2 | Patrick Willis | LB | Knee / Thumb | Probable |
| 2010 | 3 | Adam Snyder | G | Not Injury Related | — |
| 2010 | 3 | Eric Heitmann | C | Fibula | Out |
| 2010 | 3 | Ted Ginn | WR | Knee | Doubtful |
| 2010 | 3 | William James | CB | Ankle | Doubtful |
| 2010 | 3 | Takeo Spikes | LB | Knee | Questionable |
| 2010 | 3 | Anthony Dixon | RB | Back | Probable |
| 2010 | 4 | Ted Ginn | WR | Knee | Doubtful |
| 2010 | 4 | Eric Heitmann | C | Fibula | Doubtful |
| 2010 | 4 | William James | CB | Ankle | Questionable |
| 2010 | 4 | Michael Lewis | WR | Ankle / Not Injury Related | Probable |
| 2010 | 4 | Dashon Goldson | S | Knee / Foot | Probable |
| 2010 | 4 | Takeo Spikes | LB | Knee | Probable |
| 2010 | 5 | Delanie Walker | TE | Ankle | Out |
| 2010 | 5 | Kyle Williams | WR | Finger | Questionable |
| 2010 | 5 | Chilo Rachal | G | Knee | Probable |
| 2010 | 6 | Curtis Taylor | S | Quadricep | Out |
| 2010 | 6 | Delanie Walker | TE | Ankle | Out |
| 2010 | 6 | Joe Staley | T | Shoulder | Probable |
| 2010 | 6 | Troy Smith | QB | Abdomen | Probable |
| 2010 | 6 | Adam Snyder | G | Quadricep | Probable |
| 2010 | 7 | David Baas | C | Not Injury Related | — |
| 2010 | 7 | Eric Heitmann | C | Neck | Out |
| 2010 | 7 | Nate Clements | CB | Ankle | Questionable |
| 2010 | 7 | Delanie Walker | TE | Ankle | Questionable |
| 2010 | 7 | Vernon Davis | TE | Knee | Probable |
| 2010 | 7 | Parys Haralson | LB | Calf | Probable |
| 2010 | 7 | Manny Lawson | LB | Rib | Probable |
| 2010 | 7 | Josh Morgan | WR | Thigh | Probable |
| 2010 | 7 | Justin Smith | DT | Hand | Probable |
| 2010 | 8 | Eric Heitmann | C | Neck | Out |
| 2010 | 8 | Alex Smith | QB | left Shoulder | Out |
| 2010 | 8 | Tarell Brown | CB | Back | Doubtful |
| 2010 | 8 | Vernon Davis | TE | Ankle | Questionable |
| 2010 | 8 | Anthony Dixon | RB | Hamstring | Questionable |
| 2010 | 8 | Ahmad Brooks | LB | Knee | Probable |
| 2010 | 8 | Nate Clements | CB | Ankle | Probable |
| 2010 | 8 | Adam Snyder | G | Back | Probable |
| 2010 | 10 | Alex Smith | QB | left Shoulder | Out |
| 2010 | 10 | Chilo Rachal | G | Not Injury Related | Probable |
| 2010 | 10 | Nate Clements | CB | Ankle | Probable |
| 2010 | 11 | Joe Nedney | K | right Knee | Out |
| 2010 | 11 | Joe Staley | T | Fibula | Out |
| 2010 | 11 | William James | CB | Concussion | Doubtful |
| 2010 | 11 | Nate Clements | CB | Quadricep | Probable |
| 2010 | 11 | Frank Gore | RB | Foot | Probable |
| 2010 | 11 | Adam Snyder | G | Shoulder | Probable |
| 2010 | 12 | Joe Staley | T | Fibula | Out |
| 2010 | 12 | William James | CB | Concussion | Doubtful |
| 2010 | 12 | Joe Nedney | K | right Knee | Doubtful |
| 2010 | 12 | Dashon Goldson | S | Ankle | Questionable |
| 2010 | 12 | Nate Clements | CB | Ankle | Probable |
| 2010 | 12 | Vernon Davis | TE | Ankle | Probable |
| 2010 | 12 | Anthony Davis | T | Ankle | Probable |
| 2010 | 12 | Frank Gore | RB | Ankle | Probable |
| 2010 | 12 | Josh Morgan | WR | Shoulder | Probable |
| 2010 | 13 | Joe Nedney | K | right Knee | Out |
| 2010 | 13 | Joe Staley | T | Fibula | Out |
| 2010 | 13 | William James | CB | Concussion | Doubtful |
| 2010 | 13 | Parys Haralson | LB | Ankle | Questionable |
| 2010 | 13 | David Baas | C | Concussion | Questionable |
| 2010 | 13 | Shawntae Spencer | CB | Quadricep | Questionable |
| 2010 | 13 | Josh Morgan | WR | Shoulder | Probable |
| 2010 | 13 | Brian Westbrook | RB | Ankle | Probable |
| 2010 | 14 | Joe Nedney | K | right Knee | Out |
| 2010 | 14 | Joe Staley | T | Fibula | Out |
| 2010 | 14 | William James | CB | Concussion | Doubtful |
| 2010 | 14 | DeShawn Wynn | RB | Ankle | Doubtful |
| 2010 | 14 | Aubrayo Franklin | DT | Groin | Questionable |
| 2010 | 14 | Nate Clements | CB | Knee | Questionable |
| 2010 | 14 | Parys Haralson | LB | Ankle | Questionable |
| 2010 | 14 | Anthony Davis | T | Back | Probable |
| 2010 | 14 | Shawntae Spencer | CB | Quadricep | Probable |
| 2010 | 14 | Takeo Spikes | LB | Ankle | Probable |
| 2010 | 14 | Brian Westbrook | RB | Not Injury Related | Probable |
| 2010 | 14 | Josh Morgan | WR | Shoulder | Probable |
| 2010 | 14 | Delanie Walker | TE | Ankle | Probable |
| 2010 | 15 | Joe Nedney | K | right Knee | Out |
| 2010 | 15 | Joe Staley | T | Fibula | Out |
| 2010 | 15 | Takeo Spikes | LB | Hand | Questionable |
| 2010 | 15 | Patrick Willis | LB | Hand | Questionable |
| 2010 | 15 | Navorro Bowman | LB | Hamstring | Questionable |
| 2010 | 15 | Nate Byham | TE | Shoulder | Probable |
| 2010 | 15 | Mike Iupati | G | Shoulder | Probable |
| 2010 | 15 | Brian Westbrook | RB | Not Injury Related | Probable |
| 2010 | 15 | DeShawn Wynn | RB | Ankle | Probable |
| 2010 | 16 | Nate Byham | TE | Heel | Out |
| 2010 | 16 | Joe Staley | T | Fibula | Out |
| 2010 | 16 | Anthony Dixon | RB | Ankle | Questionable |
| 2010 | 16 | Nate Clements | CB | Knee | Probable |
| 2010 | 16 | Josh Morgan | WR | Shoulder | Probable |
| 2010 | 16 | Brian Westbrook | RB | Not Injury Related | Probable |
| 2010 | 16 | DeShawn Wynn | RB | Ankle | Probable |
| 2010 | 16 | Takeo Spikes | LB | Hand | Probable |
| 2010 | 16 | Patrick Willis | LB | Hand | Probable |
| 2010 | 17 | Nate Byham | TE | Heel | Out |
| 2010 | 17 | Phillip Adams | CB | Ankle | Out |
| 2010 | 17 | Keaton Kristick | LB | Concussion | Out |
| 2010 | 17 | Joe Staley | T | Fibula | Out |
| 2010 | 17 | Patrick Willis | LB | Hand | Out |
| 2010 | 17 | Vernon Davis | TE | Thumb | Probable |
| 2010 | 17 | Anthony Dixon | RB | Ankle | Probable |
| 2010 | 17 | Justin Smith | DT | Illness | Probable |
| 2010 | 17 | Takeo Spikes | LB | Hand | Probable |
| 2010 | 17 | Brian Westbrook | RB | Not Injury Related | Probable |
| 2010 | 17 | David Baas | C | Ribs | Probable |
| 2011 | 1 | Dashon Goldson | S | Knee | Doubtful |
| 2011 | 2 | Michael Crabtree | WR | Feet | Questionable |
| 2011 | 2 | Dashon Goldson | S | Knee | Questionable |
| 2011 | 3 | Braylon Edwards | WR | Knee | Out |
| 2011 | 3 | Moran Norris | RB | Fibula | Out |
| 2011 | 3 | Tramaine Brock | CB | Hand | Probable |
| 2011 | 3 | Alex Smith | QB | Concussion | Probable |
| 2011 | 3 | Michael Crabtree | WR | Feet | Probable |
| 2011 | 4 | Braylon Edwards | WR | Knee | Out |
| 2011 | 4 | Moran Norris | RB | Fibula | Out |
| 2011 | 4 | Frank Gore | RB | Ankle | Questionable |
| 2011 | 4 | Donte Whitner | S | Hip | Questionable |
| 2011 | 4 | Mike Iupati | G | Neck | Probable |
| 2011 | 4 | Michael Crabtree | WR | Foot | Probable |
| 2011 | 5 | Tramaine Brock | CB | Hand | Out |
| 2011 | 5 | Braylon Edwards | WR | Knee | Out |
| 2011 | 5 | Moran Norris | RB | Fibula | Out |
| 2011 | 5 | Isaac Sopoaga | DT | Infection | Doubtful |
| 2011 | 5 | Shawntae Spencer | CB | Toe | Questionable |
| 2011 | 5 | Mike Iupati | G | Neck | Probable |
| 2011 | 5 | Adam Snyder | G | Hamstring | Probable |
| 2011 | 5 | Michael Crabtree | WR | Foot | Probable |
| 2011 | 5 | Frank Gore | RB | Ankle | Probable |
| 2011 | 6 | Tramaine Brock | CB | Hand | Out |
| 2011 | 6 | Braylon Edwards | WR | Knee | Out |
| 2011 | 6 | Moran Norris | RB | Fibula | Out |
| 2011 | 6 | Navorro Bowman | LB | Neck | Probable |
| 2011 | 6 | Ted Ginn | WR | Finger | Probable |
| 2011 | 6 | Michael Crabtree | WR | Feet | Probable |
| 2011 | 6 | Dashon Goldson | S | Knee | Probable |
| 2011 | 6 | Mike Iupati | G | Knee | Probable |
| 2011 | 6 | Adam Snyder | G | Forearm | Probable |
| 2011 | 6 | Isaac Sopoaga | DT | Infection | Probable |
| 2011 | 6 | Shawntae Spencer | CB | Toe | Probable |
| 2011 | 8 | Tramaine Brock | CB | Hand | Doubtful |
| 2011 | 8 | Moran Norris | RB | Fibula | Doubtful |
| 2011 | 8 | Braylon Edwards | WR | Knee | Questionable |
| 2011 | 8 | Parys Haralson | LB | Hamstring | Probable |
| 2011 | 8 | Adam Snyder | G | Stinger | Probable |
| 2011 | 8 | Shawntae Spencer | CB | Toe | Probable |
| 2011 | 8 | Michael Crabtree | WR | Foot | Probable |
| 2011 | 8 | Chris Culliver | CB | Shoulder | Probable |
| 2011 | 8 | Jonathan Goodwin | C | Concussion | Probable |
| 2011 | 9 | Justin Smith | DT | Not Injury Related | — |
| 2011 | 9 | Ray McDonald | DT | Hamstring | Doubtful |
| 2011 | 9 | Moran Norris | RB | Fibula | Questionable |
| 2011 | 9 | Tramaine Brock | CB | Hand | Probable |
| 2011 | 9 | Shawntae Spencer | CB | Toe | Probable |
| 2011 | 9 | Michael Crabtree | WR | Foot | Probable |
| 2011 | 9 | Chris Culliver | CB | Shoulder | Probable |
| 2011 | 9 | Braylon Edwards | WR | Knee | Probable |
| 2011 | 9 | Dashon Goldson | S | Knee | Probable |
| 2011 | 10 | Justin Smith | DT | Not Injury Related | — |
| 2011 | 10 | Ray McDonald | DT | Hamstring | Questionable |
| 2011 | 10 | Moran Norris | RB | Fibula | Questionable |
| 2011 | 10 | Dashon Goldson | S | Knee | Probable |
| 2011 | 10 | Kendall Hunter | RB | Ankle | Probable |
| 2011 | 10 | Shawntae Spencer | CB | Toe | Probable |
| 2011 | 10 | Delanie Walker | TE | Knee | Probable |
| 2011 | 10 | Donte Whitner | S | Thigh | Probable |
| 2011 | 10 | Navorro Bowman | LB | Shoulder | Probable |
| 2011 | 10 | Michael Crabtree | WR | Foot | Probable |
| 2011 | 10 | Chris Culliver | CB | Shoulder | Probable |
| 2011 | 10 | Braylon Edwards | WR | Knee | Probable |
| 2011 | 10 | Frank Gore | RB | Ankle | Probable |
| 2011 | 11 | Justin Smith | DT | Not Injury Related | — |
| 2011 | 11 | Tarell Brown | CB | Knee | Questionable |
| 2011 | 11 | Frank Gore | RB | Knee | Questionable |
| 2011 | 11 | Ray McDonald | DT | Hamstring | Questionable |
| 2011 | 11 | Shawntae Spencer | CB | Toe | Probable |
| 2011 | 11 | Navorro Bowman | LB | Neck | Probable |
| 2011 | 11 | Michael Crabtree | WR | Foot | Probable |
| 2011 | 11 | Chris Culliver | CB | Shoulder | Probable |
| 2011 | 11 | Braylon Edwards | WR | Knee | Probable |
| 2011 | 12 | Bruce Miller | RB | Concussion | Doubtful |
| 2011 | 12 | Michael Crabtree | WR | Foot | Probable |
| 2011 | 12 | Chris Culliver | CB | Shoulder | Probable |
| 2011 | 12 | Anthony Davis | T | Ankle | Probable |
| 2011 | 12 | Braylon Edwards | WR | Knee | Probable |
| 2011 | 12 | Frank Gore | RB | Knee | Probable |
| 2011 | 13 | Braylon Edwards | WR | Knee | Questionable |
| 2011 | 13 | Chris Culliver | CB | Shoulder | Probable |
| 2011 | 13 | Anthony Davis | T | Ankle | Probable |
| 2011 | 13 | Bruce Miller | RB | Concussion | Probable |
| 2011 | 13 | Adam Snyder | G | Hamstring | Probable |
| 2011 | 13 | Frank Gore | RB | Ankle | Probable |
| 2011 | 14 | Patrick Willis | LB | Hamstring | Questionable |
| 2011 | 14 | Tarell Brown | CB | Ankle | Questionable |
| 2011 | 14 | Braylon Edwards | WR | Knee | Questionable |
| 2011 | 14 | Carlos Rogers | CB | Knee | Questionable |
| 2011 | 15 | Patrick Willis | LB | Hamstring | Questionable |
| 2011 | 15 | Braylon Edwards | WR | Knee | Questionable |
| 2011 | 15 | Bruce Miller | RB | Knee | Questionable |
| 2011 | 15 | Joe Staley | T | Concussion | Questionable |
| 2011 | 16 | Blake Costanzo | LB | Not Injury Related | — |
| 2011 | 16 | Ted Ginn | WR | Ankle | Questionable |
| 2011 | 16 | Braylon Edwards | WR | Knee | Questionable |
| 2011 | 16 | Bruce Miller | RB | Knee | Questionable |
| 2011 | 16 | Patrick Willis | LB | Hamstring | Questionable |
| 2011 | 17 | Delanie Walker | TE | Jaw | Out |
| 2011 | 17 | Ted Ginn | WR | Ankle | Questionable |
| 2011 | 17 | Kyle Williams | WR | Concussion | Questionable |
| 2011 | 17 | Chris Culliver | CB | Shoulder | Questionable |
| 2011 | 17 | Bruce Miller | RB | Knee | Questionable |
| 2011 | 17 | Carlos Rogers | CB | Knee | Questionable |
| 2011 | 17 | Patrick Willis | LB | Hamstring | Questionable |
| 2011 | 19 (DIV) | Chris Culliver | CB | Knee / Illness | Questionable |
| 2011 | 19 (DIV) | Delanie Walker | TE | Jaw | Questionable |
| 2011 | 19 (DIV) | Ted Ginn | WR | Ankle | Questionable |
| 2011 | 19 (DIV) | Ray McDonald | DT | Hamstring | Questionable |
| 2011 | 19 (DIV) | Kyle Williams | WR | Concussion | Questionable |
| 2011 | 20 (CONF) | Ted Ginn | WR | Knee | Questionable |
| 2011 | 20 (CONF) | Tarell Brown | CB | Thigh | Questionable |
| 2011 | 20 (CONF) | Dashon Goldson | S | Ankle | Questionable |
| 2011 | 20 (CONF) | Jonathan Goodwin | C | Calf | Questionable |
| 2011 | 20 (CONF) | Delanie Walker | TE | Jaw | Questionable |
| 2011 | 20 (CONF) | Patrick Willis | LB | Knee | Questionable |
| 2012 | 1 | Ted Ginn | WR | Ankle | Questionable |
| 2012 | 1 | Brandon Jacobs | RB | Knee | Questionable |
| 2012 | 2 | Ted Ginn | WR | Ankle | Questionable |
| 2012 | 2 | Brandon Jacobs | RB | Knee | Questionable |
| 2012 | 2 | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 2 | Andy Lee | P | Hand | Probable |
| 2012 | 3 | Brandon Jacobs | RB | Knee | Questionable |
| 2012 | 3 | Ted Ginn | WR | Ankle | Questionable |
| 2012 | 3 | Andy Lee | P | Hand | Probable |
| 2012 | 4 | Isaac Sopoaga | DT | Ankle / Knee | Questionable |
| 2012 | 4 | Ted Ginn | WR | Ankle | Questionable |
| 2012 | 4 | Brandon Jacobs | RB | Knee | Questionable |
| 2012 | 4 | Vernon Davis | TE | Back | Probable |
| 2012 | 4 | Andy Lee | P | Hand | Probable |
| 2012 | 4 | Patrick Willis | LB | Ankle | Probable |
| 2012 | 5 | Brandon Jacobs | RB | Knee | Questionable |
| 2012 | 5 | Carlos Rogers | CB | Ankle | Questionable |
| 2012 | 5 | Isaac Sopoaga | DT | Knee / Ankle | Questionable |
| 2012 | 5 | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 5 | Andy Lee | P | Hand | Probable |
| 2012 | 6 | Brandon Jacobs | RB | Knee | Questionable |
| 2012 | 6 | Andy Lee | P | Hand | Probable |
| 2012 | 6 | Alex Smith | QB | right Finger | Probable |
| 2012 | 7 | Brandon Jacobs | RB | Knee | Questionable |
| 2012 | 7 | Mario Manningham | WR | Shoulder | Questionable |
| 2012 | 7 | Joe Staley | T | Concussion | Questionable |
| 2012 | 7 | David Akers | K | Illness | Probable |
| 2012 | 7 | Tavares Gooden | LB | Elbow | Probable |
| 2012 | 7 | Andy Lee | P | Hand | Probable |
| 2012 | 7 | Alex Smith | QB | right Finger | Probable |
| 2012 | 8 | Joe Staley | T | Illness | Questionable |
| 2012 | 8 | Tavares Gooden | LB | Elbow | Probable |
| 2012 | 8 | Frank Gore | RB | Rib | Probable |
| 2012 | 8 | Andy Lee | P | Hand | Probable |
| 2012 | 8 | Mario Manningham | WR | Shoulder | Probable |
| 2012 | 8 | Alex Smith | QB | right Finger | Probable |
| 2012 | 10 | Michael Crabtree | WR | Illness | Probable |
| 2012 | 10 | Tavares Gooden | LB | Elbow | Probable |
| 2012 | 10 | Frank Gore | RB | Hand | Probable |
| 2012 | 10 | Daniel Kilgore | G | Concussion | Probable |
| 2012 | 10 | Andy Lee | P | Hand | Probable |
| 2012 | 10 | Mario Manningham | WR | Shoulder | Probable |
| 2012 | 10 | Alex Smith | QB | right Finger | Probable |
| 2012 | 10 | Will Tukuafu | DT | Wrist | Probable |
| 2012 | 10 | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 11 | Alex Smith | QB | Concussion | Questionable |
| 2012 | 11 | Anthony Dixon | RB | Hamstring | Probable |
| 2012 | 11 | Dashon Goldson | S | Ribs | Probable |
| 2012 | 11 | Tavares Gooden | LB | Elbow / Quadricep | Probable |
| 2012 | 11 | Jonathan Goodwin | C | Ankle | Probable |
| 2012 | 11 | Frank Gore | RB | Ribs / Wrist | Probable |
| 2012 | 11 | Mike Iupati | G | Quadricep | Probable |
| 2012 | 11 | Mario Manningham | WR | Shoulder | Probable |
| 2012 | 11 | Will Tukuafu | DT | Wrist | Probable |
| 2012 | 11 | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 11 | Chris Culliver | CB | Shoulder | Probable |
| 2012 | 12 | Alex Smith | QB | Concussion | Questionable |
| 2012 | 12 | Tavares Gooden | LB | Shin | Probable |
| 2012 | 12 | Frank Gore | RB | Wrist / Ribs | Probable |
| 2012 | 12 | Randy Moss | WR | Finger | Probable |
| 2012 | 12 | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 12 | C.J. Spillman | S | Finger | Probable |
| 2012 | 12 | Will Tukuafu | DT | Wrist / Wrist | Probable |
| 2012 | 12 | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 12 | Tarell Brown | CB | Knee | Probable |
| 2012 | 12 | Chris Culliver | CB | Shoulder | Probable |
| 2012 | 12 | Dashon Goldson | S | Ribs / Calf | Probable |
| 2012 | 13 | Demarcus Dobbs | TE | Not Injury Related | Out |
| 2012 | 13 | Darcel McBath | S | Concussion | Questionable |
| 2012 | 13 | Tarell Brown | CB | Knee | Probable |
| 2012 | 13 | Anthony Davis | T | Finger | Probable |
| 2012 | 13 | Dashon Goldson | S | Ribs / Calf | Probable |
| 2012 | 13 | Tavares Gooden | LB | Elbow | Probable |
| 2012 | 13 | Frank Gore | RB | Wrist / Ribs | Probable |
| 2012 | 13 | Mario Manningham | WR | Shoulder | Probable |
| 2012 | 13 | Delanie Walker | TE | Hip / Ribs | Probable |
| 2012 | 13 | Donte Whitner | S | Knee | Probable |
| 2012 | 13 | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 13 | David Akers | K | Pelvis | Probable |
| 2012 | 13 | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 14 | Mario Manningham | WR | Shoulder | Doubtful |
| 2012 | 14 | David Akers | K | Pelvis | Probable |
| 2012 | 14 | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 14 | Tarell Brown | CB | Hamstring | Probable |
| 2012 | 14 | Chris Culliver | CB | Illness | Probable |
| 2012 | 14 | Tavares Gooden | LB | Knee / Elbow | Probable |
| 2012 | 14 | Frank Gore | RB | Wrist | Probable |
| 2012 | 14 | Mike Iupati | G | Shoulder | Probable |
| 2012 | 14 | Carlos Rogers | CB | Knee | Probable |
| 2012 | 14 | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 14 | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 15 | Mario Manningham | WR | Shoulder | Doubtful |
| 2012 | 15 | David Akers | K | Pelvis | Probable |
| 2012 | 15 | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 15 | Tarell Brown | CB | Shoulder | Probable |
| 2012 | 15 | Chris Culliver | CB | Knee | Probable |
| 2012 | 15 | Frank Gore | RB | Wrist | Probable |
| 2012 | 15 | Carlos Rogers | CB | Knee | Probable |
| 2012 | 15 | Will Tukuafu | DT | Wrist | Probable |
| 2012 | 15 | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 15 | Tavares Gooden | LB | Ribs | Probable |
| 2012 | 15 | Bruce Miller | RB | Shoulder | Probable |
| 2012 | 15 | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 16 | Clark Haggans | LB | Shoulder | Questionable |
| 2012 | 16 | Justin Smith | DT | Elbow | Questionable |
| 2012 | 16 | Tavares Gooden | LB | Ribs | Questionable |
| 2012 | 16 | Mario Manningham | WR | Shoulder | Questionable |
| 2012 | 16 | Will Tukuafu | DT | Concussion | Questionable |
| 2012 | 16 | C.J. Spillman | S | Illness | Probable |
| 2012 | 16 | David Akers | K | Pelvis | Probable |
| 2012 | 16 | Alex Boone | G | Knee | Probable |
| 2012 | 16 | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 16 | Dashon Goldson | S | Foot | Probable |
| 2012 | 16 | Frank Gore | RB | Wrist | Probable |
| 2012 | 16 | Mike Iupati | G | Shoulder | Probable |
| 2012 | 16 | Carlos Rogers | CB | Knee | Probable |
| 2012 | 16 | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 16 | Ahmad Brooks | LB | Shoulder | Probable |
| 2012 | 16 | Tarell Brown | CB | Shoulder | Probable |
| 2012 | 16 | Bruce Miller | RB | Shoulder | Probable |
| 2012 | 16 | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 17 | Mario Manningham | WR | Knee | — |
| 2012 | 17 | Justin Smith | DT | Elbow / Triceps | Doubtful |
| 2012 | 17 | Vernon Davis | TE | Concussion | Questionable |
| 2012 | 17 | Clark Haggans | LB | Shoulder | Questionable |
| 2012 | 17 | Will Tukuafu | DT | Neck | Questionable |
| 2012 | 17 | Navorro Bowman | LB | Wrist / Shoulder | Probable |
| 2012 | 17 | Jonathan Goodwin | C | Illness | Probable |
| 2012 | 17 | Frank Gore | RB | Knee | Probable |
| 2012 | 17 | Mike Iupati | G | Shoulder | Probable |
| 2012 | 17 | Andy Lee | P | Illness | Probable |
| 2012 | 17 | Trenton Robinson | S | Finger | Probable |
| 2012 | 17 | Carlos Rogers | CB | Knee / Toe | Probable |
| 2012 | 17 | Donte Whitner | S | Knee | Probable |
| 2012 | 17 | Ahmad Brooks | LB | Shoulder | Probable |
| 2012 | 17 | Tarell Brown | CB | Shoulder / Knee | Probable |
| 2012 | 17 | Tavares Gooden | LB | Illness / Rib | Probable |
| 2012 | 17 | Bruce Miller | RB | Shoulder | Probable |
| 2012 | 17 | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 19 (DIV) | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 19 (DIV) | Garrett Celek | TE | Foot | Probable |
| 2012 | 19 (DIV) | Tavares Gooden | LB | Ribs | Probable |
| 2012 | 19 (DIV) | Mike Iupati | G | Shoulder | Probable |
| 2012 | 19 (DIV) | Carlos Rogers | CB | Knee | Probable |
| 2012 | 19 (DIV) | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 19 (DIV) | Tarell Brown | CB | Shoulder | Probable |
| 2012 | 19 (DIV) | Dashon Goldson | S | Shoulder | Probable |
| 2012 | 19 (DIV) | Clark Haggans | LB | Shoulder | Probable |
| 2012 | 19 (DIV) | Bruce Miller | RB | Shoulder | Probable |
| 2012 | 19 (DIV) | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 19 (DIV) | Justin Smith | DT | Elbow / triceps | Probable |
| 2012 | 19 (DIV) | Will Tukuafu | DT | Neck | Probable |
| 2012 | 20 (CONF) | Alex Boone | G | Knee | Probable |
| 2012 | 20 (CONF) | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 20 (CONF) | Garrett Celek | TE | Foot | Probable |
| 2012 | 20 (CONF) | Chris Culliver | CB | Knee | Probable |
| 2012 | 20 (CONF) | Dashon Goldson | S | Shin | Probable |
| 2012 | 20 (CONF) | Tavares Gooden | LB | Knee | Probable |
| 2012 | 20 (CONF) | Frank Gore | RB | Knee | Probable |
| 2012 | 20 (CONF) | Clark Haggans | LB | Shoulder | Probable |
| 2012 | 20 (CONF) | Mike Iupati | G | Shoulder | Probable |
| 2012 | 20 (CONF) | Justin Smith | DT | Elbow / triceps | Probable |
| 2012 | 20 (CONF) | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 20 (CONF) | Tarell Brown | CB | Shoulder | Probable |
| 2012 | 20 (CONF) | Bruce Miller | RB | Shoulder | Probable |
| 2012 | 20 (CONF) | Aldon Smith | LB | Shoulder | Probable |
| 2012 | 21 (SB) | Navorro Bowman | LB | Shoulder | Probable |
| 2012 | 21 (SB) | Tarell Brown | CB | Shoulder | Probable |
| 2012 | 21 (SB) | Garrett Celek | TE | Foot | Probable |
| 2012 | 21 (SB) | Dashon Goldson | S | Foot | Probable |
| 2012 | 21 (SB) | Frank Gore | RB | Shoulder / Ankle | Probable |
| 2012 | 21 (SB) | Clark Haggans | LB | Shoulder | Probable |
| 2012 | 21 (SB) | Mike Iupati | G | Shoulder | Probable |
| 2012 | 21 (SB) | LaMichael James | RB | Finger | Probable |
| 2012 | 21 (SB) | Bruce Miller | RB | Shoulder | Probable |
| 2012 | 21 (SB) | Justin Smith | DT | Elbow / Triceps | Probable |
| 2012 | 21 (SB) | Patrick Willis | LB | Shoulder | Probable |
| 2012 | 21 (SB) | Ahmad Brooks | LB | Shoulder | Probable |
| 2012 | 21 (SB) | Aldon Smith | LB | Shoulder | Probable |
| 2013 | 1 | LaMichael James | RB | Knee | Questionable |
| 2013 | 1 | Nnamdi Asomugha | CB | Collarbone | Questionable |
| 2013 | 2 | LaMichael James | RB | Knee | Questionable |
| 2013 | 3 | Vernon Davis | TE | Hamstring | Questionable |
| 2013 | 3 | LaMichael James | RB | Knee | Questionable |
| 2013 | 3 | Ray McDonald | DT | Ankle / Ankle | Questionable |
| 2013 | 3 | Eric Reid | S | Concussion | Questionable |
| 2013 | 3 | Mike Iupati | G | Shoulder | Probable |
| 2013 | 3 | Colin Kaepernick | QB | Foot | Probable |
| 2013 | 3 | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 3 | Aldon Smith | LB | Back | Probable |
| 2013 | 3 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 4 | Nnamdi Asomugha | CB | Knee | Questionable |
| 2013 | 4 | Patrick Willis | LB | Groin | Questionable |
| 2013 | 4 | Anthony Davis | T | Shoulder | Questionable |
| 2013 | 4 | Vernon Davis | TE | Hamstring | Questionable |
| 2013 | 4 | Raymond Ventrone | S | Concussion | Questionable |
| 2013 | 4 | Kyle Williams | WR | Rib / Knee | Questionable |
| 2013 | 4 | Frank Gore | RB | Knee | Probable |
| 2013 | 4 | Mike Iupati | G | Shoulder | Probable |
| 2013 | 4 | Carlos Rogers | CB | Knee | Probable |
| 2013 | 4 | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 4 | Jonathan Goodwin | C | Elbow | Probable |
| 2013 | 4 | Ray McDonald | DT | Ankle / Ankle | Probable |
| 2013 | 4 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 5 | Quinton Patton | WR | Foot | Out |
| 2013 | 5 | Nnamdi Asomugha | CB | Knee | Questionable |
| 2013 | 5 | Vernon Davis | TE | Hamstring | Questionable |
| 2013 | 5 | Anthony Davis | T | Shoulder | Questionable |
| 2013 | 5 | Ray McDonald | DT | Ankle / Ankle | Questionable |
| 2013 | 5 | Bruce Miller | RB | Quadricep | Questionable |
| 2013 | 5 | Carlos Rogers | CB | Knee | Questionable |
| 2013 | 5 | Justin Smith | DT | Shoulder | Questionable |
| 2013 | 5 | Patrick Willis | LB | Groin | Questionable |
| 2013 | 5 | Demarcus Dobbs | TE | Calf | Probable |
| 2013 | 5 | Mike Iupati | G | Shoulder | Probable |
| 2013 | 5 | Joe Staley | T | Hamstring / Ankle | Probable |
| 2013 | 5 | Kyle Williams | WR | Knee | Probable |
| 2013 | 6 | Quinton Patton | WR | Foot | Out |
| 2013 | 6 | Jonathan Goodwin | C | Illness | Questionable |
| 2013 | 6 | Nnamdi Asomugha | CB | Knee | Questionable |
| 2013 | 6 | Alex Boone | G | Shoulder | Questionable |
| 2013 | 6 | Anthony Davis | T | Shoulder | Questionable |
| 2013 | 6 | Ray McDonald | DT | Biceps | Questionable |
| 2013 | 6 | Carlos Rogers | CB | Knee | Questionable |
| 2013 | 6 | Justin Smith | DT | Shoulder | Questionable |
| 2013 | 6 | Patrick Willis | LB | Groin | Questionable |
| 2013 | 6 | Vernon Davis | TE | Hamstring | Probable |
| 2013 | 6 | Frank Gore | RB | Knee | Probable |
| 2013 | 6 | Mike Iupati | G | Shoulder | Probable |
| 2013 | 6 | Colin Kaepernick | QB | Foot | Probable |
| 2013 | 6 | Marlon Moore | WR | Quadricep | Probable |
| 2013 | 6 | Joe Staley | T | Knee | Probable |
| 2013 | 6 | Kyle Williams | WR | Knee | Probable |
| 2013 | 7 | Quinton Patton | WR | Foot | Out |
| 2013 | 7 | Jon Baldwin | WR | Illness | Questionable |
| 2013 | 7 | Glenn Dorsey | DT | Hamstring | Questionable |
| 2013 | 7 | Ray McDonald | DT | Biceps | Questionable |
| 2013 | 7 | Carlos Rogers | CB | Knee | Questionable |
| 2013 | 7 | Justin Smith | DT | Shoulder | Questionable |
| 2013 | 7 | Ahmad Brooks | LB | Not Injury Related | Probable |
| 2013 | 7 | Alex Boone | G | Shoulder | Probable |
| 2013 | 7 | Tarell Brown | CB | Knee | Probable |
| 2013 | 7 | Vernon Davis | TE | Hamstring | Probable |
| 2013 | 7 | Anthony Davis | T | Shoulder | Probable |
| 2013 | 7 | Mike Iupati | G | Stinger | Probable |
| 2013 | 7 | Colin Kaepernick | QB | Foot | Probable |
| 2013 | 7 | Eric Reid | S | Hip / Ankle | Probable |
| 2013 | 7 | Michael Wilhoite | LB | Quadricep / Ankle | Probable |
| 2013 | 7 | Patrick Willis | LB | Groin | Probable |
| 2013 | 8 | Quinton Patton | WR | Foot | Out |
| 2013 | 8 | Ray McDonald | DT | Biceps | Questionable |
| 2013 | 8 | Jon Baldwin | WR | Illness | Questionable |
| 2013 | 8 | Glenn Dorsey | DT | Hamstring | Questionable |
| 2013 | 8 | Carlos Rogers | CB | Knee | Questionable |
| 2013 | 8 | Justin Smith | DT | Shoulder | Questionable |
| 2013 | 8 | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 8 | Vernon Davis | TE | Hamstring | Probable |
| 2013 | 8 | Anthony Davis | T | Shoulder | Probable |
| 2013 | 8 | Frank Gore | RB | Ankle | Probable |
| 2013 | 8 | Colin Kaepernick | QB | Foot | Probable |
| 2013 | 8 | Donte Whitner | S | Knee | Probable |
| 2013 | 8 | Kyle Williams | WR | Knee | Probable |
| 2013 | 8 | Patrick Willis | LB | Groin | Probable |
| 2013 | 8 | Alex Boone | G | Shoulder | Probable |
| 2013 | 10 | Quinton Patton | WR | Foot | Out |
| 2013 | 10 | Ahmad Brooks | LB | Stinger | Questionable |
| 2013 | 10 | Ray McDonald | DT | Biceps | Questionable |
| 2013 | 10 | Justin Smith | DT | Shoulder | Questionable |
| 2013 | 10 | Alex Boone | G | Shoulder | Probable |
| 2013 | 10 | Anthony Davis | T | Shoulder | Probable |
| 2013 | 10 | Quinton Dial | DT | Ankle | Probable |
| 2013 | 10 | Frank Gore | RB | Ankle | Probable |
| 2013 | 10 | Mike Iupati | G | Elbow | Probable |
| 2013 | 10 | Kyle Williams | WR | Knee | Probable |
| 2013 | 11 | Ray McDonald | DT | Ankle | Out |
| 2013 | 11 | Quinton Patton | WR | Foot | Out |
| 2013 | 11 | Garrett Celek | TE | Hamstring | Doubtful |
| 2013 | 11 | Vernon Davis | TE | Concussion | Questionable |
| 2013 | 11 | Mario Manningham | WR | Knee | Questionable |
| 2013 | 11 | Bruce Miller | RB | Hamstring | Questionable |
| 2013 | 11 | Eric Reid | S | Concussion | Questionable |
| 2013 | 11 | Dan Skuta | LB | Foot | Questionable |
| 2013 | 11 | Tarell Brown | CB | Knee | Probable |
| 2013 | 11 | Quinton Dial | DT | Ankle | Probable |
| 2013 | 11 | Frank Gore | RB | Ankle | Probable |
| 2013 | 11 | Mike Iupati | G | Knee | Probable |
| 2013 | 11 | Andy Lee | P | Neck | Probable |
| 2013 | 11 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 12 | Tarell Brown | CB | Ribs | Out |
| 2013 | 12 | Mike Iupati | G | Knee | Out |
| 2013 | 12 | Quinton Patton | WR | Foot | Out |
| 2013 | 12 | Garrett Celek | TE | Hamstring | Questionable |
| 2013 | 12 | Ray McDonald | DT | Ankle | Questionable |
| 2013 | 12 | Mario Manningham | WR | Knee | Questionable |
| 2013 | 12 | Quinton Dial | DT | Ankle | Probable |
| 2013 | 12 | Frank Gore | RB | Ankle | Probable |
| 2013 | 12 | Colin Kaepernick | QB | Back | Probable |
| 2013 | 12 | Dan Skuta | LB | Foot | Probable |
| 2013 | 12 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 13 | Tarell Brown | CB | Ribs | Questionable |
| 2013 | 13 | Garrett Celek | TE | Hamstring | Questionable |
| 2013 | 13 | Mike Iupati | G | Knee | Questionable |
| 2013 | 13 | Ray McDonald | DT | Ankle | Questionable |
| 2013 | 13 | Ahmad Brooks | LB | Stinger | Questionable |
| 2013 | 13 | Quinton Patton | WR | Foot | Questionable |
| 2013 | 13 | Aldon Smith | LB | Shoulder | Questionable |
| 2013 | 13 | Navorro Bowman | LB | Knee / Shoulder | Probable |
| 2013 | 13 | Frank Gore | RB | Ankle | Probable |
| 2013 | 13 | Dan Skuta | LB | Foot | Probable |
| 2013 | 13 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 13 | Mario Manningham | WR | Knee | Probable |
| 2013 | 14 | Mike Iupati | G | Knee | Questionable |
| 2013 | 14 | Jon Baldwin | WR | Calf | Questionable |
| 2013 | 14 | Tarell Brown | CB | Ribs | Questionable |
| 2013 | 14 | Mario Manningham | WR | Knee | Questionable |
| 2013 | 14 | Vance McDonald | TE | Ankle | Questionable |
| 2013 | 14 | Dan Skuta | LB | Foot | Questionable |
| 2013 | 14 | Joe Staley | T | Knee | Questionable |
| 2013 | 14 | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 14 | Garrett Celek | TE | Hamstring | Probable |
| 2013 | 14 | Frank Gore | RB | Ankle | Probable |
| 2013 | 14 | Ray McDonald | DT | Ankle | Probable |
| 2013 | 14 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 14 | Aldon Smith | LB | Shoulder | Probable |
| 2013 | 15 | Tarell Brown | CB | Ribs | Questionable |
| 2013 | 15 | Mike Iupati | G | Knee | Questionable |
| 2013 | 15 | Mario Manningham | WR | Knee | Questionable |
| 2013 | 15 | Vance McDonald | TE | Ankle | Questionable |
| 2013 | 15 | Jon Baldwin | WR | Shoulder | Probable |
| 2013 | 15 | Michael Crabtree | WR | Ankle | Probable |
| 2013 | 15 | Craig Dahl | S | Ankle | Probable |
| 2013 | 15 | Frank Gore | RB | Ankle | Probable |
| 2013 | 15 | Ray McDonald | DT | Ankle | Probable |
| 2013 | 15 | Dan Skuta | LB | Foot | Probable |
| 2013 | 15 | Aldon Smith | LB | Shoulder | Probable |
| 2013 | 15 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 15 | Adam Snyder | G | Not Injury Related | Probable |
| 2013 | 15 | Joe Staley | T | Knee | Probable |
| 2013 | 16 | Mario Manningham | WR | Illness / Knee | Questionable |
| 2013 | 16 | Mike Iupati | G | Knee | Questionable |
| 2013 | 16 | Vance McDonald | TE | Ankle | Questionable |
| 2013 | 16 | Dan Skuta | LB | Foot | Questionable |
| 2013 | 16 | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 16 | Tarell Brown | CB | Ribs | Probable |
| 2013 | 16 | Michael Crabtree | WR | Ankle / Wrist | Probable |
| 2013 | 16 | Jonathan Goodwin | C | Not Injury Related | Probable |
| 2013 | 16 | Frank Gore | RB | Ankle / Knee | Probable |
| 2013 | 16 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 17 | Mario Manningham | WR | Knee | Out |
| 2013 | 17 | Dan Skuta | LB | Foot | Questionable |
| 2013 | 17 | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 17 | Tarell Brown | CB | Ribs | Probable |
| 2013 | 17 | Michael Crabtree | WR | Wrist / Ankle | Probable |
| 2013 | 17 | Jonathan Goodwin | C | Not Injury Related | Probable |
| 2013 | 17 | Frank Gore | RB | Knee | Probable |
| 2013 | 17 | Mike Iupati | G | Knee | Probable |
| 2013 | 17 | Vance McDonald | TE | Ankle | Probable |
| 2013 | 17 | Kassim Osgood | WR | Shin | Probable |
| 2013 | 17 | Justin Smith | DT | Shoulder | Probable |
| 2013 | 18 (WC) | Carlos Rogers | CB | Hamstring | Questionable |
| 2013 | 18 (WC) | Dan Skuta | LB | Foot | Questionable |
| 2013 | 18 (WC) | Eric Wright | CB | Hamstring | Questionable |
| 2013 | 18 (WC) | Jon Baldwin | WR | Illness | Probable |
| 2013 | 18 (WC) | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 18 (WC) | Tarell Brown | CB | Ribs | Probable |
| 2013 | 18 (WC) | Jonathan Goodwin | C | Not Injury Related | Probable |
| 2013 | 18 (WC) | Frank Gore | RB | Knee | Probable |
| 2013 | 18 (WC) | Mike Iupati | G | Knee | Probable |
| 2013 | 18 (WC) | Justin Smith | DT | Shoulder | Probable |
| 2013 | 18 (WC) | Michael Crabtree | WR | Quadricep | Probable |
| 2013 | 19 (DIV) | Carlos Rogers | CB | Hamstring | Questionable |
| 2013 | 19 (DIV) | Dan Skuta | LB | Foot | Questionable |
| 2013 | 19 (DIV) | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 19 (DIV) | Michael Crabtree | WR | Wrist | Probable |
| 2013 | 19 (DIV) | Jonathan Goodwin | C | Not Injury Related | Probable |
| 2013 | 19 (DIV) | Frank Gore | RB | Knee | Probable |
| 2013 | 19 (DIV) | Justin Smith | DT | Shoulder | Probable |
| 2013 | 19 (DIV) | Demarcus Dobbs | DT | Knee / Shoulder | Probable |
| 2013 | 20 (CONF) | Carlos Rogers | CB | Hamstring | Questionable |
| 2013 | 20 (CONF) | Will Tukuafu | RB | Knee | Questionable |
| 2013 | 20 (CONF) | Navorro Bowman | LB | Wrist | Probable |
| 2013 | 20 (CONF) | Ahmad Brooks | LB | Illness | Probable |
| 2013 | 20 (CONF) | Michael Crabtree | WR | Wrist | Probable |
| 2013 | 20 (CONF) | Demarcus Dobbs | DE | Knee / Shoulder | Probable |
| 2013 | 20 (CONF) | Jonathan Goodwin | C | Foot | Probable |
| 2013 | 20 (CONF) | Frank Gore | RB | Knee | Probable |
| 2013 | 20 (CONF) | Dan Skuta | LB | Foot | Probable |
| 2013 | 20 (CONF) | Justin Smith | DT | Shoulder | Probable |
| 2014 | 1 | Anthony Davis | T | Hamstring | Out |
| 2014 | 1 | Marcus Martin | C | Knee | Out |
| 2014 | 1 | Michael Crabtree | WR | Calf | Questionable |
| 2014 | 1 | Chris Culliver | CB | Ankle | Probable |
| 2014 | 1 | Vance McDonald | TE | Hamstring | Probable |
| 2014 | 2 | Marcus Martin | C | Knee | Out |
| 2014 | 2 | Tramaine Brock | CB | Toe | Questionable |
| 2014 | 2 | Anthony Davis | T | Hamstring | Questionable |
| 2014 | 2 | Chris Culliver | CB | Concussion / Stinger | Questionable |
| 2014 | 2 | Andy Lee | P | right Knee | Probable |
| 2014 | 2 | Justin Smith | DT | Not Injury Related | Probable |
| 2014 | 3 | Marcus Martin | C | Knee | Out |
| 2014 | 3 | Tramaine Brock | CB | Toe | Questionable |
| 2014 | 3 | Anthony Davis | T | Hamstring | Questionable |
| 2014 | 3 | Vernon Davis | TE | Ankle / Knee | Questionable |
| 2014 | 3 | Vance McDonald | TE | Knee | Questionable |
| 2014 | 3 | Carlos Hyde | RB | Calf | Probable |
| 2014 | 3 | Colin Kaepernick | QB | Back | Probable |
| 2014 | 3 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 3 | Joe Staley | T | Knee | Probable |
| 2014 | 4 | Marcus Martin | C | Knee | Out |
| 2014 | 4 | Antoine Bethea | S | Ankle | Questionable |
| 2014 | 4 | Tramaine Brock | CB | Toe | Questionable |
| 2014 | 4 | Vernon Davis | TE | Ankle / Knee | Questionable |
| 2014 | 4 | Anthony Davis | T | Hamstring | Questionable |
| 2014 | 4 | Vance McDonald | TE | Knee | Questionable |
| 2014 | 4 | Michael Crabtree | WR | Quadricep | Probable |
| 2014 | 4 | Frank Gore | RB | Back | Probable |
| 2014 | 4 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 4 | Patrick Willis | LB | Wrist | Probable |
| 2014 | 5 | Marcus Martin | C | Knee | Doubtful |
| 2014 | 5 | Tramaine Brock | CB | Toe | Questionable |
| 2014 | 5 | Anthony Davis | T | Knee / Ankle | Questionable |
| 2014 | 5 | Vernon Davis | TE | Back | Questionable |
| 2014 | 5 | Ian Williams | DT | Ankle | Questionable |
| 2014 | 5 | Vance McDonald | TE | Knee | Questionable |
| 2014 | 5 | Eric Reid | S | Hamstring | Questionable |
| 2014 | 5 | Michael Crabtree | WR | Foot | Probable |
| 2014 | 5 | Frank Gore | RB | Back | Probable |
| 2014 | 5 | Andy Lee | P | right Ankle | Probable |
| 2014 | 5 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 5 | Antoine Bethea | S | Ankle | Probable |
| 2014 | 5 | Tony Jerod-Eddie | DE | Shoulder | Probable |
| 2014 | 6 | Tramaine Brock | CB | Toe | Out |
| 2014 | 6 | Anthony Davis | T | Knee / Ankle | Questionable |
| 2014 | 6 | Vernon Davis | TE | Back | Questionable |
| 2014 | 6 | Marcus Martin | C | Knee | Questionable |
| 2014 | 6 | Nick Moody | LB | Hamstring | Questionable |
| 2014 | 6 | Chris Cook | CB | Quadricep | Probable |
| 2014 | 6 | Tony Jerod-Eddie | DE | Shoulder | Probable |
| 2014 | 6 | Andy Lee | P | right Ankle | Probable |
| 2014 | 6 | Ray McDonald | DE | Knee | Probable |
| 2014 | 6 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 6 | Ian Williams | DT | Ankle | Probable |
| 2014 | 7 | Mike Iupati | G | Concussion | Out |
| 2014 | 7 | Patrick Willis | LB | Toe | Out |
| 2014 | 7 | Chris Culliver | CB | Shoulder / Hamstring | Questionable |
| 2014 | 7 | Jimmie Ward | S | Quadricep | Questionable |
| 2014 | 7 | Tramaine Brock | CB | Toe | Questionable |
| 2014 | 7 | Anthony Davis | T | Knee / Ankle | Questionable |
| 2014 | 7 | Chris Cook | CB | Quadricep | Probable |
| 2014 | 7 | Perrish Cox | CB | Quadricep | Probable |
| 2014 | 7 | Vernon Davis | TE | Back | Probable |
| 2014 | 7 | Tony Jerod-Eddie | DE | Shoulder | Probable |
| 2014 | 7 | Steve Johnson | WR | Hip | Probable |
| 2014 | 7 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 7 | Ian Williams | DT | Ankle / Shoulder | Probable |
| 2014 | 9 | Tramaine Brock | CB | Toe | Questionable |
| 2014 | 9 | Patrick Willis | LB | Toe | Questionable |
| 2014 | 9 | Chris Culliver | CB | Hamstring | Probable |
| 2014 | 9 | Jimmie Ward | S | Quadricep | Probable |
| 2014 | 10 | Dan Skuta | LB | Ankle | Questionable |
| 2014 | 10 | Patrick Willis | LB | Toe | Questionable |
| 2014 | 10 | Tramaine Brock | CB | Toe | Questionable |
| 2014 | 10 | Quinton Dial | DT | Eye | Questionable |
| 2014 | 10 | Brandon Lloyd | WR | Hamstring | Questionable |
| 2014 | 10 | Frank Gore | RB | Hip | Probable |
| 2014 | 10 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 10 | Ian Williams | DT | Shin | Probable |
| 2014 | 11 | Jimmie Ward | S | Foot | Out |
| 2014 | 11 | Ian Williams | DT | Fibula | Out |
| 2014 | 11 | Tramaine Brock | CB | Hamstring | Questionable |
| 2014 | 11 | Bruce Ellington | WR | Ankle | Questionable |
| 2014 | 11 | Dan Skuta | LB | Ankle | Questionable |
| 2014 | 11 | Chris Borland | LB | Shoulder | Probable |
| 2014 | 11 | Frank Gore | RB | Hip | Probable |
| 2014 | 11 | Ray McDonald | DE | Knee | Probable |
| 2014 | 11 | Eric Reid | S | Ankle | Probable |
| 2014 | 11 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 12 | Anthony Davis | T | Concussion | Out |
| 2014 | 12 | Glenn Dorsey | DT | Forearm | Out |
| 2014 | 12 | Tramaine Brock | CB | Hamstring | Questionable |
| 2014 | 12 | Bruce Ellington | WR | Ankle | Questionable |
| 2014 | 12 | Vance McDonald | TE | Hip | Questionable |
| 2014 | 12 | Dan Skuta | LB | Ankle | Questionable |
| 2014 | 12 | Chris Borland | LB | Shoulder | Probable |
| 2014 | 12 | Brandon Lloyd | WR | Quadricep | Probable |
| 2014 | 12 | Justin Smith | DE | Not Injury Related | Probable |
| 2014 | 13 | Derek Carrier | TE | Foot | Out |
| 2014 | 13 | Anthony Davis | T | Concussion | Out |
| 2014 | 13 | Glenn Dorsey | DT | Forearm | Out |
| 2014 | 13 | Tramaine Brock | CB | Hamstring | Questionable |
| 2014 | 13 | Bruce Ellington | WR | Ankle | Questionable |
| 2014 | 13 | Vance McDonald | TE | Back | Questionable |
| 2014 | 13 | Frank Gore | RB | Knee | Probable |
| 2014 | 13 | Brandon Lloyd | WR | Quadricep | Probable |
| 2014 | 13 | Bruce Miller | RB | Shoulder | Probable |
| 2014 | 13 | Eric Reid | S | Ankle | Probable |
| 2014 | 13 | Raymond Ventrone | S | Groin | Probable |
| 2014 | 13 | Ray McDonald | DE | Knee | Probable |
| 2014 | 13 | Justin Smith | DE | Back | Probable |
| 2014 | 14 | Anthony Davis | T | Concussion | Out |
| 2014 | 14 | Vance McDonald | TE | Back | Out |
| 2014 | 14 | Glenn Dorsey | DT | Forearm | Out |
| 2014 | 14 | Tramaine Brock | CB | Hamstring | Questionable |
| 2014 | 14 | Raymond Ventrone | S | Groin | Questionable |
| 2014 | 14 | Michael Crabtree | WR | Knee | Probable |
| 2014 | 14 | Bruce Ellington | WR | Ankle | Probable |
| 2014 | 14 | Steve Johnson | WR | Knee | Probable |
| 2014 | 14 | Brandon Lloyd | WR | Quadricep | Probable |
| 2014 | 14 | Justin Smith | DE | Back | Probable |
| 2014 | 14 | Joe Staley | T | Illness | Probable |
| 2014 | 14 | Chris Culliver | CB | Shoulder | Probable |
| 2014 | 14 | Carlos Hyde | RB | Shoulder | Probable |
| 2014 | 14 | Ray McDonald | DE | Finger | Probable |
| 2014 | 15 | Navorro Bowman | LB | Knee | Out |
| 2014 | 15 | Glenn Dorsey | DT | Forearm | Out |
| 2014 | 15 | Steve Johnson | WR | Knee | Out |
| 2014 | 15 | Anthony Davis | T | Concussion | Out |
| 2014 | 15 | Tramaine Brock | CB | Hamstring | Questionable |
| 2014 | 15 | Chris Culliver | CB | Knee | Questionable |
| 2014 | 15 | Marcus Martin | C | Knee | Questionable |
| 2014 | 15 | Raymond Ventrone | S | Groin | Questionable |
| 2014 | 15 | Mike Iupati | G | Elbow | Probable |
| 2014 | 15 | Ray McDonald | DE | Finger | Probable |
| 2014 | 15 | Justin Smith | DE | Back | Probable |
| 2014 | 16 | Chris Borland | LB | Ankle | Out |
| 2014 | 16 | Tramaine Brock | CB | Hamstring | Out |
| 2014 | 16 | Carlos Hyde | RB | Ankle | Out |
| 2014 | 16 | Steve Johnson | WR | Knee | Out |
| 2014 | 16 | Ahmad Brooks | LB | Thumb | Questionable |
| 2014 | 16 | Michael Crabtree | WR | Knee | Questionable |
| 2014 | 16 | Anthony Davis | T | Concussion | Questionable |
| 2014 | 16 | Frank Gore | RB | Concussion | Questionable |
| 2014 | 16 | Raymond Ventrone | S | Groin | Questionable |
| 2014 | 16 | Michael Wilhoite | LB | Hip | Questionable |
| 2014 | 16 | Perrish Cox | CB | Ankle | Probable |
| 2014 | 16 | Chris Culliver | CB | Knee | Probable |
| 2014 | 16 | Quinton Dial | DT | Knee | Probable |
| 2014 | 16 | Tony Jerod-Eddie | DE | Foot | Probable |
| 2014 | 16 | Jonathan Martin | T | Illness | Probable |
| 2014 | 16 | Marcus Martin | C | Knee | Probable |
| 2014 | 16 | Kyle Nelson | LS | Back | Probable |
| 2014 | 16 | Justin Smith | DE | Back | Probable |
| 2014 | 17 | Alex Boone | G | Knee | — |
| 2014 | 17 | Raymond Ventrone | S | Groin | — |
| 2014 | 17 | Carlos Hyde | RB | Ankle | Out |
| 2014 | 17 | Steve Johnson | WR | Knee | Out |
| 2014 | 17 | Eric Reid | S | Concussion | Out |
| 2014 | 17 | Perrish Cox | CB | Shoulder | Questionable |
| 2014 | 17 | Tramaine Brock | CB | Hamstring | Questionable |
| 2014 | 17 | Ahmad Brooks | LB | Thumb | Questionable |
| 2014 | 17 | Bruce Ellington | WR | Hamstring | Questionable |
| 2014 | 17 | Michael Crabtree | WR | Knee | Probable |
| 2014 | 17 | Chris Culliver | CB | Knee | Probable |
| 2014 | 17 | Brandon Lloyd | WR | Groin | Probable |
| 2014 | 17 | Marcus Martin | C | Illness | Probable |
| 2014 | 17 | Justin Smith | DE | Back | Probable |
| 2015 | 1 | Tramaine Brock | CB | Hamstring | Probable |
| 2015 | 2 | Reggie Bush | RB | Calf | Out |
| 2015 | 2 | Bruce Ellington | WR | Ankle | Questionable |
| 2015 | 3 | Reggie Bush | RB | Calf | Doubtful |
| 2015 | 3 | Bruce Ellington | WR | Ankle | Questionable |
| 2015 | 3 | Vance McDonald | TE | Knee | Questionable |
| 2015 | 3 | Blake Bell | TE | Back | Probable |
| 2015 | 3 | Alex Boone | G | Shoulder | Probable |
| 2015 | 3 | Navorro Bowman | LB | Not Injury Related | Probable |
| 2015 | 3 | Carlos Hyde | RB | Quadricep | Probable |
| 2015 | 3 | Torrey Smith | WR | Knee | Probable |
| 2015 | 4 | Vernon Davis | TE | Knee | Doubtful |
| 2015 | 4 | Kenneth Acker | CB | Back | Probable |
| 2015 | 4 | Alex Boone | G | Shoulder | Probable |
| 2015 | 4 | Navorro Bowman | LB | Not Injury Related | Probable |
| 2015 | 4 | Ahmad Brooks | LB | Shoulder | Probable |
| 2015 | 4 | Reggie Bush | RB | Calf | Probable |
| 2015 | 4 | Bruce Ellington | WR | Ankle | Probable |
| 2015 | 4 | L.J. McCray | S | Hip | Probable |
| 2015 | 4 | Vance McDonald | TE | Knee | Probable |
| 2015 | 4 | Eric Reid | S | Hip | Probable |
| 2015 | 5 | Vernon Davis | TE | Knee | Out |
| 2015 | 5 | Ahmad Brooks | LB | Not Injury Related / Shoulder | Doubtful |
| 2015 | 5 | Quinton Patton | WR | Concussion | Questionable |
| 2015 | 5 | Joe Staley | T | Knee | Questionable |
| 2015 | 5 | Navorro Bowman | LB | Not Injury Related | Probable |
| 2015 | 5 | L.J. McCray | S | Knee | Probable |
| 2015 | 5 | Vance McDonald | TE | Chest | Probable |
| 2015 | 5 | Alex Boone | G | Shoulder / Ankle | Probable |
| 2015 | 6 | Reggie Bush | RB | Calf | Doubtful |
| 2015 | 6 | Ahmad Brooks | LB | Not Injury Related / Shoulder | Questionable |
| 2015 | 6 | Vernon Davis | TE | Knee | Questionable |
| 2015 | 6 | Bruce Ellington | WR | Calf | Questionable |
| 2015 | 6 | Eli Harold | LB | Knee | Questionable |
| 2015 | 6 | Carlos Hyde | RB | Foot | Questionable |
| 2015 | 6 | Brandon Thomas | G | Ankle | Questionable |
| 2015 | 6 | Alex Boone | G | Shoulder | Probable |
| 2015 | 6 | Navorro Bowman | LB | Not Injury Related | Probable |
| 2015 | 6 | Vance McDonald | TE | Chest | Probable |
| 2015 | 6 | Joe Staley | T | Knee | Probable |
| 2015 | 7 | Anquan Boldin | WR | Hamstring | Questionable |
| 2015 | 7 | Carlos Hyde | RB | Foot | Questionable |
| 2015 | 7 | Erik Pears | T | Back | Questionable |
| 2015 | 7 | Alex Boone | G | Shoulder | Probable |
| 2015 | 7 | Navorro Bowman | LB | Shoulder | Probable |
| 2015 | 7 | Ahmad Brooks | LB | Shoulder | Probable |
| 2015 | 7 | Reggie Bush | RB | Calf | Probable |
| 2015 | 7 | Vernon Davis | TE | Knee | Probable |
| 2015 | 7 | Bruce Ellington | WR | Calf | Probable |
| 2015 | 7 | Vance McDonald | TE | Chest | Probable |
| 2015 | 7 | Eric Reid | S | Chest | Probable |
| 2015 | 7 | Joe Staley | T | Knee | Probable |
| 2015 | 7 | Brandon Thomas | G | Ankle | Probable |
| 2015 | 8 | Carlos Hyde | RB | Foot | Out |
| 2015 | 8 | Anquan Boldin | WR | Hamstring | Questionable |
| 2015 | 8 | Alex Boone | G | Shoulder / Knee | Probable |
| 2015 | 8 | Navorro Bowman | LB | Shoulder | Probable |
| 2015 | 8 | Ahmad Brooks | LB | Shoulder | Probable |
| 2015 | 8 | Tony Jerod-Eddie | DT | Not Injury Related | Probable |
| 2015 | 8 | Colin Kaepernick | QB | right Hand | Probable |
| 2015 | 8 | Erik Pears | T | Back | Probable |
| 2015 | 8 | Eric Reid | S | Chest | Probable |
| 2015 | 8 | Joe Staley | T | Shoulder | Probable |
| 2015 | 9 | Mike Davis | RB | Hand | Out |
| 2015 | 9 | Carlos Hyde | RB | Foot | Out |
| 2015 | 9 | L.J. McCray | S | Knee | Out |
| 2015 | 9 | Anquan Boldin | WR | Hamstring | Doubtful |
| 2015 | 9 | Kenneth Acker | CB | Chest / Concussion | Questionable |
| 2015 | 9 | Tramaine Brock | CB | Shin | Questionable |
| 2015 | 9 | Garrett Celek | TE | Concussion | Questionable |
| 2015 | 9 | Keith Reaser | CB | Not Injury Related / Ankle | Questionable |
| 2015 | 9 | Alex Boone | G | Knee | Probable |
| 2015 | 9 | Navorro Bowman | LB | Shoulder | Probable |
| 2015 | 9 | Ahmad Brooks | LB | Shoulder | Probable |
| 2015 | 9 | Bradley Pinion | P | right Calf | Probable |
| 2015 | 9 | Eric Reid | S | Chest | Probable |
| 2015 | 9 | Joe Staley | T | Shoulder | Probable |
| 2015 | 11 | Carlos Hyde | RB | Foot | Out |
| 2015 | 11 | Anquan Boldin | WR | Hamstring | Questionable |
| 2015 | 11 | Kenneth Acker | CB | Concussion / Chest | Probable |
| 2015 | 11 | Navorro Bowman | LB | Shoulder | Probable |
| 2015 | 11 | Tramaine Brock | CB | Shin | Probable |
| 2015 | 11 | Ahmad Brooks | LB | Shoulder | Probable |
| 2015 | 11 | Colin Kaepernick | QB | left Shoulder | Probable |
| 2015 | 11 | Keith Reaser | CB | Ankle | Probable |
| 2015 | 11 | Eric Reid | S | Chest | Probable |
| 2015 | 12 | Carlos Hyde | RB | Foot | Out |
| 2015 | 12 | Ahmad Brooks | LB | Concussion / Toe | Questionable |
| 2015 | 12 | Anquan Boldin | WR | Hamstring | Probable |
| 2015 | 12 | Alex Boone | G | Triceps | Probable |
| 2015 | 12 | Navorro Bowman | LB | Shoulder / Finger | Probable |
| 2015 | 12 | Tony Jerod-Eddie | DT | Hip | Probable |
| 2015 | 12 | Erik Pears | T | Knee | Probable |
| 2015 | 12 | Keith Reaser | CB | Ankle | Probable |
| 2015 | 12 | Arik Armstead | DT | Shoulder | Probable |
| 2015 | 12 | Jaquiski Tartt | S | Knee | Probable |
| 2015 | 13 | Garrett Celek | TE | Ankle | Out |
| 2015 | 13 | Carlos Hyde | RB | Foot | Out |
| 2015 | 13 | Arik Armstead | DT | Shoulder | Probable |
| 2015 | 13 | Blake Bell | TE | Finger | Probable |
| 2015 | 13 | Anquan Boldin | WR | Hamstring | Probable |
| 2015 | 13 | Alex Boone | G | Triceps | Probable |
| 2015 | 13 | Navorro Bowman | LB | Shoulder / Finger | Probable |
| 2015 | 13 | Ahmad Brooks | LB | Toe | Probable |
| 2015 | 13 | Quinton Dial | DT | Shoulder | Probable |
| 2015 | 13 | Bruce Ellington | WR | Wrist | Probable |
| 2015 | 13 | Tony Jerod-Eddie | DT | Hip | Probable |
| 2015 | 13 | Dontae Johnson | CB | Hamstring | Probable |
| 2015 | 13 | Erik Pears | T | Knee | Probable |
| 2015 | 13 | Keith Reaser | CB | Ankle | Probable |
| 2015 | 13 | Torrey Smith | WR | Back | Probable |
| 2015 | 13 | Jaquiski Tartt | S | Knee | Probable |
| 2015 | 13 | Michael Wilhoite | LB | Ankle | Probable |
| 2015 | 14 | Carlos Hyde | RB | Foot | Out |
| 2015 | 14 | Vance McDonald | TE | Concussion | Out |
| 2015 | 14 | Michael Wilhoite | LB | Ankle | Out |
| 2015 | 14 | Tramaine Brock | CB | Foot | Questionable |
| 2015 | 14 | Aaron Lynch | LB | Concussion | Questionable |
| 2015 | 14 | Torrey Smith | WR | Back / Toe | Questionable |
| 2015 | 14 | Arik Armstead | DT | Shoulder | Probable |
| 2015 | 14 | Anquan Boldin | WR | Hamstring | Probable |
| 2015 | 14 | Alex Boone | G | Knee | Probable |
| 2015 | 14 | Navorro Bowman | LB | Shoulder / Finger | Probable |
| 2015 | 14 | Quinton Dial | DT | Shoulder | Probable |
| 2015 | 14 | Kendall Gaskins | RB | Hamstring | Probable |
| 2015 | 14 | Marcus Martin | C | Ankle | Probable |
| 2015 | 14 | Erik Pears | T | Knee | Probable |
| 2015 | 14 | Mike Purcell | DT | Shoulder | Probable |
| 2015 | 14 | Joe Staley | T | Knee | Probable |
| 2015 | 14 | Jaquiski Tartt | S | Ankle | Probable |
| 2015 | 14 | Andrew Tiller | G | Knee | Probable |
| 2015 | 14 | Eli Harold | LB | Shoulder | Probable |
| 2015 | 15 | Alex Boone | G | Knee | Out |
| 2015 | 15 | Michael Wilhoite | LB | Ankle | Out |
| 2015 | 15 | Tramaine Brock | CB | Hamstring | Questionable |
| 2015 | 15 | Aaron Lynch | LB | Concussion | Questionable |
| 2015 | 15 | Torrey Smith | WR | Back / Toe | Questionable |
| 2015 | 15 | Arik Armstead | DT | Shoulder | Probable |
| 2015 | 15 | Anquan Boldin | WR | Hamstring | Probable |
| 2015 | 15 | Navorro Bowman | LB | Shoulder / Finger | Probable |
| 2015 | 15 | Ahmad Brooks | LB | Shoulder | Probable |
| 2015 | 15 | Marcus Cromartie | CB | Hip | Probable |
| 2015 | 15 | Quinton Dial | DT | Shoulder | Probable |
| 2015 | 15 | Kendall Gaskins | RB | Concussion | Probable |
| 2015 | 15 | Eli Harold | LB | Shoulder / Hamstring | Probable |
| 2015 | 15 | Marcus Martin | C | Ankle | Probable |
| 2015 | 15 | Vance McDonald | TE | Concussion | Probable |
| 2015 | 15 | Erik Pears | T | Knee | Probable |
| 2015 | 15 | Mike Purcell | DT | Shoulder | Probable |
| 2015 | 15 | Eric Reid | S | Shoulder | Probable |
| 2015 | 15 | Jerome Simpson | WR | Finger | Probable |
| 2015 | 15 | Joe Staley | T | Knee | Probable |
| 2015 | 15 | Jaquiski Tartt | S | Ankle | Probable |
| 2015 | 15 | Andrew Tiller | G | Knee | Probable |
| 2015 | 15 | Jimmie Ward | S | Elbow | Probable |
| 2015 | 16 | Alex Boone | G | Knee | Out |
| 2015 | 16 | Shaun Draughn | RB | Knee | Out |
| 2015 | 16 | Marcus Martin | C | Concussion | Out |
| 2015 | 16 | Michael Wilhoite | LB | Ankle | Out |
| 2015 | 16 | Arik Armstead | DT | Shoulder | Probable |
| 2015 | 16 | Navorro Bowman | LB | Shoulder / Finger | Probable |
| 2015 | 16 | Tramaine Brock | CB | Hamstring | Probable |
| 2015 | 16 | Ahmad Brooks | LB | Shoulder / Back | Probable |
| 2015 | 16 | Quinton Dial | DT | Shoulder | Probable |
| 2015 | 16 | Eli Harold | LB | Shoulder / Hamstring | Probable |
| 2015 | 16 | Dontae Johnson | CB | Ankle | Probable |
| 2015 | 16 | Aaron Lynch | LB | Concussion | Probable |
| 2015 | 16 | Erik Pears | T | Knee | Probable |
| 2015 | 16 | Torrey Smith | WR | Back / Foot | Probable |
| 2015 | 16 | Joe Staley | T | Knee | Probable |
| 2015 | 16 | Jaquiski Tartt | S | Knee | Probable |
| 2015 | 17 | Quinton Dial | DT | Back | Out |
| 2015 | 17 | Michael Wilhoite | LB | Ankle | Out |
| 2015 | 17 | Marcus Martin | C | Concussion | Doubtful |
| 2015 | 17 | Jaquiski Tartt | S | Knee | Doubtful |
| 2015 | 17 | Navorro Bowman | LB | Shoulder / Finger | Probable |
| 2015 | 17 | Tramaine Brock | CB | Hamstring | Probable |
| 2015 | 17 | Ahmad Brooks | LB | Shoulder / Back | Probable |
| 2015 | 17 | Trenton Brown | T | Knee | Probable |
| 2015 | 17 | Eli Harold | LB | Finger | Probable |
| 2015 | 17 | Dontae Johnson | CB | Ankle | Probable |
| 2015 | 17 | Erik Pears | T | Knee | Probable |
| 2015 | 17 | Eric Reid | S | Hip | Probable |
| 2015 | 17 | Joe Staley | T | Knee / Illness | Probable |
| 2015 | 17 | Arik Armstead | DT | Shoulder / Shin | Probable |
| 2015 | 17 | Bruce Miller | RB | Foot | Probable |
| 2015 | 17 | Torrey Smith | WR | Back / Foot | Probable |
| 2016 | 1 | Chris Davis | CB | Hamstring | Doubtful |
| 2016 | 1 | Anthony Davis | T | Not Injury Related | Questionable |
| 2016 | 1 | Arik Armstead | DT | Shoulder | Questionable |
| 2016 | 1 | Nick Bellore | LB | Knee | Questionable |
| 2016 | 1 | Quinton Dial | DT | Knee | Questionable |
| 2016 | 1 | Glenn Dorsey | DT | Knee | Questionable |
| 2016 | 1 | Keith Reaser | CB | Ankle | Questionable |
| 2016 | 2 | Arik Armstead | DT | Shoulder / Knee | — |
| 2016 | 2 | Nick Bellore | LB | Knee | — |
| 2016 | 2 | Quinton Dial | DT | Knee | — |
| 2016 | 2 | Glenn Dorsey | DT | Knee | — |
| 2016 | 2 | Anthony Davis | T | Concussion | Out |
| 2016 | 2 | Marcus Cromartie | S | Ankle | Questionable |
| 2016 | 2 | Chris Davis | CB | Hamstring | Questionable |
| 2016 | 2 | Keith Reaser | CB | Ankle | Questionable |
| 2016 | 2 | Andrew Tiller | G | Ankle | Questionable |
| 2016 | 3 | Arik Armstead | DT | Shoulder | — |
| 2016 | 3 | Nick Bellore | LB | Knee | — |
| 2016 | 3 | Quinton Dial | DT | Knee | — |
| 2016 | 3 | Glenn Dorsey | DT | Knee | — |
| 2016 | 3 | Mike Purcell | DT | Ankle | — |
| 2016 | 3 | Keith Reaser | CB | Ankle | — |
| 2016 | 3 | Andrew Tiller | G | Ankle | — |
| 2016 | 3 | Anthony Davis | T | Concussion | Out |
| 2016 | 3 | Marcus Cromartie | S | Ankle | Questionable |
| 2016 | 3 | Jaquiski Tartt | S | Knee | Questionable |
| 2016 | 4 | Arik Armstead | DT | Shoulder | — |
| 2016 | 4 | Marcus Cromartie | S | Ankle | — |
| 2016 | 4 | Chris Davis | CB | Quadricep | — |
| 2016 | 4 | Quinton Dial | DT | Knee | — |
| 2016 | 4 | Glenn Dorsey | DT | Knee | — |
| 2016 | 4 | Mike Purcell | DT | Ankle | — |
| 2016 | 4 | Keith Reaser | CB | Ankle | — |
| 2016 | 4 | Torrey Smith | WR | Foot | — |
| 2016 | 4 | Jaquiski Tartt | S | Knee | — |
| 2016 | 4 | Andrew Tiller | G | Ankle | — |
| 2016 | 4 | Jimmie Ward | CB | Quadricep | Out |
| 2016 | 4 | Garrett Celek | TE | Back | Questionable |
| 2016 | 4 | Vance McDonald | TE | Hip | Questionable |
| 2016 | 5 | Arik Armstead | DT | Shoulder | — |
| 2016 | 5 | Zane Beadles | G | Ankle | — |
| 2016 | 5 | Marcus Cromartie | S | Ankle | — |
| 2016 | 5 | Chris Davis | CB | Quadricep | — |
| 2016 | 5 | Quinton Dial | DT | Knee | — |
| 2016 | 5 | Mike Purcell | DT | Ankle | — |
| 2016 | 5 | Keith Reaser | CB | Ankle | — |
| 2016 | 5 | Jaquiski Tartt | S | Knee | — |
| 2016 | 5 | Andrew Tiller | G | Ankle | — |
| 2016 | 5 | Navorro Bowman | LB | Achilles | Out |
| 2016 | 5 | DeForest Buckner | DT | Foot | Out |
| 2016 | 5 | Jimmie Ward | CB | Quadricep | Out |
| 2016 | 5 | Glenn Dorsey | DT | Knee | Questionable |
| 2016 | 5 | Jeremy Kerley | WR | Ankle | Questionable |
| 2016 | 5 | Vance McDonald | TE | Hip | Questionable |
| 2016 | 6 | Arik Armstead | DT | Shoulder | — |
| 2016 | 6 | Zane Beadles | G | Ankle | — |
| 2016 | 6 | Cornellius Carradine | LB | Toe | — |
| 2016 | 6 | Quinton Dial | DT | Knee | — |
| 2016 | 6 | Jeremy Kerley | WR | Ankle | — |
| 2016 | 6 | Vance McDonald | TE | Hip | — |
| 2016 | 6 | Jimmie Ward | CB | Quadricep | Out |
| 2016 | 6 | Ahmad Brooks | LB | Groin | Questionable |
| 2016 | 6 | DeForest Buckner | DT | Foot | Questionable |
| 2016 | 6 | Glenn Dorsey | DT | Knee | Questionable |
| 2016 | 6 | Jaquiski Tartt | S | Quadricep | Questionable |
| 2016 | 7 | Phil Dawson | K | Illness | — |
| 2016 | 7 | Arik Armstead | DT | Shoulder | — |
| 2016 | 7 | Zane Beadles | G | Ankle | — |
| 2016 | 7 | DeForest Buckner | DT | Foot | — |
| 2016 | 7 | Quinton Dial | DT | Knee | — |
| 2016 | 7 | Blaine Gabbert | QB | Back | — |
| 2016 | 7 | Joshua Garnett | G | Foot | — |
| 2016 | 7 | Jeremy Kerley | WR | Ankle | — |
| 2016 | 7 | Vance McDonald | TE | Hip | — |
| 2016 | 7 | Jaquiski Tartt | S | Quadricep | — |
| 2016 | 7 | Jimmie Ward | CB | Quadricep | — |
| 2016 | 7 | Carlos Hyde | RB | Shoulder | Out |
| 2016 | 7 | Glenn Dorsey | DT | Knee | Questionable |
| 2016 | 7 | Rashard Robinson | CB | Concussion | Questionable |
| 2016 | 7 | Torrey Smith | WR | Back | Questionable |
| 2016 | 9 | Arik Armstead | DT | Shoulder | — |
| 2016 | 9 | Zane Beadles | G | Ankle / Knee | — |
| 2016 | 9 | Nick Bellore | LB | Shoulder | — |
| 2016 | 9 | Ronald Blair | DT | Ankle | — |
| 2016 | 9 | Quinton Dial | DT | Knee | — |
| 2016 | 9 | Glenn Dorsey | DT | Knee | — |
| 2016 | 9 | Aaron Lynch | LB | Ankle | Out |
| 2016 | 9 | Rashard Robinson | CB | Knee | Out |
| 2016 | 9 | Carlos Hyde | RB | Shoulder | Questionable |
| 2016 | 10 | Zane Beadles | G | Ankle / Knee | — |
| 2016 | 10 | Nick Bellore | LB | Shoulder | — |
| 2016 | 10 | Quinton Dial | DT | Knee / Neck | — |
| 2016 | 10 | Glenn Dorsey | DT | Knee | — |
| 2016 | 10 | Daniel Kilgore | C | Hamstring | — |
| 2016 | 10 | Eric Reid | S | Knee | — |
| 2016 | 10 | Aaron Lynch | LB | Ankle | Out |
| 2016 | 10 | Carlos Hyde | RB | Shoulder | Questionable |
| 2016 | 10 | Rashard Robinson | CB | Knee | Questionable |
| 2016 | 10 | Torrey Smith | WR | Back | Questionable |
| 2016 | 11 | Zane Beadles | G | Ankle / Knee | — |
| 2016 | 11 | Tramaine Brock | CB | Hamstring | — |
| 2016 | 11 | Quinton Dial | DT | Knee / Neck | — |
| 2016 | 11 | Glenn Dorsey | DT | Knee | — |
| 2016 | 11 | Eli Harold | LB | Toe | — |
| 2016 | 11 | Carlos Hyde | RB | Shoulder | — |
| 2016 | 11 | Daniel Kilgore | C | Hamstring / Calf | — |
| 2016 | 11 | Eric Reid | S | Knee | — |
| 2016 | 11 | Aaron Lynch | LB | Ankle | Out |
| 2016 | 11 | Rashard Robinson | CB | Knee | Questionable |
| 2016 | 11 | Torrey Smith | WR | Shoulder | Questionable |
| 2016 | 12 | Zane Beadles | G | Ankle / Knee | — |
| 2016 | 12 | Glenn Dorsey | DT | Knee | — |
| 2016 | 12 | Eli Harold | LB | Toe | — |
| 2016 | 12 | Daniel Kilgore | C | Hamstring / Calf | — |
| 2016 | 12 | Keith Reaser | CB | Ankle / Shoulder | — |
| 2016 | 12 | Rashard Robinson | CB | Knee | — |
| 2016 | 12 | Jaquiski Tartt | S | Calf | — |
| 2016 | 12 | Quinton Dial | DT | Knee / Neck | Questionable |
| 2016 | 12 | Aaron Lynch | LB | Ankle | Questionable |
| 2016 | 12 | Torrey Smith | WR | Shoulder | Questionable |
| 2016 | 12 | Jimmie Ward | CB | Concussion | Questionable |
| 2016 | 13 | Zane Beadles | G | Ankle / Knee | — |
| 2016 | 13 | Ronald Blair | DT | Hamstring | — |
| 2016 | 13 | Quinton Dial | DT | Knee / Neck | — |
| 2016 | 13 | Glenn Dorsey | DT | Knee | — |
| 2016 | 13 | Eli Harold | LB | Toe | — |
| 2016 | 13 | Daniel Kilgore | C | Hamstring / Calf | — |
| 2016 | 13 | Rashard Robinson | CB | Knee | — |
| 2016 | 13 | Torrey Smith | WR | Shoulder | — |
| 2016 | 13 | Aaron Lynch | LB | Ankle | Questionable |
| 2016 | 13 | Quinton Patton | WR | Concussion | Questionable |
| 2016 | 14 | Ronald Blair | DT | Hamstring | — |
| 2016 | 14 | Glenn Dorsey | DT | Knee | — |
| 2016 | 14 | Shaun Draughn | RB | Ribs | — |
| 2016 | 14 | Eli Harold | LB | Toe | — |
| 2016 | 14 | Daniel Kilgore | C | Hamstring | — |
| 2016 | 14 | Joe Staley | T | Hamstring | Doubtful |
| 2016 | 14 | Quinton Dial | DT | Elbow | Questionable |
| 2016 | 14 | Aaron Lynch | LB | Ankle | Questionable |
| 2016 | 15 | Aaron Burbridge | WR | Hamstring | — |
| 2016 | 15 | Quinton Dial | DT | Elbow | — |
| 2016 | 15 | Glenn Dorsey | DT | Knee | — |
| 2016 | 15 | Shaun Draughn | RB | Ribs | — |
| 2016 | 15 | Eli Harold | LB | Toe | — |
| 2016 | 15 | Colin Kaepernick | QB | Neck | — |
| 2016 | 15 | Aaron Lynch | LB | Ankle | — |
| 2016 | 15 | Torrey Smith | WR | Concussion | Out |
| 2016 | 15 | Joe Staley | T | Hamstring | Doubtful |
| 2016 | 16 | Torrey Smith | WR | Concussion | — |
| 2016 | 16 | DeForest Buckner | DT | Hip | — |
| 2016 | 16 | Aaron Burbridge | WR | Hamstring | — |
| 2016 | 16 | Quinton Dial | DT | Elbow | — |
| 2016 | 16 | Shaun Draughn | RB | Ribs | — |
| 2016 | 16 | Eli Harold | LB | Toe | — |
| 2016 | 16 | Joe Staley | T | Hamstring | Doubtful |
| 2016 | 16 | Dontae Johnson | CB | Groin | Doubtful |
| 2016 | 16 | Glenn Dorsey | DT | Knee / Ribs | Questionable |
| 2016 | 16 | Marcus Martin | C | Ankle | Questionable |
| 2016 | 17 | Quinton Dial | DT | Elbow | — |
| 2016 | 17 | Glenn Dorsey | DT | Knee / Ribs | — |
| 2016 | 17 | Shaun Draughn | RB | Ribs | — |
| 2016 | 17 | Eli Harold | LB | Toe | — |
| 2016 | 17 | Marcus Martin | C | Ankle | Out |
| 2016 | 17 | Andrew Tiller | G | Ankle | Out |
| 2016 | 17 | Dontae Johnson | CB | Groin | Questionable |
| 2016 | 17 | Rashard Robinson | CB | Hamstring | Questionable |
| 2016 | 17 | Joe Staley | T | Hamstring | Questionable |
| 2017 | 1 | Jimmie Ward | S | Hamstring | Doubtful |
| 2017 | 1 | George Kittle | TE | Hamstring | Questionable |
| 2017 | 1 | Aaron Lynch | DE | Back | Questionable |
| 2017 | 2 | George Kittle | TE | Hamstring / Calf | — |
| 2017 | 2 | Joe Staley | T | Not Injury Related | — |
| 2017 | 2 | Reuben Foster | LB | Ankle | Out |
| 2017 | 2 | Jimmie Ward | S | Hamstring | Questionable |
| 2017 | 3 | Reuben Foster | LB | Ankle | Out |
| 2017 | 3 | Eric Reid | S | Knee | Out |
| 2017 | 3 | Eli Harold | LB | Foot | Questionable |
| 2017 | 3 | George Kittle | TE | Hip | Questionable |
| 2017 | 3 | Jaquiski Tartt | S | Neck | Questionable |
| 2017 | 3 | Jimmie Ward | S | Hamstring | Questionable |
| 2017 | 4 | Joe Staley | T | Not Injury Related | — |
| 2017 | 4 | Reuben Foster | LB | Ankle | Out |
| 2017 | 4 | Eric Reid | S | Knee | Out |
| 2017 | 4 | Brock Coyle | LB | Concussion | Questionable |
| 2017 | 4 | Carlos Hyde | RB | Hip | Questionable |
| 2017 | 4 | Kyle Juszczyk | RB | Concussion | Questionable |
| 2017 | 4 | Jaquiski Tartt | S | Concussion | Questionable |
| 2017 | 4 | Pita Taumoepenu | DE | Ankle | Questionable |
| 2017 | 5 | Navorro Bowman | LB | Not Injury Related | — |
| 2017 | 5 | Matt Breida | RB | Ankle | — |
| 2017 | 5 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 5 | Carlos Hyde | RB | Hip | — |
| 2017 | 5 | Joe Staley | T | Not Injury Related | — |
| 2017 | 5 | Pita Taumoepenu | DE | Ankle | — |
| 2017 | 5 | Adrian Colbert | S | Hamstring | Out |
| 2017 | 5 | Reuben Foster | LB | Ankle | Out |
| 2017 | 5 | Eric Reid | S | Knee | Out |
| 2017 | 5 | Dekoda Watson | LB | Groin | Out |
| 2017 | 5 | Marquise Goodwin | WR | Concussion | Questionable |
| 2017 | 6 | Ray-Ray Armstrong | LB | Shoulder | — |
| 2017 | 6 | Navorro Bowman | LB | Not Injury Related | — |
| 2017 | 6 | Pierre Garcon | WR | Not Injury Related | — |
| 2017 | 6 | D.J. Jones | DT | Back | — |
| 2017 | 6 | George Kittle | TE | Chest | — |
| 2017 | 6 | Earl Mitchell | DT | Knee | — |
| 2017 | 6 | Joe Staley | T | Not Injury Related | — |
| 2017 | 6 | Jimmie Ward | S | Shoulder | — |
| 2017 | 6 | Kyle Juszczyk | RB | Back | Out |
| 2017 | 6 | Adrian Colbert | S | Hamstring | Questionable |
| 2017 | 6 | Reuben Foster | LB | Ankle | Questionable |
| 2017 | 6 | Eric Reid | S | Knee | Questionable |
| 2017 | 6 | Dekoda Watson | LB | Groin | Questionable |
| 2017 | 6 | Ahkello Witherspoon | CB | Concussion | Questionable |
| 2017 | 7 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 7 | Pierre Garcon | WR | Not Injury Related | — |
| 2017 | 7 | D.J. Jones | DT | Quadricep | — |
| 2017 | 7 | George Kittle | TE | Back / Elbow | — |
| 2017 | 7 | Earl Mitchell | DT | Thumb | — |
| 2017 | 7 | Eric Reid | S | Knee | — |
| 2017 | 7 | Joe Staley | T | Not Injury Related | — |
| 2017 | 7 | Ahkello Witherspoon | CB | Chest | — |
| 2017 | 7 | Kyle Juszczyk | RB | Back | Out |
| 2017 | 7 | Aaron Lynch | DE | Calf | Out |
| 2017 | 7 | Ray-Ray Armstrong | LB | Shoulder | Questionable |
| 2017 | 7 | Brock Coyle | LB | Shoulder | Questionable |
| 2017 | 7 | Reuben Foster | LB | Ankle | Questionable |
| 2017 | 7 | Dekoda Watson | LB | Groin | Questionable |
| 2017 | 8 | Ray-Ray Armstrong | LB | Shoulder | — |
| 2017 | 8 | Brock Coyle | LB | Shoulder | — |
| 2017 | 8 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 8 | Pierre Garcon | WR | Not Injury Related | — |
| 2017 | 8 | Kyle Juszczyk | RB | Back | — |
| 2017 | 8 | Earl Mitchell | DT | Thumb | — |
| 2017 | 8 | Eric Reid | S | Knee | — |
| 2017 | 8 | Joe Staley | T | Knee | — |
| 2017 | 8 | Aaron Lynch | DE | Calf | Out |
| 2017 | 8 | K'Waun Williams | CB | Quadricep | Out |
| 2017 | 8 | Trenton Brown | T | Concussion | Questionable |
| 2017 | 8 | Reuben Foster | LB | Ankle / Ribs | Questionable |
| 2017 | 8 | Brandon Fusco | G | Biceps | Questionable |
| 2017 | 8 | Marquise Goodwin | WR | Back | Questionable |
| 2017 | 9 | Matt Breida | RB | Knee | — |
| 2017 | 9 | Trenton Brown | T | Concussion | — |
| 2017 | 9 | Brock Coyle | LB | Shoulder | — |
| 2017 | 9 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 9 | Brandon Fusco | G | Biceps | — |
| 2017 | 9 | Eric Reid | S | Knee | — |
| 2017 | 9 | Pierre Garcon | WR | Neck | Out |
| 2017 | 9 | Garry Gilliam | T | Knee | Out |
| 2017 | 9 | D.J. Jones | DT | Knee | Out |
| 2017 | 9 | Aaron Lynch | DE | Calf | Out |
| 2017 | 9 | Joe Staley | T | Eye | Out |
| 2017 | 9 | Solomon Thomas | DE | Knee | Out |
| 2017 | 9 | K'Waun Williams | CB | Quadricep | Out |
| 2017 | 9 | Reuben Foster | LB | Ribs | Questionable |
| 2017 | 10 | Brock Coyle | LB | Shoulder | — |
| 2017 | 10 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 10 | Reuben Foster | LB | Ribs | — |
| 2017 | 10 | Brandon Fusco | G | Biceps | — |
| 2017 | 10 | Dontae Johnson | CB | Shoulder | — |
| 2017 | 10 | D.J. Jones | DT | Knee / Shoulder | — |
| 2017 | 10 | Kyle Juszczyk | RB | Neck | — |
| 2017 | 10 | Mark Nzeocha | LB | Neck | — |
| 2017 | 10 | Eric Reid | S | Knee | — |
| 2017 | 10 | Joe Staley | T | Eye | — |
| 2017 | 10 | George Kittle | TE | Ankle | Out |
| 2017 | 10 | Elijah Lee | LB | Knee | Out |
| 2017 | 10 | Trent Taylor | WR | Ribs | Out |
| 2017 | 10 | Aaron Lynch | DE | Calf | Out |
| 2017 | 10 | Solomon Thomas | DE | Knee | Questionable |
| 2017 | 10 | K'Waun Williams | CB | Quadricep | Questionable |
| 2017 | 12 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 12 | D.J. Jones | DT | Shoulder | — |
| 2017 | 12 | George Kittle | TE | Ankle | — |
| 2017 | 12 | Elijah Lee | LB | Knee | — |
| 2017 | 12 | Eric Reid | S | Knee | — |
| 2017 | 12 | Joe Staley | T | Not Injury Related | — |
| 2017 | 12 | Adrian Colbert | S | Thumb | Out |
| 2017 | 12 | Trenton Brown | T | Shoulder | Questionable |
| 2017 | 12 | Raheem Mostert | RB | Shoulder | Questionable |
| 2017 | 12 | Trent Taylor | WR | Ribs | Questionable |
| 2017 | 12 | Solomon Thomas | DE | Knee | Questionable |
| 2017 | 13 | C.J. Beathard | QB | Knee / Hip | — |
| 2017 | 13 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 13 | George Kittle | TE | Ankle | — |
| 2017 | 13 | Earl Mitchell | DT | Not Injury Related | — |
| 2017 | 13 | Eric Reid | S | Knee | — |
| 2017 | 13 | Joe Staley | T | Not Injury Related | — |
| 2017 | 13 | Solomon Thomas | DE | Knee | — |
| 2017 | 13 | Trenton Brown | T | Shoulder | Questionable |
| 2017 | 13 | Adrian Colbert | S | Thumb | Questionable |
| 2017 | 13 | Ahkello Witherspoon | CB | Ankle | Questionable |
| 2017 | 14 | DeForest Buckner | DT | Not Injury Related | — |
| 2017 | 14 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 14 | Earl Mitchell | DT | Not Injury Related | — |
| 2017 | 14 | Eric Reid | S | Knee | — |
| 2017 | 14 | Joe Staley | T | Not Injury Related | — |
| 2017 | 14 | Adrian Colbert | S | Thumb | — |
| 2017 | 14 | Trenton Brown | T | Shoulder | Questionable |
| 2017 | 15 | DeForest Buckner | DT | Not Injury Related | — |
| 2017 | 15 | Garrett Celek | TE | Knee | — |
| 2017 | 15 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 15 | George Kittle | TE | Ankle | — |
| 2017 | 15 | Earl Mitchell | DT | Not Injury Related | — |
| 2017 | 15 | Eric Reid | S | Knee / Rib | — |
| 2017 | 15 | Joe Staley | T | Not Injury Related | — |
| 2017 | 15 | Adrian Colbert | S | Thumb / Thigh | — |
| 2017 | 15 | Louis Murphy | WR | Illness | — |
| 2017 | 15 | Mark Nzeocha | LB | Hamstring | — |
| 2017 | 15 | Trenton Brown | T | Shoulder | Out |
| 2017 | 15 | Greg Mabin | CB | Calf | Questionable |
| 2017 | 15 | Ahkello Witherspoon | CB | Knee | Questionable |
| 2017 | 16 | Matt Breida | RB | Knee | — |
| 2017 | 16 | DeForest Buckner | DT | Ankle | — |
| 2017 | 16 | Adrian Colbert | S | Concussion / Thigh | — |
| 2017 | 16 | Brock Coyle | LB | Elbow | — |
| 2017 | 16 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 16 | Marquise Goodwin | WR | Back | — |
| 2017 | 16 | George Kittle | TE | Ankle | — |
| 2017 | 16 | Earl Mitchell | DT | Not Injury Related | — |
| 2017 | 16 | Eric Reid | S | Knee | — |
| 2017 | 16 | Aldrick Robinson | WR | Concussion / Wrist | — |
| 2017 | 16 | Joe Staley | T | Not Injury Related | — |
| 2017 | 16 | Ahkello Witherspoon | CB | Knee | — |
| 2017 | 16 | Mark Nzeocha | LB | Hamstring | — |
| 2017 | 16 | Trent Taylor | WR | Shoulder | — |
| 2017 | 16 | Greg Mabin | CB | Calf | Doubtful |
| 2017 | 16 | Garrett Celek | TE | Knee / Rib | Questionable |
| 2017 | 17 | DeForest Buckner | DT | Not Injury Related | — |
| 2017 | 17 | Elvis Dumervil | DE | Not Injury Related | — |
| 2017 | 17 | Reuben Foster | LB | Neck | — |
| 2017 | 17 | George Kittle | TE | Ankle | — |
| 2017 | 17 | Greg Mabin | CB | Calf | — |
| 2017 | 17 | Earl Mitchell | DT | Not Injury Related | — |
| 2017 | 17 | Eric Reid | S | Knee | — |
| 2017 | 17 | Joe Staley | T | Not Injury Related | — |
| 2017 | 17 | Garrett Celek | TE | Knee / Rib | — |
| 2017 | 17 | Adrian Colbert | S | Shoulder | — |
| 2017 | 17 | Marquise Goodwin | WR | Back | — |
| 2017 | 17 | Trent Taylor | WR | Shoulder | — |
| 2018 | 1 | Garry Gilliam | T | Concussion | — |
| 2018 | 1 | Jimmie Ward | S | Quadricep | — |
| 2018 | 1 | Erik Magnuson | T | Hamstring | Out |
| 2018 | 1 | Dekoda Watson | LB | Hamstring | Out |
| 2018 | 1 | Malcolm Smith | LB | Hamstring | Doubtful |
| 2018 | 2 | Joe Staley | T | Not Injury Related | — |
| 2018 | 2 | Ahkello Witherspoon | CB | Ankle | — |
| 2018 | 2 | Jaquiski Tartt | S | Shoulder | — |
| 2018 | 2 | K'Waun Williams | CB | Rib | — |
| 2018 | 2 | Joshua Garnett | G | Toe | Out |
| 2018 | 2 | Marquise Goodwin | WR | Quadricep | Out |
| 2018 | 2 | Erik Magnuson | C | Hamstring | Out |
| 2018 | 2 | Adrian Colbert | S | Hamstring | Questionable |
| 2018 | 2 | Mike Person | G | Foot | Questionable |
| 2018 | 2 | Malcolm Smith | LB | Hamstring | Questionable |
| 2018 | 3 | Richard Sherman | CB | Heel | — |
| 2018 | 3 | Joe Staley | T | Not Injury Related | — |
| 2018 | 3 | Ahkello Witherspoon | CB | Ankle / Hip | — |
| 2018 | 3 | Mike Person | G | Foot | — |
| 2018 | 3 | Cole Wick | TE | Knee | — |
| 2018 | 3 | Joshua Garnett | G | Toe | Out |
| 2018 | 3 | Marquise Goodwin | WR | Quadricep | Questionable |
| 2018 | 3 | Jaquiski Tartt | S | Shoulder | Questionable |
| 2018 | 4 | Marquise Goodwin | WR | Quadricep | — |
| 2018 | 4 | Mike Person | G | Knee | — |
| 2018 | 4 | Joe Staley | T | Not Injury Related | — |
| 2018 | 4 | Ahkello Witherspoon | CB | Ankle / Hip | — |
| 2018 | 4 | Joshua Garnett | G | Toe | Out |
| 2018 | 4 | Richard Sherman | CB | Calf | Out |
| 2018 | 4 | Jaquiski Tartt | S | Shoulder | Doubtful |
| 2018 | 4 | Antone Exum | S | Quadricep | Questionable |
| 2018 | 4 | Matt Breida | RB | Knee | Questionable |
| 2018 | 4 | Adrian Colbert | S | Hip | Questionable |
| 2018 | 4 | Alfred Morris | RB | Knee | Questionable |
| 2018 | 5 | Adrian Colbert | S | Hip | — |
| 2018 | 5 | Joshua Garnett | G | Toe | — |
| 2018 | 5 | Alfred Morris | RB | Knee | — |
| 2018 | 5 | Mike Person | G | Knee | — |
| 2018 | 5 | Jaquiski Tartt | S | Shoulder | — |
| 2018 | 5 | Ahkello Witherspoon | CB | Ankle / Hip | — |
| 2018 | 5 | Dante Pettis | WR | Knee | Out |
| 2018 | 5 | Jimmie Ward | CB | Hamstring | Questionable |
| 2018 | 5 | Mike McGlinchey | T | Knee | Questionable |
| 2018 | 5 | Weston Richburg | C | Knee | Questionable |
| 2018 | 5 | Joe Staley | T | Knee | Questionable |
| 2018 | 5 | Matt Breida | RB | Shoulder | Questionable |
| 2018 | 5 | Marquise Goodwin | WR | Hamstring / Quadricep | Questionable |
| 2018 | 5 | Richard Sherman | CB | Calf | Questionable |
| 2018 | 6 | Garrett Celek | TE | Quadricep | — |
| 2018 | 6 | Reuben Foster | LB | Shoulder | — |
| 2018 | 6 | Joshua Garnett | G | Toe | — |
| 2018 | 6 | Marquise Goodwin | WR | Hamstring / Quadricep | — |
| 2018 | 6 | Mike McGlinchey | T | Knee | — |
| 2018 | 6 | Richard Sherman | CB | Calf | — |
| 2018 | 6 | Jaquiski Tartt | S | Shoulder | — |
| 2018 | 6 | Jimmie Ward | CB | Hamstring | — |
| 2018 | 6 | Dante Pettis | WR | Knee | Out |
| 2018 | 6 | Trent Taylor | WR | Back | Doubtful |
| 2018 | 6 | K'Waun Williams | CB | Illness | Questionable |
| 2018 | 6 | Matt Breida | RB | Shoulder / Ankle | Questionable |
| 2018 | 6 | Pierre Garcon | WR | Shoulder / Knee | Questionable |
| 2018 | 6 | George Kittle | TE | Knee | Questionable |
| 2018 | 6 | Mike Person | G | Knee | Questionable |
| 2018 | 6 | Weston Richburg | C | Knee | Questionable |
| 2018 | 6 | Joe Staley | T | Knee | Questionable |
| 2018 | 7 | Matt Breida | RB | Shoulder / Ankle | — |
| 2018 | 7 | Reuben Foster | LB | Shoulder | — |
| 2018 | 7 | Joshua Garnett | G | Toe | — |
| 2018 | 7 | Marquise Goodwin | WR | Hamstring / Quadricep | — |
| 2018 | 7 | George Kittle | TE | Knee | — |
| 2018 | 7 | Mike Person | G | Knee | — |
| 2018 | 7 | Weston Richburg | C | Knee | — |
| 2018 | 7 | Joe Staley | T | Knee | — |
| 2018 | 7 | Jaquiski Tartt | S | Shoulder | — |
| 2018 | 7 | Dante Pettis | WR | Knee | Out |
| 2018 | 7 | Jimmie Ward | CB | Hamstring | Doubtful |
| 2018 | 7 | Richard Sherman | CB | Calf | Questionable |
| 2018 | 7 | Pierre Garcon | WR | Shoulder / Knee | Questionable |
| 2018 | 7 | Trent Taylor | WR | Back | Questionable |
| 2018 | 7 | K'Waun Williams | CB | Shoulder | Questionable |
| 2018 | 7 | Ahkello Witherspoon | CB | Concussion | Questionable |
| 2018 | 8 | Reuben Foster | LB | Shoulder | — |
| 2018 | 8 | Joshua Garnett | G | Toe | — |
| 2018 | 8 | Mike Person | G | Knee | — |
| 2018 | 8 | Dante Pettis | WR | Knee | — |
| 2018 | 8 | Joe Staley | T | Not Injury Related | — |
| 2018 | 8 | Jaquiski Tartt | S | Shoulder | — |
| 2018 | 8 | Solomon Thomas | DE | Thigh | — |
| 2018 | 8 | Jimmie Ward | CB | Hamstring | — |
| 2018 | 8 | Pierre Garcon | WR | Shoulder / Knee | Doubtful |
| 2018 | 8 | Weston Richburg | C | Knee | Questionable |
| 2018 | 8 | Matt Breida | RB | Ankle | Questionable |
| 2018 | 8 | Richard Sherman | CB | Calf | Questionable |
| 2018 | 9 | Mike Person | G | Ankle | — |
| 2018 | 9 | Joe Staley | T | Ankle | — |
| 2018 | 9 | Antone Exum | S | Concussion | Out |
| 2018 | 9 | Reuben Foster | LB | Hamstring | Out |
| 2018 | 9 | Jaquiski Tartt | S | Shoulder | Out |
| 2018 | 9 | C.J. Beathard | QB | right Wrist | Questionable |
| 2018 | 9 | Matt Breida | RB | Ankle | Questionable |
| 2018 | 9 | Pierre Garcon | WR | Shoulder / Knee | Questionable |
| 2018 | 9 | Raheem Mostert | RB | Ankle | Questionable |
| 2018 | 9 | Weston Richburg | C | Knee | Questionable |
| 2018 | 9 | Richard Sherman | CB | Calf / Heel | Questionable |
| 2018 | 10 | Garrett Celek | TE | Not Injury Related | — |
| 2018 | 10 | Joshua Garnett | G | Thumb | — |
| 2018 | 10 | Weston Richburg | C | Knee | — |
| 2018 | 10 | Joe Staley | T | Not Injury Related | — |
| 2018 | 10 | George Kittle | TE | Chest | — |
| 2018 | 10 | Reuben Foster | LB | Hamstring | Out |
| 2018 | 10 | Pierre Garcon | WR | Knee | Out |
| 2018 | 10 | Jaquiski Tartt | S | Shoulder | Out |
| 2018 | 12 | Weston Richburg | C | Knee | — |
| 2018 | 12 | Joe Staley | T | Not Injury Related | — |
| 2018 | 12 | Pierre Garcon | WR | Knee | Out |
| 2018 | 12 | Joshua Garnett | G | Thumb | Out |
| 2018 | 12 | Reuben Foster | LB | Hamstring | Questionable |
| 2018 | 13 | Arik Armstead | DE | Back | — |
| 2018 | 13 | Matt Breida | RB | Ankle | — |
| 2018 | 13 | Greg Mabin | CB | Thigh | — |
| 2018 | 13 | Earl Mitchell | DT | Not Injury Related | — |
| 2018 | 13 | Mark Nzeocha | LB | Thigh | — |
| 2018 | 13 | Weston Richburg | C | Knee | — |
| 2018 | 13 | Malcolm Smith | LB | Achilles | — |
| 2018 | 13 | Joe Staley | T | Not Injury Related | — |
| 2018 | 13 | Jaquiski Tartt | S | Shoulder | — |
| 2018 | 13 | Marquise Goodwin | WR | Not Injury Related | Out |
| 2018 | 13 | D.J. Reed | S | Heel / Chest | Out |
| 2018 | 13 | Pierre Garcon | WR | Knee | Out |
| 2018 | 13 | Joshua Garnett | G | Thumb | Out |
| 2018 | 14 | Dekoda Watson | LB | Calf | — |
| 2018 | 14 | Antone Exum | S | Knee | — |
| 2018 | 14 | Joshua Garnett | G | Thumb | — |
| 2018 | 14 | Mark Nzeocha | LB | Thigh | — |
| 2018 | 14 | D.J. Reed | S | Heel / Chest | — |
| 2018 | 14 | Weston Richburg | C | Knee | — |
| 2018 | 14 | Malcolm Smith | LB | Achilles | — |
| 2018 | 14 | Joe Staley | T | Not Injury Related | — |
| 2018 | 14 | Laken Tomlinson | G | Hip | — |
| 2018 | 14 | Matt Breida | RB | Ankle | Out |
| 2018 | 14 | Pierre Garcon | WR | Knee | Out |
| 2018 | 14 | Jaquiski Tartt | S | Shoulder | Out |
| 2018 | 14 | K'Waun Williams | CB | Knee | Questionable |
| 2018 | 15 | D.J. Jones | DT | Back | — |
| 2018 | 15 | Weston Richburg | C | Knee | — |
| 2018 | 15 | Joe Staley | T | Not Injury Related | — |
| 2018 | 15 | Laken Tomlinson | G | Hip | — |
| 2018 | 15 | Ronald Blair | DE | Groin | — |
| 2018 | 15 | Malcolm Smith | LB | Achilles | — |
| 2018 | 15 | Jaquiski Tartt | S | Shoulder | Out |
| 2018 | 15 | Matt Breida | RB | Ankle | Questionable |
| 2018 | 15 | Marquise Goodwin | WR | Calf | Questionable |
| 2018 | 15 | Cassius Marsh | DE | Concussion | Questionable |
| 2018 | 15 | Mark Nzeocha | LB | Groin | Questionable |
| 2018 | 15 | Dante Pettis | WR | Foot | Questionable |
| 2018 | 15 | K'Waun Williams | CB | Knee | Questionable |
| 2018 | 16 | Antone Exum | S | Hip | — |
| 2018 | 16 | Weston Richburg | C | Knee | — |
| 2018 | 16 | Joe Staley | T | Not Injury Related | — |
| 2018 | 16 | K'Waun Williams | CB | Knee | — |
| 2018 | 16 | Matt Breida | RB | Ankle | — |
| 2018 | 16 | Mark Nzeocha | LB | Groin | — |
| 2018 | 16 | Malcolm Smith | LB | Achilles | — |
| 2018 | 16 | Jaquiski Tartt | S | Shoulder | Out |
| 2018 | 17 | Arik Armstead | DE | Hand | — |
| 2018 | 17 | Weston Richburg | C | Knee | — |
| 2018 | 17 | Joe Staley | T | Not Injury Related | — |
| 2018 | 17 | Erik Magnuson | C | Hamstring | — |
| 2018 | 17 | Mark Nzeocha | LB | Groin | — |
| 2018 | 17 | Mike Person | G | Illness | — |
| 2018 | 17 | Malcolm Smith | LB | Achilles | — |
| 2018 | 17 | K'Waun Williams | CB | Knee | — |
| 2018 | 17 | Matt Breida | RB | Ankle | Out |
| 2018 | 17 | Marquise Goodwin | WR | Calf | Out |
| 2018 | 17 | Dante Pettis | WR | Knee | Out |
| 2018 | 17 | Garrett Celek | TE | Concussion | Out |
| 2018 | 17 | Tarvarius Moore | CB | Shoulder | Questionable |
| 2019 | 1 | Dee Ford | DE | Knee | — |
| 2019 | 1 | Dante Pettis | WR | Groin | — |
| 2019 | 1 | Joe Staley | T | Not Injury Related | — |
| 2019 | 1 | Jalen Hurd | WR | Back | Out |
| 2019 | 1 | Trent Taylor | WR | Foot | Out |
| 2019 | 1 | Jimmie Ward | CB | Hand | Out |
| 2019 | 1 | Nick Bosa | DE | Ankle | Questionable |
| 2019 | 1 | Weston Richburg | C | Knee | Questionable |
| 2019 | 1 | Jason Verrett | CB | Ankle | Questionable |
| 2019 | 1 | K'Waun Williams | CB | Knee | Questionable |
| 2019 | 2 | Mark Nzeocha | LB | Illness | — |
| 2019 | 2 | Joe Staley | T | Not Injury Related | — |
| 2019 | 2 | Tevin Coleman | RB | Ankle | Out |
| 2019 | 2 | Jalen Hurd | WR | Back | Out |
| 2019 | 2 | Trent Taylor | WR | Foot | Out |
| 2019 | 2 | Nick Bosa | DE | Ankle | Questionable |
| 2019 | 2 | Jimmie Ward | S | Hand | Questionable |
| 2019 | 3 | Richard Sherman | CB | Not Injury Related | — |
| 2019 | 3 | Tevin Coleman | RB | Ankle | Out |
| 2019 | 3 | Jalen Hurd | WR | Back | Out |
| 2019 | 3 | Joe Staley | T | Fibula | Out |
| 2019 | 3 | Trent Taylor | WR | Foot | Out |
| 2019 | 3 | Nick Bosa | DE | Ankle | Questionable |
| 2019 | 3 | Dee Ford | DE | Quadricep | Questionable |
| 2019 | 3 | Jaquiski Tartt | S | Toe | Questionable |
| 2019 | 3 | Jimmie Ward | S | Hand | Questionable |
| 2019 | 5 | Joe Staley | T | Fibula | Out |
| 2019 | 5 | Ahkello Witherspoon | CB | Foot | Out |
| 2019 | 5 | Tevin Coleman | RB | Ankle | Questionable |
| 2019 | 5 | Dee Ford | DE | Quadricep | Questionable |
| 2019 | 6 | Marquise Goodwin | WR | Not Injury Related | — |
| 2019 | 6 | Dee Ford | DE | Quadricep | — |
| 2019 | 6 | Kyle Juszczyk | RB | Knee | Out |
| 2019 | 6 | Mike McGlinchey | T | Knee | Out |
| 2019 | 6 | Joe Staley | T | Fibula | Out |
| 2019 | 6 | Ahkello Witherspoon | CB | Foot | Out |
| 2019 | 6 | George Kittle | TE | Groin | Questionable |
| 2019 | 7 | DeForest Buckner | DT | Not Injury Related | — |
| 2019 | 7 | Dee Ford | DE | Quadricep | — |
| 2019 | 7 | George Kittle | TE | Groin | — |
| 2019 | 7 | K'Waun Williams | CB | Hand | — |
| 2019 | 7 | D.J. Jones | DT | Hamstring | Out |
| 2019 | 7 | Kyle Juszczyk | RB | Knee | Out |
| 2019 | 7 | Mike McGlinchey | T | Knee | Out |
| 2019 | 7 | Deebo Samuel | WR | Groin | Out |
| 2019 | 7 | Joe Staley | T | Fibula | Out |
| 2019 | 7 | Ahkello Witherspoon | CB | Foot | Out |
| 2019 | 7 | Raheem Mostert | RB | Knee | Questionable |
| 2019 | 8 | D.J. Jones | DT | Hamstring | — |
| 2019 | 8 | George Kittle | TE | Groin | — |
| 2019 | 8 | Dante Pettis | WR | Knee | — |
| 2019 | 8 | Deebo Samuel | WR | Groin | — |
| 2019 | 8 | Dee Ford | DE | Quadricep | — |
| 2019 | 8 | Kyle Juszczyk | RB | Knee | Out |
| 2019 | 8 | Mike McGlinchey | T | Knee | Out |
| 2019 | 8 | Ahkello Witherspoon | CB | Foot | Out |
| 2019 | 8 | Joe Staley | T | Fibula | Doubtful |
| 2019 | 8 | Marquise Goodwin | WR | Not Injury Related | Questionable |
| 2019 | 8 | Raheem Mostert | RB | Knee | Questionable |
| 2019 | 8 | Levine Toilolo | TE | Groin | Questionable |
| 2019 | 9 | Dee Ford | DE | Quadricep | — |
| 2019 | 9 | Justin Skule | T | Knee / Foot | — |
| 2019 | 9 | Kyle Juszczyk | RB | Knee | Out |
| 2019 | 9 | Mike McGlinchey | T | Knee | Out |
| 2019 | 9 | Ahkello Witherspoon | CB | Foot | Out |
| 2019 | 9 | Joe Staley | T | Fibula | Doubtful |
| 2019 | 9 | Matt Breida | RB | Ankle | Questionable |
| 2019 | 9 | Raheem Mostert | RB | Knee | Questionable |
| 2019 | 9 | Levine Toilolo | TE | Groin | Questionable |
| 2019 | 10 | Matt Breida | RB | Ankle | — |
| 2019 | 10 | Dee Ford | DE | Quadricep | — |
| 2019 | 10 | Kyle Juszczyk | RB | Knee | — |
| 2019 | 10 | Levine Toilolo | TE | Groin | — |
| 2019 | 10 | Robbie Gould | K | right Quadricep | Doubtful |
| 2019 | 10 | George Kittle | TE | Knee / Ankle | Doubtful |
| 2019 | 10 | Mike McGlinchey | T | Knee | Questionable |
| 2019 | 10 | Raheem Mostert | RB | Knee | Questionable |
| 2019 | 10 | Joe Staley | T | Fibula | Questionable |
| 2019 | 10 | Ahkello Witherspoon | CB | Foot / Quadricep | Questionable |
| 2019 | 11 | Garrett Celek | TE | Back | — |
| 2019 | 11 | Tevin Coleman | RB | Not Injury Related | — |
| 2019 | 11 | Dee Ford | DE | Quadricep | — |
| 2019 | 11 | Levine Toilolo | TE | Groin | — |
| 2019 | 11 | D.J. Jones | DT | Groin | Out |
| 2019 | 11 | Joe Staley | T | Finger | Out |
| 2019 | 11 | Azeez Al-Shaair | LB | Concussion | Out |
| 2019 | 11 | Matt Breida | RB | Ankle | Doubtful |
| 2019 | 11 | Robbie Gould | K | right Quadricep | Doubtful |
| 2019 | 11 | George Kittle | TE | Knee / Ankle | Doubtful |
| 2019 | 11 | Emmanuel Sanders | WR | Ribs | Questionable |
| 2019 | 11 | Raheem Mostert | RB | Knee | Questionable |
| 2019 | 11 | Dante Pettis | WR | Back | Questionable |
| 2019 | 11 | Ahkello Witherspoon | CB | Foot / Quadricep | Questionable |
| 2019 | 12 | Azeez Al-Shaair | LB | Concussion | — |
| 2019 | 12 | D.J. Jones | DT | Groin | — |
| 2019 | 12 | Raheem Mostert | RB | Knee | — |
| 2019 | 12 | Dee Ford | DE | Quadricep / Hamstring | Out |
| 2019 | 12 | Joe Staley | T | Finger | Out |
| 2019 | 12 | Matt Breida | RB | Ankle | Doubtful |
| 2019 | 12 | Robbie Gould | K | right Quadricep | Doubtful |
| 2019 | 12 | George Kittle | TE | Knee / Ankle | Questionable |
| 2019 | 12 | Deebo Samuel | WR | Shoulder | Questionable |
| 2019 | 12 | Emmanuel Sanders | WR | Ribs | Questionable |
| 2019 | 13 | Robbie Gould | K | right Quadricep | — |
| 2019 | 13 | Jullian Taylor | DT | Jaw | — |
| 2019 | 13 | George Kittle | TE | Knee / Ankle | — |
| 2019 | 13 | Deebo Samuel | WR | Shoulder | — |
| 2019 | 13 | Emmanuel Sanders | WR | Ribs | — |
| 2019 | 13 | Dee Ford | DE | Quadricep / Hamstring | Out |
| 2019 | 13 | Dante Pettis | WR | Knee | Out |
| 2019 | 13 | Matt Breida | RB | Ankle | Questionable |
| 2019 | 13 | Joe Staley | T | Finger | Questionable |
| 2019 | 14 | Arik Armstead | DE | Not Injury Related | — |
| 2019 | 14 | Matt Breida | RB | Ankle | — |
| 2019 | 14 | Dee Ford | DE | Quadricep / Hamstring | — |
| 2019 | 14 | D.J. Jones | DT | Ankle | — |
| 2019 | 14 | George Kittle | TE | Knee / Ankle | — |
| 2019 | 14 | Deebo Samuel | WR | Shoulder | — |
| 2019 | 14 | Emmanuel Sanders | WR | Ribs | — |
| 2019 | 14 | Richard Sherman | CB | Knee | — |
| 2019 | 14 | Jaquiski Tartt | S | Ribs | Out |
| 2019 | 14 | Jullian Taylor | DT | Elbow | Out |
| 2019 | 14 | Marquise Goodwin | WR | Knee / Foot | Questionable |
| 2019 | 14 | Dante Pettis | WR | Knee | Questionable |
| 2019 | 14 | Joe Staley | T | Finger | Questionable |
| 2019 | 15 | Garrett Celek | TE | Back | — |
| 2019 | 15 | Dante Pettis | WR | Knee | — |
| 2019 | 15 | Dee Ford | DE | Quadricep / Hamstring | Out |
| 2019 | 15 | D.J. Jones | DT | Ankle | Out |
| 2019 | 15 | Richard Sherman | CB | Hamstring | Out |
| 2019 | 15 | Jaquiski Tartt | S | Ribs | Out |
| 2019 | 15 | Jullian Taylor | DT | Elbow | Out |
| 2019 | 15 | K'Waun Williams | CB | Concussion | Out |
| 2019 | 16 | Richard Sherman | CB | Hamstring | — |
| 2019 | 16 | K'Waun Williams | CB | Concussion | — |
| 2019 | 16 | Dee Ford | DE | Quadricep / Hamstring | Out |
| 2019 | 16 | Jaquiski Tartt | S | Ribs | Out |
| 2019 | 16 | Jullian Taylor | DT | Elbow | Out |
| 2019 | 16 | Mike Person | G | Neck | Questionable |
| 2019 | 17 | Azeez Al-Shaair | LB | Knee | — |
| 2019 | 17 | Tarvarius Moore | CB | Concussion | — |
| 2019 | 17 | Deebo Samuel | WR | Shoulder | — |
| 2019 | 17 | Dee Ford | DE | Quadricep / Hamstring | Out |
| 2019 | 17 | Jullian Taylor | DT | Elbow / Knee | Out |
| 2019 | 17 | Jaquiski Tartt | S | Ribs | Doubtful |
| 2019 | 17 | Mike Person | G | Neck | Questionable |
| 2019 | 19 (DIV) | Elijah Lee | LB | Illness | — |
| 2019 | 19 (DIV) | Mike Person | G | Neck | — |
| 2019 | 19 (DIV) | Dee Ford | DE | Quadricep / Hamstring | Questionable |
| 2019 | 19 (DIV) | Kentavius Street | DE | Knee | Questionable |
| 2019 | 20 (CONF) | Tevin Coleman | RB | Elbow | — |
| 2019 | 20 (CONF) | Dee Ford | DE | Quadricep / Hamstring | — |
| 2019 | 20 (CONF) | George Kittle | TE | Ankle | — |
| 2019 | 20 (CONF) | Raheem Mostert | RB | Calf | — |
| 2019 | 20 (CONF) | Kwon Alexander | LB | Pectoral | — |
| 2019 | 21 (SB) | Kwon Alexander | LB | Pectoral | — |
| 2019 | 21 (SB) | Tevin Coleman | RB | Shoulder | — |
| 2019 | 21 (SB) | Jaquiski Tartt | S | Ribs | — |
| 2020 | 1 | Tevin Coleman | RB | Not Injury Related | — |
| 2020 | 1 | Deebo Samuel | WR | Foot | Out |
| 2020 | 1 | Jason Verrett | CB | Hamstring | Out |
| 2020 | 1 | Brandon Aiyuk | WR | Hamstring | Questionable |
| 2020 | 1 | Ben Garland | C | Ankle | Questionable |
| 2020 | 2 | Richie James | WR | Hamstring | — |
| 2020 | 2 | Brandon Aiyuk | WR | Hamstring | — |
| 2020 | 2 | Ben Garland | C | Ankle | — |
| 2020 | 2 | Ahkello Witherspoon | CB | Concussion | — |
| 2020 | 2 | George Kittle | TE | Knee | Out |
| 2020 | 2 | Jason Verrett | CB | Hamstring | Out |
| 2020 | 2 | Dee Ford | DE | Neck | Questionable |
| 2020 | 3 | Jason Verrett | CB | Hamstring | — |
| 2020 | 3 | Tevin Coleman | RB | Knee | Out |
| 2020 | 3 | Dee Ford | DE | Back | Out |
| 2020 | 3 | Jimmy Garoppolo | QB | Ankle | Out |
| 2020 | 3 | Dre Greenlaw | LB | Quadricep | Out |
| 2020 | 3 | Raheem Mostert | RB | Knee | Out |
| 2020 | 3 | George Kittle | TE | Knee | Out |
| 2020 | 3 | Ahkello Witherspoon | CB | Hamstring | Questionable |
| 2020 | 4 | George Kittle | TE | Knee | — |
| 2020 | 4 | Jerick McKinnon | RB | Ribs | — |
| 2020 | 4 | Dee Ford | DE | Back | Out |
| 2020 | 4 | Jimmy Garoppolo | QB | Ankle | Out |
| 2020 | 4 | Dre Greenlaw | LB | Quadricep | Out |
| 2020 | 4 | Emmanuel Moseley | CB | Concussion | Out |
| 2020 | 4 | Raheem Mostert | RB | Knee | Out |
| 2020 | 4 | Jordan Reed | TE | Knee | Out |
| 2020 | 4 | Ahkello Witherspoon | CB | Hamstring | Out |
| 2020 | 4 | K'Waun Williams | CB | Hip | Questionable |
| 2020 | 5 | Arik Armstead | DE | Not Injury Related | — |
| 2020 | 5 | Jimmy Garoppolo | QB | Ankle | — |
| 2020 | 5 | Dre Greenlaw | LB | Quadricep | — |
| 2020 | 5 | Dante Pettis | WR | Knee | — |
| 2020 | 5 | Trent Taylor | WR | Ankle | — |
| 2020 | 5 | Jimmie Ward | S | Wrist | — |
| 2020 | 5 | Ezekiel Ansah | DE | Biceps | Out |
| 2020 | 5 | Dontae Johnson | CB | Groin | Out |
| 2020 | 5 | Emmanuel Moseley | CB | Concussion | Out |
| 2020 | 5 | K'Waun Williams | CB | Knee / Hip | Out |
| 2020 | 5 | Deebo Samuel | WR | Illness | Questionable |
| 2020 | 5 | Raheem Mostert | RB | Knee | Questionable |
| 2020 | 5 | Ahkello Witherspoon | CB | Hamstring | Questionable |
| 2020 | 6 | Jimmy Garoppolo | QB | Ankle | — |
| 2020 | 6 | D.J. Jones | DT | Eye | — |
| 2020 | 6 | Kwon Alexander | LB | Ankle | Out |
| 2020 | 6 | Dontae Johnson | CB | Groin | Out |
| 2020 | 6 | Marcell Harris | S | Ankle | Questionable |
| 2020 | 6 | Jeffery Wilson | RB | Calf | Questionable |
| 2020 | 6 | Emmanuel Moseley | CB | Concussion | Questionable |
| 2020 | 7 | Dontae Johnson | CB | Groin | — |
| 2020 | 7 | Kwon Alexander | LB | Ankle | Out |
| 2020 | 7 | Raheem Mostert | RB | Ankle | Out |
| 2020 | 7 | Jaquiski Tartt | S | Groin | Out |
| 2020 | 7 | Jimmie Ward | S | Quadricep | Out |
| 2020 | 7 | Trent Williams | T | Ankle | Questionable |
| 2020 | 7 | Jeffery Wilson | RB | Calf | Questionable |
| 2020 | 8 | Mike McGlinchey | T | Not Injury Related | — |
| 2020 | 8 | Jason Verrett | CB | Not Injury Related | — |
| 2020 | 8 | Deebo Samuel | WR | Hamstring | Out |
| 2020 | 8 | Jaquiski Tartt | S | Groin | Out |
| 2020 | 8 | Jeffery Wilson | RB | Ankle | Out |
| 2020 | 8 | Richie James | WR | Ankle | Doubtful |
| 2020 | 8 | Kentavius Street | DE | Illness | Doubtful |
| 2020 | 8 | Kwon Alexander | LB | Ankle | Doubtful |
| 2020 | 8 | Jimmie Ward | S | Quadricep | Questionable |
| 2020 | 9 | Dante Pettis | WR | Shoulder | — |
| 2020 | 9 | Kwon Alexander | LB | Ankle | — |
| 2020 | 9 | Brandon Aiyuk | WR | Not Injury Related | Out |
| 2020 | 9 | Trent Williams | T | Not Injury Related | Out |
| 2020 | 9 | Tevin Coleman | RB | Knee | Out |
| 2020 | 9 | Demetrius Flannigan-Fowles | LB | Hamstring | Out |
| 2020 | 9 | Jimmy Garoppolo | QB | Ankle | Out |
| 2020 | 9 | George Kittle | TE | Foot | Out |
| 2020 | 9 | Deebo Samuel | WR | Hamstring | Out |
| 2020 | 9 | Richie James | WR | Ankle | Questionable |
| 2020 | 9 | Jaquiski Tartt | S | Groin | Questionable |
| 2020 | 10 | Tevin Coleman | RB | Knee | Out |
| 2020 | 10 | Demetrius Flannigan-Fowles | LB | Hamstring | Out |
| 2020 | 10 | Deebo Samuel | WR | Hamstring | Out |
| 2020 | 10 | K'Waun Williams | CB | Ankle | Out |
| 2020 | 10 | Trent Taylor | WR | Back | Questionable |
| 2020 | 10 | River Cracraft | WR | Quadricep | Questionable |
| 2020 | 12 | Arik Armstead | DE | Not Injury Related | — |
| 2020 | 12 | Hroniss Grasu | C | Not Injury Related | — |
| 2020 | 12 | Deebo Samuel | WR | Hamstring | — |
| 2020 | 12 | Tom Compton | G | Concussion | Out |
| 2020 | 12 | Demetrius Flannigan-Fowles | LB | Hamstring | Out |
| 2020 | 12 | K'Waun Williams | CB | Ankle | Out |
| 2020 | 12 | Tevin Coleman | RB | Knee | Out |
| 2020 | 12 | Azeez Al-Shaair | LB | Illness | Questionable |
| 2020 | 12 | Dre Greenlaw | LB | Illness | Questionable |
| 2020 | 12 | Jordan Reed | TE | Illness | Questionable |
| 2020 | 12 | Javon Kinlaw | DT | Not Injury Related | Questionable |
| 2020 | 13 | Brandon Aiyuk | WR | Not Injury Related | — |
| 2020 | 13 | D.J. Jones | DT | Not Injury Related | — |
| 2020 | 13 | Deebo Samuel | WR | Hamstring | — |
| 2020 | 13 | Jordan Willis | DE | Not Injury Related | — |
| 2020 | 13 | K'Waun Williams | CB | Ankle | Out |
| 2020 | 13 | Emmanuel Moseley | CB | Hamstring | Questionable |
| 2020 | 14 | Deebo Samuel | WR | Foot | — |
| 2020 | 14 | Tom Compton | T | Concussion | Out |
| 2020 | 14 | Kevin Givens | DT | Not Injury Related | Out |
| 2020 | 14 | Hroniss Grasu | C | Knee | Out |
| 2020 | 14 | D.J. Jones | DT | Ankle | Doubtful |
| 2020 | 14 | Emmanuel Moseley | CB | Hamstring | Doubtful |
| 2020 | 14 | K'Waun Williams | CB | Ankle | Questionable |
| 2020 | 15 | Daniel Brunskill | G | Shoulder | — |
| 2020 | 15 | D.J. Jones | DT | Ankle | — |
| 2020 | 15 | Raheem Mostert | RB | Ankle | — |
| 2020 | 15 | Hroniss Grasu | C | Knee | Out |
| 2020 | 15 | Deebo Samuel | WR | Hamstring | Out |
| 2020 | 15 | Emmanuel Moseley | CB | Hamstring | Questionable |
| 2020 | 15 | Fred Warner | LB | Stinger | Questionable |
| 2020 | 15 | K'Waun Williams | CB | Ankle | Questionable |
| 2020 | 16 | Richie James | WR | Ankle | — |
| 2020 | 16 | Jason Verrett | CB | Illness | — |
| 2020 | 16 | Raheem Mostert | RB | Ankle | Out |
| 2020 | 16 | Nick Mullens | QB | right Elbow | Out |
| 2020 | 16 | Deebo Samuel | WR | Hamstring | Out |
| 2020 | 16 | Richard Sherman | CB | Calf | Out |
| 2020 | 16 | Jimmie Ward | S | Concussion | Out |
| 2020 | 16 | Dion Jordan | DE | Knee | Doubtful |
| 2020 | 16 | Tarvarius Moore | S | Knee | Questionable |
| 2020 | 16 | Emmanuel Moseley | CB | Hamstring | Questionable |
| 2020 | 16 | Hroniss Grasu | C | Knee | Questionable |
| 2020 | 16 | Javon Kinlaw | DT | Knee | Questionable |
| 2020 | 17 | Trent Williams | T | Elbow | — |
| 2020 | 17 | Jordan Willis | DE | Ankle | — |
| 2020 | 17 | Dion Jordan | DE | Knee | — |
| 2020 | 17 | Justin Skule | T | Knee | — |
| 2020 | 17 | Jimmie Ward | S | Concussion | — |
| 2020 | 17 | Charlie Woerner | TE | Not Injury Related | — |
| 2020 | 17 | Brandon Aiyuk | WR | Ankle | Out |
| 2020 | 17 | Kevin Givens | DT | Not Injury Related | Out |
| 2020 | 17 | Dre Greenlaw | LB | Calf | Out |
| 2020 | 17 | Javon Kinlaw | DT | Knee | Out |
| 2020 | 17 | Deebo Samuel | WR | Hamstring | Out |
| 2020 | 17 | Richard Sherman | CB | Calf | Out |
| 2020 | 17 | K'Waun Williams | CB | Shin | Out |
| 2020 | 17 | Tarvarius Moore | S | Ankle | Questionable |
| 2020 | 17 | Emmanuel Moseley | CB | Hamstring | Questionable |
| 2020 | 17 | Mark Nzeocha | LB | Illness | Questionable |
| 2021 | 1 | Brandon Aiyuk | WR | Hamstring | — |
| 2021 | 1 | Aaron Banks | G | Shoulder | — |
| 2021 | 1 | Nick Bosa | DE | Knee | — |
| 2021 | 1 | Dee Ford | DE | Back | — |
| 2021 | 1 | Dre Greenlaw | LB | Hip | — |
| 2021 | 1 | Jason Verrett | CB | Foot | — |
| 2021 | 1 | Trey Lance | QB | right Finger | — |
| 2021 | 1 | Jalen Hurd | WR | Knee | Out |
| 2021 | 1 | Javon Kinlaw | DT | Knee | Doubtful |
| 2021 | 1 | Emmanuel Moseley | CB | Knee | Doubtful |
| 2021 | 1 | Kevin Givens | DT | Hip | Questionable |
| 2021 | 2 | Dee Ford | DE | Ankle | — |
| 2021 | 2 | Dre Greenlaw | LB | Groin | Out |
| 2021 | 2 | Emmanuel Moseley | CB | Knee | Doubtful |
| 2021 | 2 | Arik Armstead | DE | Adductor | Questionable |
| 2021 | 2 | Marcell Harris | LB | Oblique | Questionable |
| 2021 | 2 | Javon Kinlaw | DT | Knee | Questionable |
| 2021 | 3 | Josh Norman | CB | Ankle | — |
| 2021 | 3 | Trey Sermon | RB | Concussion | — |
| 2021 | 3 | Jimmie Ward | S | Not injury related - resting player | — |
| 2021 | 3 | Fred Warner | LB | Not injury related - resting player | — |
| 2021 | 3 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 3 | Kevin Givens | DT | Ankle | Out |
| 2021 | 3 | Jamycal Hasty | RB | Ankle | Out |
| 2021 | 3 | Elijah Mitchell | RB | Shoulder | Doubtful |
| 2021 | 3 | Arik Armstead | DE | Adductor | Questionable |
| 2021 | 3 | Javon Kinlaw | DT | Knee | Questionable |
| 2021 | 3 | Emmanuel Moseley | CB | Knee | Questionable |
| 2021 | 4 | Arik Armstead | DE | Adductor | — |
| 2021 | 4 | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 4 | K'Waun Williams | CB | Calf | Out |
| 2021 | 4 | Josh Norman | CB | Chest | Doubtful |
| 2021 | 4 | Javon Kinlaw | DT | Knee | Questionable |
| 2021 | 4 | George Kittle | TE | Calf | Questionable |
| 2021 | 4 | Elijah Mitchell | RB | Shoulder | Questionable |
| 2021 | 5 | Arik Armstead | DE | Not injury related - resting player | — |
| 2021 | 5 | D.J. Jones | DT | Knee | — |
| 2021 | 5 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 5 | Elijah Mitchell | RB | Shoulder | — |
| 2021 | 5 | Josh Norman | CB | Chest | — |
| 2021 | 5 | Trent Williams | T | Shoulder | — |
| 2021 | 5 | Jimmy Garoppolo | QB | Calf | Out |
| 2021 | 5 | K'Waun Williams | CB | Calf | Out |
| 2021 | 5 | George Kittle | TE | Calf | Doubtful |
| 2021 | 5 | Samson Ebukam | DE | Hamstring | Questionable |
| 2021 | 5 | Javon Kinlaw | DT | Knee | Questionable |
| 2021 | 7 | Jimmy Garoppolo | QB | Calf | — |
| 2021 | 7 | K'Waun Williams | CB | Calf | — |
| 2021 | 7 | Maurice Hurst | DT | Calf | Out |
| 2021 | 7 | Javon Kinlaw | DT | Knee | Out |
| 2021 | 7 | Trey Lance | QB | Knee | Out |
| 2021 | 7 | Trent Williams | T | Ankle / Elbow | Doubtful |
| 2021 | 7 | Marcell Harris | LB | Thumb | Questionable |
| 2021 | 8 | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 8 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 8 | Mitch Wishnowsky | P | Not injury related - personal matter | — |
| 2021 | 8 | Trey Lance | QB | Knee | — |
| 2021 | 8 | Deebo Samuel | WR | Calf | — |
| 2021 | 8 | Marcell Harris | LB | Thumb | — |
| 2021 | 8 | Maurice Hurst | DT | Calf | Out |
| 2021 | 8 | Javon Kinlaw | DT | Knee | Out |
| 2021 | 8 | Jaquiski Tartt | S | Knee | Out |
| 2021 | 8 | Azeez Al-Shaair | LB | Concussion | Doubtful |
| 2021 | 8 | Dee Ford | DE | Concussion | Doubtful |
| 2021 | 8 | Samson Ebukam | DE | Ankle | Questionable |
| 2021 | 8 | Trent Williams | T | Ankle / Elbow | Questionable |
| 2021 | 9 | Azeez Al-Shaair | LB | Concussion | — |
| 2021 | 9 | Marcell Harris | LB | Thumb | — |
| 2021 | 9 | Trent Williams | T | Ankle | — |
| 2021 | 9 | Maurice Hurst | DT | Calf | Out |
| 2021 | 9 | Jimmie Ward | S | Quadricep | Out |
| 2021 | 9 | Dee Ford | DE | Back | Questionable |
| 2021 | 9 | Elijah Mitchell | RB | Rib | Questionable |
| 2021 | 9 | Deebo Samuel | WR | Calf | Questionable |
| 2021 | 10 | Arik Armstead | DE | Neck | — |
| 2021 | 10 | Tom Compton | T | Not injury related - personal matter | — |
| 2021 | 10 | George Kittle | TE | Calf | — |
| 2021 | 10 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 10 | Elijah Mitchell | RB | Rib | — |
| 2021 | 10 | Emmanuel Moseley | CB | Neck | — |
| 2021 | 10 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 10 | Jamycal Hasty | RB | Ankle | Out |
| 2021 | 10 | Maurice Hurst | DT | Calf | Out |
| 2021 | 10 | Dre Kirkpatrick | CB | Ankle | Out |
| 2021 | 10 | Mohamed Sanu | WR | Knee | Out |
| 2021 | 10 | Tavon Wilson | S | Foot | Out |
| 2021 | 10 | Arden Key | DE | Oblique | Questionable |
| 2021 | 10 | Josh Norman | CB | Rib | Questionable |
| 2021 | 10 | Jimmie Ward | S | Quadricep | Questionable |
| 2021 | 11 | Jaylon Moore | T | Knee | — |
| 2021 | 11 | Josh Norman | CB | Rib | — |
| 2021 | 11 | Deebo Samuel | WR | Shin | — |
| 2021 | 11 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 11 | Jamycal Hasty | RB | Ankle | Out |
| 2021 | 11 | Maurice Hurst | DT | Calf | Out |
| 2021 | 11 | Elijah Mitchell | RB | Rib / Finger | Doubtful |
| 2021 | 12 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 12 | Josh Norman | CB | Rib | — |
| 2021 | 12 | Laken Tomlinson | G | Ankle | — |
| 2021 | 12 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 12 | Jamycal Hasty | RB | Ankle | Out |
| 2021 | 12 | Maurice Hurst | DT | Calf | Doubtful |
| 2021 | 12 | Elijah Mitchell | RB | Rib / Finger | Questionable |
| 2021 | 13 | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 13 | Jamycal Hasty | RB | Ankle | — |
| 2021 | 13 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 13 | Elijah Mitchell | RB | Rib / Finger | — |
| 2021 | 13 | Kentavius Street | DE | Wrist | — |
| 2021 | 13 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 13 | Dre Greenlaw | LB | Groin | Out |
| 2021 | 13 | Maurice Hurst | DT | Calf | Out |
| 2021 | 13 | Deebo Samuel | WR | Groin | Out |
| 2021 | 13 | Trey Sermon | RB | Ankle | Out |
| 2021 | 13 | Fred Warner | LB | Hamstring | Doubtful |
| 2021 | 13 | Marcell Harris | LB | Concussion | Questionable |
| 2021 | 14 | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 14 | Marcell Harris | LB | Concussion | — |
| 2021 | 14 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 14 | Fred Warner | LB | Hamstring | — |
| 2021 | 14 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 14 | Jeffery Wilson | RB | Knee | — |
| 2021 | 14 | Trenton Cannon | RB | Concussion | Out |
| 2021 | 14 | Dre Greenlaw | LB | Groin | Out |
| 2021 | 14 | Maurice Hurst | DT | Calf | Out |
| 2021 | 14 | Elijah Mitchell | RB | Concussion / Knee | Out |
| 2021 | 14 | Emmanuel Moseley | CB | Ankle | Out |
| 2021 | 14 | Dontae Johnson | CB | Not injury related - personal matter | Questionable |
| 2021 | 14 | Deebo Samuel | WR | Groin | Questionable |
| 2021 | 15 | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 15 | Dontae Johnson | CB | Not injury related - personal matter | — |
| 2021 | 15 | George Kittle | TE | Knee | — |
| 2021 | 15 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 15 | Fred Warner | LB | Ankle | — |
| 2021 | 15 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 15 | Dre Greenlaw | LB | Groin | Out |
| 2021 | 15 | Maurice Hurst | DT | Calf | Out |
| 2021 | 15 | Elijah Mitchell | RB | Concussion / Knee | Out |
| 2021 | 15 | Azeez Al-Shaair | LB | Elbow | Doubtful |
| 2021 | 15 | Ambry Thomas | CB | Concussion | Questionable |
| 2021 | 15 | D.J. Jones | DT | Knee | Questionable |
| 2021 | 15 | Jaquiski Tartt | S | Glute | Questionable |
| 2021 | 16 | Jaquiski Tartt | S | Ankle | — |
| 2021 | 16 | Dre Greenlaw | LB | Groin | Out |
| 2021 | 16 | Talanoa Hufanga | S | Knee | Out |
| 2021 | 16 | Maurice Hurst | DT | Calf | Out |
| 2021 | 16 | Elijah Mitchell | RB | Knee | Out |
| 2021 | 16 | Azeez Al-Shaair | LB | Elbow | Questionable |
| 2021 | 17 | D.J. Jones | DT | Ankle | — |
| 2021 | 17 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 17 | Trent Williams | T | Not injury related - resting player | — |
| 2021 | 17 | Azeez Al-Shaair | LB | Knee | Out |
| 2021 | 17 | Dre Greenlaw | LB | Groin | Out |
| 2021 | 17 | Maurice Hurst | DT | Calf | Out |
| 2021 | 17 | Jimmy Garoppolo | QB | right Thumb | Doubtful |
| 2021 | 17 | Talanoa Hufanga | S | Knee | Doubtful |
| 2021 | 17 | Elijah Mitchell | RB | Knee | Questionable |
| 2021 | 18 | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 18 | Talanoa Hufanga | S | Knee | — |
| 2021 | 18 | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 18 | Elijah Mitchell | RB | Knee | — |
| 2021 | 18 | Azeez Al-Shaair | LB | Knee | Questionable |
| 2021 | 18 | Trent Williams | T | Elbow | Questionable |
| 2021 | 18 | Jimmy Garoppolo | QB | right Thumb | Questionable |
| 2021 | 18 | Dre Greenlaw | LB | Groin | Questionable |
| 2021 | 18 | Marcell Harris | LB | Achilles | Questionable |
| 2021 | 18 | Maurice Hurst | DT | Calf | Questionable |
| 2021 | 18 | Jaquiski Tartt | S | Shoulder | Questionable |
| 2021 | 19 (WC) | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 19 (WC) | Jimmy Garoppolo | QB | right Thumb | — |
| 2021 | 19 (WC) | Dre Greenlaw | LB | Groin | — |
| 2021 | 19 (WC) | Maurice Hurst | DT | Calf | — |
| 2021 | 19 (WC) | George Kittle | TE | Not injury related - resting player | — |
| 2021 | 19 (WC) | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 19 (WC) | Elijah Mitchell | RB | Knee | — |
| 2021 | 19 (WC) | Jaquiski Tartt | S | Groin | — |
| 2021 | 19 (WC) | Trent Williams | T | Elbow | — |
| 2021 | 19 (WC) | Azeez Al-Shaair | LB | Knee | Questionable |
| 2021 | 19 (WC) | Mitch Wishnowsky | P | Concussion | Questionable |
| 2021 | 19 (WC) | Marcell Harris | LB | Achilles | Questionable |
| 2021 | 19 (WC) | Talanoa Hufanga | S | Knee | Questionable |
| 2021 | 20 (DIV) | Azeez Al-Shaair | LB | Knee | — |
| 2021 | 20 (DIV) | Jimmy Garoppolo | QB | right Shoulder / right Thumb | — |
| 2021 | 20 (DIV) | Dre Greenlaw | LB | Groin | — |
| 2021 | 20 (DIV) | Marcell Harris | LB | Achilles | — |
| 2021 | 20 (DIV) | Talanoa Hufanga | S | Knee | — |
| 2021 | 20 (DIV) | Elijah Mitchell | RB | Knee | — |
| 2021 | 20 (DIV) | Fred Warner | LB | Ankle | — |
| 2021 | 20 (DIV) | Nick Bosa | DE | Concussion | Questionable |
| 2021 | 20 (DIV) | Ambry Thomas | CB | Knee | Questionable |
| 2021 | 20 (DIV) | Jordan Willis | DE | Ankle | Questionable |
| 2021 | 21 (CONF) | Nick Bosa | DE | Not injury related - resting player | — |
| 2021 | 21 (CONF) | Jimmy Garoppolo | QB | right Thumb | — |
| 2021 | 21 (CONF) | Alex Mack | C | Not injury related - resting player | — |
| 2021 | 21 (CONF) | Elijah Mitchell | RB | Knee | — |
| 2021 | 21 (CONF) | Ambry Thomas | CB | Knee | — |
| 2021 | 21 (CONF) | Trent Williams | T | Ankle | Questionable |
| 2021 | 21 (CONF) | Jeffery Wilson | RB | Ankle | Questionable |
| 2022 | 1 | Arik Armstead | DE | Knee | — |
| 2022 | 1 | Oren Burks | LB | Knee | — |
| 2022 | 1 | Jimmy Garoppolo | QB | right Shoulder | — |
| 2022 | 1 | Mike McGlinchey | T | Knee | — |
| 2022 | 1 | Dre Greenlaw | LB | Elbow | — |
| 2022 | 1 | Daniel Brunskill | G | Hamstring | Out |
| 2022 | 1 | George Kittle | TE | Groin | Questionable |
| 2022 | 2 | Dre Greenlaw | LB | Elbow | — |
| 2022 | 2 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 2 | Samuel Womack | CB | Eye | — |
| 2022 | 2 | Daniel Brunskill | G | Hamstring | Out |
| 2022 | 2 | George Kittle | TE | Groin | Questionable |
| 2022 | 3 | George Kittle | TE | Groin | — |
| 2022 | 3 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 3 | Daniel Brunskill | G | Hamstring | Out |
| 2022 | 3 | Tyrion Davis-Price | RB | Ankle | Out |
| 2022 | 3 | Tyler Kroft | TE | Knee | Out |
| 2022 | 3 | Arik Armstead | DE | Foot | Questionable |
| 2022 | 3 | Colton McKivitz | T | Ankle | Questionable |
| 2022 | 4 | Daniel Brunskill | G | Hamstring | — |
| 2022 | 4 | Jeffery Wilson | RB | Heel | — |
| 2022 | 4 | Azeez Al-Shaair | LB | Knee | Out |
| 2022 | 4 | Tyrion Davis-Price | RB | Ankle | Out |
| 2022 | 4 | Tyler Kroft | TE | Knee | Out |
| 2022 | 4 | Tarvarius Moore | S | Hamstring | Out |
| 2022 | 4 | Trent Williams | T | Ankle | Out |
| 2022 | 4 | Danny Gray | WR | Hip | Doubtful |
| 2022 | 4 | Arik Armstead | DE | Foot | Questionable |
| 2022 | 4 | Ross Dwelley | TE | Rib | Questionable |
| 2022 | 4 | Javon Kinlaw | DT | Knee | Questionable |
| 2022 | 5 | Nick Bosa | DE | Not injury related - resting player | — |
| 2022 | 5 | Ross Dwelley | TE | Rib | — |
| 2022 | 5 | Danny Gray | WR | Hip | — |
| 2022 | 5 | Jauan Jennings | WR | Ankle | — |
| 2022 | 5 | Arik Armstead | DE | Foot / Ankle | Out |
| 2022 | 5 | Tyrion Davis-Price | RB | Ankle | Out |
| 2022 | 5 | Javon Kinlaw | DT | Knee | Out |
| 2022 | 5 | Tyler Kroft | TE | Knee | Out |
| 2022 | 5 | Colton McKivitz | T | Knee | Out |
| 2022 | 5 | Tarvarius Moore | S | Hamstring | Out |
| 2022 | 5 | Trent Williams | T | Ankle | Out |
| 2022 | 6 | Tyrion Davis-Price | RB | Ankle | — |
| 2022 | 6 | Samson Ebukam | DE | Achilles | — |
| 2022 | 6 | Robbie Gould | K | left Knee | — |
| 2022 | 6 | Danny Gray | WR | Illness | — |
| 2022 | 6 | Deommodore Lenoir | CB | Wrist | — |
| 2022 | 6 | Tarvarius Moore | S | Hamstring | — |
| 2022 | 6 | Jeffery Wilson | RB | Shoulder | — |
| 2022 | 6 | Arik Armstead | DT | Foot / Ankle | Out |
| 2022 | 6 | Javon Kinlaw | DT | Knee | Out |
| 2022 | 6 | Emmanuel Moseley | CB | Knee | Out |
| 2022 | 6 | Jimmie Ward | S | Hand | Out |
| 2022 | 6 | Trent Williams | T | Ankle | Out |
| 2022 | 6 | Aaron Banks | G | Knee | Questionable |
| 2022 | 6 | Nick Bosa | DE | Groin | Questionable |
| 2022 | 6 | Tyler Kroft | TE | Knee | Questionable |
| 2022 | 7 | Nick Bosa | DE | Groin | — |
| 2022 | 7 | Samson Ebukam | DE | Achilles | — |
| 2022 | 7 | Demetrius Flannigan-Fowles | LB | Knee | — |
| 2022 | 7 | Drake Jackson | DE | Knee | — |
| 2022 | 7 | Tyler Kroft | TE | Knee | — |
| 2022 | 7 | Mike McGlinchey | T | Calf | — |
| 2022 | 7 | Trent Williams | T | Ankle | — |
| 2022 | 7 | Charlie Woerner | TE | Shoulder | — |
| 2022 | 7 | Christian McCaffrey | RB | not injury related - travel | — |
| 2022 | 7 | Jimmie Ward | S | Hand | — |
| 2022 | 7 | Arik Armstead | DT | Foot / Ankle | Out |
| 2022 | 7 | Talanoa Hufanga | S | Concussion | Questionable |
| 2022 | 7 | Charvarius Ward | CB | Groin | Questionable |
| 2022 | 8 | Samson Ebukam | DE | Achilles | — |
| 2022 | 8 | Jimmie Ward | S | Hand | — |
| 2022 | 8 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 8 | Arik Armstead | DT | Foot / Ankle | Out |
| 2022 | 8 | Dre Greenlaw | LB | Calf | Out |
| 2022 | 8 | Kyle Juszczyk | FB | Finger | Out |
| 2022 | 8 | Deebo Samuel | WR | Hamstring | Out |
| 2022 | 8 | Jauan Jennings | WR | Hamstring | Questionable |
| 2022 | 8 | Jason Verrett | CB | Knee | Questionable |
| 2022 | 10 | Tyler Kroft | TE | Not injury related - personal matter | — |
| 2022 | 10 | Aaron Banks | G | Not injury related - personal matter | — |
| 2022 | 10 | Dre Greenlaw | LB | Calf | — |
| 2022 | 10 | Jauan Jennings | WR | Hamstring | — |
| 2022 | 10 | Kyle Juszczyk | FB | Finger | — |
| 2022 | 10 | Deebo Samuel | WR | Hamstring | — |
| 2022 | 10 | Jimmie Ward | S | Hand | — |
| 2022 | 10 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 10 | Arik Armstead | DT | Foot / Ankle | Out |
| 2022 | 10 | Jason Verrett | CB | Knee / Achilles | Out |
| 2022 | 10 | Samson Ebukam | DE | Quadricep / Achilles | Doubtful |
| 2022 | 11 | Nick Bosa | DE | Not injury related - resting player | — |
| 2022 | 11 | Danny Gray | WR | Ankle | — |
| 2022 | 11 | Charvarius Ward | CB | Not injury related - personal matter | — |
| 2022 | 11 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 11 | Arik Armstead | DT | Foot / Ankle | Out |
| 2022 | 11 | Samson Ebukam | DE | Quadricep / Achilles | Questionable |
| 2022 | 12 | Samson Ebukam | DE | Quadricep / Achilles | — |
| 2022 | 12 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 12 | Arik Armstead | DT | Foot / Ankle | Doubtful |
| 2022 | 12 | Deebo Samuel | WR | Hamstring | Questionable |
| 2022 | 13 | Arik Armstead | DT | Foot / Ankle | — |
| 2022 | 13 | Jimmy Garoppolo | QB | Knee | — |
| 2022 | 13 | Christian McCaffrey | RB | Knee | — |
| 2022 | 13 | Elijah Mitchell | RB | Knee | Out |
| 2022 | 13 | Trent Williams | T | Back | Questionable |
| 2022 | 13 | Spencer Burford | G | Ankle | Questionable |
| 2022 | 13 | Charles Omenihu | DE | Knee | Questionable |
| 2022 | 13 | Deebo Samuel | WR | Quadricep | Questionable |
| 2022 | 14 | Arik Armstead | DT | Foot / Ankle | — |
| 2022 | 14 | Spencer Burford | G | Ankle | — |
| 2022 | 14 | Christian McCaffrey | RB | Knee | — |
| 2022 | 14 | Deebo Samuel | WR | Quadricep | — |
| 2022 | 14 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 14 | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 14 | Tarvarius Moore | S | Knee | Out |
| 2022 | 14 | Hassan Ridgeway | DT | Pectoral | Out |
| 2022 | 14 | Nick Bosa | DE | Hamstring | Questionable |
| 2022 | 15 | Arik Armstead | DT | Foot / Ankle | — |
| 2022 | 15 | Christian McCaffrey | RB | Knee | — |
| 2022 | 15 | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 15 | Kevin Givens | DT | Knee | Out |
| 2022 | 15 | Tarvarius Moore | S | Knee | Out |
| 2022 | 15 | Hassan Ridgeway | DT | Pectoral | Out |
| 2022 | 15 | Deebo Samuel | WR | Ankle / Knee | Out |
| 2022 | 15 | Samuel Womack | CB | Concussion | Out |
| 2022 | 15 | Kerry Hyder | DE | Ankle | Questionable |
| 2022 | 15 | Brock Purdy | QB | Oblique / Rib | Questionable |
| 2022 | 15 | Ambry Thomas | CB | Ankle | Questionable |
| 2022 | 16 | Arik Armstead | DT | Foot / Ankle | — |
| 2022 | 16 | Danny Gray | WR | Hamstring | — |
| 2022 | 16 | Christian McCaffrey | RB | Knee | — |
| 2022 | 16 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 16 | Samuel Womack | CB | Concussion | — |
| 2022 | 16 | Brock Purdy | QB | Oblique / Rib | — |
| 2022 | 16 | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 16 | Kevin Givens | DT | Knee | Out |
| 2022 | 16 | Deebo Samuel | WR | Ankle / Knee | Out |
| 2022 | 16 | Tarvarius Moore | S | Illness / Knee | Questionable |
| 2022 | 16 | Kerry Hyder | DE | Ankle | Questionable |
| 2022 | 16 | Jordan Mason | RB | Hamstring | Questionable |
| 2022 | 16 | Ambry Thomas | CB | Ankle | Questionable |
| 2022 | 16 | Charvarius Ward | CB | Concussion | Questionable |
| 2022 | 17 | Arik Armstead | DT | Foot / Ankle | — |
| 2022 | 17 | Nick Bosa | DE | Illness | — |
| 2022 | 17 | Jordan Mason | RB | Hamstring | — |
| 2022 | 17 | Christian McCaffrey | RB | Knee | — |
| 2022 | 17 | Brock Purdy | QB | Oblique / Rib | — |
| 2022 | 17 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 17 | Mitch Wishnowsky | P | Illness | — |
| 2022 | 17 | Javon Kinlaw | DT | Knee | — |
| 2022 | 17 | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 17 | Kevin Givens | DT | Knee | Out |
| 2022 | 17 | Deebo Samuel | WR | Ankle / Knee | Out |
| 2022 | 17 | Kerry Hyder | DE | Ankle | Questionable |
| 2022 | 17 | Ambry Thomas | CB | Ankle / Illness | Questionable |
| 2022 | 18 | Nick Bosa | DE | Not injury related - resting player | — |
| 2022 | 18 | Christian McCaffrey | RB | Ankle / Knee | — |
| 2022 | 18 | Brock Purdy | QB | Oblique / Rib | — |
| 2022 | 18 | Deebo Samuel | WR | Ankle / Knee | — |
| 2022 | 18 | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 18 | Aaron Banks | G | Ankle / Knee | Out |
| 2022 | 18 | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 18 | Dre Greenlaw | LB | Back | Out |
| 2022 | 18 | Ambry Thomas | CB | Ankle | Out |
| 2022 | 18 | Kevin Givens | DT | Knee | Out |
| 2022 | 18 | Arik Armstead | DT | Foot / Ankle | Questionable |
| 2022 | 18 | Javon Kinlaw | DT | Illness / Knee | Questionable |
| 2022 | 19 (WC) | Arik Armstead | DT | Foot / Ankle | — |
| 2022 | 19 (WC) | Aaron Banks | G | Ankle / Knee | — |
| 2022 | 19 (WC) | Nick Bosa | DE | Not injury related - resting player | — |
| 2022 | 19 (WC) | Demetrius Flannigan-Fowles | LB | Neck | — |
| 2022 | 19 (WC) | Kevin Givens | DT | Knee | — |
| 2022 | 19 (WC) | Dre Greenlaw | LB | Back | — |
| 2022 | 19 (WC) | Javon Kinlaw | DT | Knee | — |
| 2022 | 19 (WC) | Christian McCaffrey | RB | Knee | — |
| 2022 | 19 (WC) | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 19 (WC) | Ambry Thomas | CB | Ankle | Out |
| 2022 | 20 (DIV) | Samson Ebukam | DE | Ankle | — |
| 2022 | 20 (DIV) | Jauan Jennings | WR | Ankle | — |
| 2022 | 20 (DIV) | Javon Kinlaw | DT | Knee | — |
| 2022 | 20 (DIV) | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 20 (DIV) | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 20 (DIV) | Ambry Thomas | CB | Ankle | Out |
| 2022 | 21 (CONF) | Christian McCaffrey | RB | Calf | — |
| 2022 | 21 (CONF) | Charles Omenihu | DE | Oblique | — |
| 2022 | 21 (CONF) | Deebo Samuel | WR | Ankle | — |
| 2022 | 21 (CONF) | Trent Williams | T | Not injury related - resting player | — |
| 2022 | 21 (CONF) | Jimmy Garoppolo | QB | Foot | Out |
| 2022 | 21 (CONF) | Elijah Mitchell | RB | Groin | Questionable |
| 2022 | 21 (CONF) | Ambry Thomas | CB | Ankle | Questionable |
| 2023 | 1 | Nick Bosa | DE | Not injury related - resting player | — |
| 2023 | 1 | Oren Burks | LB | Knee | — |
| 2023 | 1 | Jon Feliciano | C | Illness | — |
| 2023 | 1 | Tashaun Gipson | S | Back | — |
| 2023 | 1 | Talanoa Hufanga | S | Knee / Not injury related - personal | — |
| 2023 | 1 | Jordan Mason | RB | Foot | — |
| 2023 | 1 | Ray-Ray McCloud | WR | Wrist | — |
| 2023 | 1 | Jake Moody | K | right Quadricep | — |
| 2023 | 1 | George Odum | S | Shoulder | — |
| 2023 | 1 | Brock Purdy | QB | right Elbow | — |
| 2023 | 1 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 1 | George Kittle | TE | Groin | Questionable |
| 2023 | 1 | Charvarius Ward | CB | Heel | Questionable |
| 2023 | 2 | Dre Greenlaw | LB | Groin | — |
| 2023 | 2 | George Kittle | TE | Groin | — |
| 2023 | 2 | Ray-Ray McCloud | WR | Wrist | — |
| 2023 | 2 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 2 | Samuel Womack | CB | Knee | Out |
| 2023 | 3 | Brandon Aiyuk | WR | Shoulder | Questionable |
| 2023 | 3 | Ambry Thomas | CB | Knee | Questionable |
| 2023 | 4 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 4 | Brandon Aiyuk | WR | Shoulder | — |
| 2023 | 4 | Ambry Thomas | CB | Knee | — |
| 2023 | 4 | Jauan Jennings | WR | Shin | Doubtful |
| 2023 | 4 | Elijah Mitchell | RB | Knee | Questionable |
| 2023 | 4 | Demetrius Flannigan-Fowles | LB | Ankle | Questionable |
| 2023 | 4 | Dre Greenlaw | LB | Ankle | Questionable |
| 2023 | 4 | Deebo Samuel | WR | Ribs / Knee | Questionable |
| 2023 | 5 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2023 | 5 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 5 | Dre Greenlaw | LB | Ankle | — |
| 2023 | 5 | Jauan Jennings | WR | Shin | — |
| 2023 | 5 | Deebo Samuel | WR | Ribs / Knee | — |
| 2023 | 5 | Charvarius Ward | CB | Heel | — |
| 2023 | 5 | Elijah Mitchell | RB | Knee | Out |
| 2023 | 5 | Jon Feliciano | C | Concussion | Questionable |
| 2023 | 6 | George Kittle | TE | Not injury related - resting player | — |
| 2023 | 6 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 6 | Aaron Banks | G | Shoulder | — |
| 2023 | 6 | Dre Greenlaw | LB | Hamstring | Questionable |
| 2023 | 6 | Elijah Mitchell | RB | Knee | Questionable |
| 2023 | 7 | Aaron Banks | G | Ankle | — |
| 2023 | 7 | George Odum | S | Quadricep | — |
| 2023 | 7 | Isaiah Oliver | CB | Knee | — |
| 2023 | 7 | Deebo Samuel | WR | Shoulder | Out |
| 2023 | 7 | Trent Williams | T | Ankle | Doubtful |
| 2023 | 7 | Dre Greenlaw | LB | Hamstring | Questionable |
| 2023 | 7 | Christian McCaffrey | RB | Oblique | Questionable |
| 2023 | 8 | Dre Greenlaw | LB | Not injury related - resting player | — |
| 2023 | 8 | Demetrius Flannigan-Fowles | LB | Ankle | — |
| 2023 | 8 | Christian McCaffrey | RB | Oblique | — |
| 2023 | 8 | Deebo Samuel | WR | Shoulder | Out |
| 2023 | 8 | Trent Williams | T | Ankle | Questionable |
| 2023 | 8 | Brock Purdy | QB | Concussion | Questionable |
| 2023 | 10 | Dre Greenlaw | LB | Shoulder | — |
| 2023 | 10 | Ray-Ray McCloud | WR | Illness | — |
| 2023 | 10 | Deebo Samuel | WR | Shoulder | — |
| 2023 | 10 | Aaron Banks | G | Toe | Out |
| 2023 | 10 | Drake Jackson | DE | Knee | Out |
| 2023 | 10 | Demetrius Flannigan-Fowles | LB | Ankle | Questionable |
| 2023 | 10 | Robert Beal | DE | Hamstring | Questionable |
| 2023 | 10 | Darrell Luter | CB | Knee | Questionable |
| 2023 | 10 | Samuel Womack | CB | Knee | Questionable |
| 2023 | 10 | Javon Hargrave | DT | Knee | Questionable |
| 2023 | 10 | Trent Williams | T | Ankle | Questionable |
| 2023 | 11 | Demetrius Flannigan-Fowles | LB | Ankle | — |
| 2023 | 11 | Colton McKivitz | T | Ankle / Knee | — |
| 2023 | 11 | Trent Williams | T | Ankle / Not injury related - resting p | — |
| 2023 | 11 | Aaron Banks | G | Toe | Out |
| 2023 | 11 | Nick Zakelj | G | Biceps | Out |
| 2023 | 11 | Robert Beal | DE | Hamstring | Questionable |
| 2023 | 11 | Darrell Luter | CB | Knee | Questionable |
| 2023 | 11 | Samuel Womack | CB | Knee | Questionable |
| 2023 | 12 | Talanoa Hufanga | S | Knee | — |
| 2023 | 12 | Javon Hargrave | DT | Thumb | — |
| 2023 | 12 | Shemar Jean-Charles | CB | Shoulder | — |
| 2023 | 12 | Ray-Ray McCloud | WR | Rib | — |
| 2023 | 12 | Spencer Burford | G | Knee | Questionable |
| 2023 | 12 | Robert Beal | DE | Hamstring | Questionable |
| 2023 | 12 | Samuel Womack | CB | Knee | Questionable |
| 2023 | 12 | Aaron Banks | G | Toe | Questionable |
| 2023 | 13 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 13 | Spencer Burford | G | Knee | — |
| 2023 | 13 | Nick Bosa | DE | Toe | — |
| 2023 | 13 | Arik Armstead | DT | Foot | Questionable |
| 2023 | 13 | Jordan Mason | RB | Hamstring | Questionable |
| 2023 | 13 | Ray-Ray McCloud | WR | Rib | Questionable |
| 2023 | 14 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 14 | Arik Armstead | DT | Foot / Knee | Out |
| 2023 | 14 | Ross Dwelley | TE | Ankle | Out |
| 2023 | 14 | Ray-Ray McCloud | WR | Rib | Out |
| 2023 | 14 | Spencer Burford | G | Knee | Doubtful |
| 2023 | 14 | Darrell Luter | CB | Hamstring | Doubtful |
| 2023 | 14 | Elijah Mitchell | RB | Knee | Doubtful |
| 2023 | 15 | Ambry Thomas | CB | Not injury related - personal matter | — |
| 2023 | 15 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 15 | Darrell Luter | CB | Hamstring | — |
| 2023 | 15 | Arik Armstead | DT | Foot / Knee | Out |
| 2023 | 15 | Oren Burks | LB | Knee | Out |
| 2023 | 15 | Ross Dwelley | TE | Ankle | Out |
| 2023 | 15 | Javon Hargrave | DT | Hamstring | Out |
| 2023 | 15 | Elijah Mitchell | RB | Knee | Out |
| 2023 | 15 | Aaron Banks | G | Hip | Questionable |
| 2023 | 15 | Spencer Burford | G | Knee | Questionable |
| 2023 | 15 | Dre Greenlaw | LB | Hip / Ankle | Questionable |
| 2023 | 15 | Charvarius Ward | CB | Groin | Questionable |
| 2023 | 16 | Nick Bosa | DE | Not injury related - resting player | — |
| 2023 | 16 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 16 | Ben Bartch | G | Finger | — |
| 2023 | 16 | Spencer Burford | G | Knee | — |
| 2023 | 16 | Clelin Ferrell | DE | Ankle | — |
| 2023 | 16 | Deommodore Lenoir | CB | Rib | — |
| 2023 | 16 | Arik Armstead | DT | Foot / Knee | Out |
| 2023 | 16 | Oren Burks | LB | Knee | Out |
| 2023 | 16 | Ross Dwelley | TE | Ankle | Out |
| 2023 | 16 | Jauan Jennings | WR | Concussion | Out |
| 2023 | 16 | Javon Hargrave | DT | Hamstring | Questionable |
| 2023 | 16 | Elijah Mitchell | RB | Knee | Questionable |
| 2023 | 17 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2023 | 17 | Oren Burks | LB | Knee | — |
| 2023 | 17 | Dre Greenlaw | LB | Shoulder | — |
| 2023 | 17 | Javon Hargrave | DT | Hamstring | — |
| 2023 | 17 | Elijah Mitchell | RB | Knee | — |
| 2023 | 17 | Brock Purdy | QB | left Shoulder | — |
| 2023 | 17 | Deebo Samuel | WR | Neck | — |
| 2023 | 17 | Trent Williams | T | Groin | — |
| 2023 | 17 | Arik Armstead | DT | Foot / Knee | Out |
| 2023 | 17 | Ji'Ayir Brown | S | Knee | Out |
| 2023 | 17 | Ross Dwelley | TE | Ankle | Out |
| 2023 | 17 | Jauan Jennings | WR | Concussion | Out |
| 2023 | 17 | Jaylon Moore | T | Concussion | Out |
| 2023 | 17 | Aaron Banks | G | Toe | Questionable |
| 2023 | 17 | Demetrius Flannigan-Fowles | LB | Illness | Questionable |
| 2023 | 17 | Jordan Mason | RB | Illness | Questionable |
| 2023 | 17 | Danny Gray | WR | Shoulder | Questionable |
| 2023 | 17 | Ambry Thomas | CB | Knee / Hand | Questionable |
| 2023 | 18 | Nick Bosa | DE | Not injury related - resting player | — |
| 2023 | 18 | Trent Williams | T | Not injury related - resting player | — |
| 2023 | 18 | Aaron Banks | G | Toe | — |
| 2023 | 18 | Elijah Mitchell | RB | Illness | — |
| 2023 | 18 | Jaylon Moore | T | Concussion | — |
| 2023 | 18 | Arik Armstead | DT | Foot / Knee | Out |
| 2023 | 18 | Ji'Ayir Brown | S | Knee | Out |
| 2023 | 18 | Ross Dwelley | TE | Ankle | Out |
| 2023 | 18 | Tashaun Gipson | S | Quadricep | Out |
| 2023 | 18 | Christian McCaffrey | RB | Calf | Out |
| 2023 | 18 | Ambry Thomas | CB | Hand | Out |
| 2023 | 18 | Kyle Juszczyk | FB | Illness | Questionable |
| 2023 | 18 | Danny Gray | WR | Shoulder | Questionable |
| 2023 | 18 | Ray-Ray McCloud | WR | Rib | Questionable |
| 2023 | 18 | Jon Feliciano | C | Back | Questionable |
| 2023 | 18 | Jauan Jennings | WR | Concussion | Questionable |
| 2024 | 1 | Tatum Bethune | LB | Ankle | — |
| 2024 | 1 | Spencer Burford | G | Hand | — |
| 2024 | 1 | Isaac Guerendo | RB | Groin | — |
| 2024 | 1 | Jauan Jennings | WR | Ankle | — |
| 2024 | 1 | Mitch Wishnowsky | P | Back / Right Knee | — |
| 2024 | 1 | Yetur Gross-Matos | DE | Knee | Out |
| 2024 | 1 | Dee Winters | LB | Ankle | Out |
| 2024 | 1 | Talanoa Hufanga | S | Knee | Doubtful |
| 2024 | 1 | Aaron Banks | G | Finger | Questionable |
| 2024 | 1 | Christian McCaffrey | RB | Calf / Achilles | Questionable |
| 2024 | 2 | Aaron Banks | G | Finger / Calf | — |
| 2024 | 2 | Yetur Gross-Matos | DE | Knee | — |
| 2024 | 2 | Jauan Jennings | WR | Ankle | — |
| 2024 | 2 | Christian McCaffrey | RB | Calf / Achilles | Out |
| 2024 | 2 | Talanoa Hufanga | S | Knee | Doubtful |
| 2024 | 2 | Dee Winters | LB | Ankle | Questionable |
| 2024 | 3 | Talanoa Hufanga | S | Knee | — |
| 2024 | 3 | Dee Winters | LB | Ankle | — |
| 2024 | 3 | Deebo Samuel | WR | Calf | Out |
| 2024 | 3 | George Kittle | TE | Hamstring | Doubtful |
| 2024 | 3 | Nick Bosa | DE | Rib | Questionable |
| 2024 | 3 | Charvarius Ward | CB | Hamstring / Knee | Questionable |
| 2024 | 4 | Charvarius Ward | CB | Not injury related - personal matter | — |
| 2024 | 4 | Jacob Cowing | WR | Illness | — |
| 2024 | 4 | George Kittle | TE | Hamstring | — |
| 2024 | 4 | Brock Purdy | QB | Back | — |
| 2024 | 4 | Javon Hargrave | DT | Triceps | Out |
| 2024 | 4 | Curtis Robinson | LB | Knee | Out |
| 2024 | 4 | Talanoa Hufanga | S | Ankle | Questionable |
| 2024 | 4 | Trent Williams | T | Illness / Toe | Questionable |
| 2024 | 4 | Jordan Elliott | DT | Foot | Questionable |
| 2024 | 4 | Deebo Samuel | WR | Calf | Questionable |
| 2024 | 4 | Dee Winters | LB | Ankle | Questionable |
| 2024 | 5 | Jordan Elliott | DT | Knee | — |
| 2024 | 5 | Kevin Givens | DT | Triceps | — |
| 2024 | 5 | Talanoa Hufanga | S | Ankle | — |
| 2024 | 5 | Kyle Juszczyk | FB | Shoulder | — |
| 2024 | 5 | Trent Williams | T | Not injury related - resting player | — |
| 2024 | 5 | Dee Winters | LB | Ankle | — |
| 2024 | 5 | Demetrius Flannigan-Fowles | LB | Calf | Out |
| 2024 | 5 | Yetur Gross-Matos | DE | Knee | Out |
| 2024 | 5 | Chris Conley | WR | Oblique | Doubtful |
| 2024 | 5 | Isaac Yiadom | CB | Thigh | Questionable |
| 2024 | 5 | Kalia Davis | DT | Knee | Questionable |
| 2024 | 5 | Jacob Cowing | WR | Shoulder | Questionable |
| 2024 | 5 | George Kittle | TE | Ribs | Questionable |
| 2024 | 5 | Fred Warner | LB | Ankle | Questionable |
| 2024 | 6 | Ji'Ayir Brown | S | Ankle | — |
| 2024 | 6 | Jacob Cowing | WR | Shoulder | — |
| 2024 | 6 | George Kittle | TE | Ribs | — |
| 2024 | 6 | Fred Warner | LB | Ankle | — |
| 2024 | 6 | Jordan Elliott | DT | Knee | Out |
| 2024 | 6 | Demetrius Flannigan-Fowles | LB | Calf | Out |
| 2024 | 6 | Talanoa Hufanga | S | Wrist | Out |
| 2024 | 6 | Jake Moody | K | Right Ankle | Out |
| 2024 | 6 | Chris Conley | WR | Oblique | Questionable |
| 2024 | 6 | Charvarius Ward | CB | Knee | Questionable |
| 2024 | 7 | Maliek Collins | DT | Left Knee / Right Knee | — |
| 2024 | 7 | Jordan Elliott | DT | Knee | — |
| 2024 | 7 | Demetrius Flannigan-Fowles | LB | Calf | — |
| 2024 | 7 | Leonard Floyd | DE | Not injury related - resting player | — |
| 2024 | 7 | Jordan Mason | RB | Shoulder | — |
| 2024 | 7 | Malik Mustapha | S | Ankle | — |
| 2024 | 7 | Deebo Samuel | WR | Wrist | — |
| 2024 | 7 | Charvarius Ward | CB | Knee | — |
| 2024 | 7 | Trent Williams | T | Not injury related - resting player | — |
| 2024 | 7 | Jauan Jennings | WR | Hip | Out |
| 2024 | 7 | Jake Moody | K | Right Ankle | Out |
| 2024 | 7 | Matthew Wright | K | Shoulder / Back | Out |
| 2024 | 7 | Ricky Pearsall | WR | Chest | Questionable |
| 2024 | 7 | Kevin Givens | DT | Groin | Questionable |
| 2024 | 7 | Darrell Luter | CB | Pelvis | Questionable |
| 2024 | 8 | Nick Bosa | DE | Elbow | — |
| 2024 | 8 | Chris Conley | WR | Ankle | — |
| 2024 | 8 | Jordan Mason | RB | Shoulder | — |
| 2024 | 8 | Trent Williams | T | Not injury related - resting player | — |
| 2024 | 8 | Kevin Givens | DT | Groin | Out |
| 2024 | 8 | Jauan Jennings | WR | Hip | Out |
| 2024 | 8 | Jake Moody | K | Right Ankle | Out |
| 2024 | 8 | George Kittle | TE | Foot | Questionable |
| 2024 | 8 | Deommodore Lenoir | CB | Illness | Questionable |
| 2024 | 8 | George Odum | S | Knee | Questionable |
| 2024 | 8 | Deebo Samuel | WR | Wrist / Illness | Questionable |
| 2024 | 10 | Brandon Allen | QB | Left Finger | — |
| 2024 | 10 | Renardo Green | CB | Ankle | — |
| 2024 | 10 | Jauan Jennings | WR | Hip | — |
| 2024 | 10 | Jordan Mason | RB | Shoulder | — |
| 2024 | 10 | Jake Moody | K | Right Ankle | — |
| 2024 | 10 | Trent Williams | T | Not injury related - resting player | — |
| 2024 | 10 | Dee Winters | LB | Concussion | — |
| 2024 | 10 | Mitch Wishnowsky | P | Back | — |
| 2024 | 10 | Chris Conley | WR | Hamstring | Out |
| 2024 | 10 | Kevin Givens | DT | Groin | Out |
| 2024 | 10 | Charvarius Ward | CB | Not injury related - personal matter | Out |
| 2024 | 10 | Yetur Gross-Matos | DE | Knee | Out |
| 2024 | 10 | Christian McCaffrey | RB | Achilles | Questionable |
| 2024 | 10 | Nick Bosa | DE | Hip | Questionable |
| 2024 | 10 | Jon Feliciano | C | Knee | Questionable |
| 2024 | 10 | Malik Mustapha | S | Calf | Questionable |
| 2024 | 10 | Deebo Samuel | WR | Rib / Oblique | Questionable |
| 2024 | 11 | Chris Conley | WR | Hamstring | — |
| 2024 | 11 | Renardo Green | CB | Toe | — |
| 2024 | 11 | Jauan Jennings | WR | Ankle | — |
| 2024 | 11 | Christian McCaffrey | RB | Achilles | — |
| 2024 | 11 | Kevin Givens | DT | Groin | Out |
| 2024 | 11 | Charvarius Ward | CB | Not injury related - personal matter | Out |
| 2024 | 11 | Mitch Wishnowsky | P | Back | Out |
| 2024 | 11 | Darrell Luter | CB | Pelvis | Doubtful |
| 2024 | 11 | Trent Williams | T | Ankle | Questionable |
| 2024 | 11 | Yetur Gross-Matos | DE | Knee | Questionable |
| 2024 | 11 | Aaron Banks | G | Thigh | Questionable |
| 2024 | 11 | Nick Bosa | DE | Hip | Questionable |
| 2024 | 11 | Jon Feliciano | C | Knee | Questionable |
| 2024 | 11 | George Kittle | TE | Hamstring | Questionable |
| 2024 | 12 | George Kittle | TE | Hamstring | — |
| 2024 | 12 | Christian McCaffrey | RB | Not injury related - resting player / Achilles | — |
| 2024 | 12 | Tatum Bethune | LB | Knee | Out |
| 2024 | 12 | Nick Bosa | DE | Hip / Oblique | Out |
| 2024 | 12 | Jacob Cowing | WR | Concussion | Out |
| 2024 | 12 | Kevin Givens | DT | Groin | Out |
| 2024 | 12 | Brock Purdy | QB | Right Shoulder | Out |
| 2024 | 12 | Charvarius Ward | CB | Not injury related - personal matter | Out |
| 2024 | 12 | Trent Williams | T | Ankle | Questionable |
| 2024 | 12 | Jon Feliciano | C | Knee | Questionable |
| 2024 | 13 | Jacob Cowing | WR | Concussion | — |
| 2024 | 13 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2024 | 13 | Dominick Puni | G | Shoulder | — |
| 2024 | 13 | Charvarius Ward | CB | Not injury related - personal matter | — |
| 2024 | 13 | Aaron Banks | G | Concussion | Out |
| 2024 | 13 | Nick Bosa | DE | Hip / Oblique | Out |
| 2024 | 13 | Jordan Elliott | DT | Concussion | Out |
| 2024 | 13 | Deommodore Lenoir | CB | Knee | Out |
| 2024 | 13 | Trent Williams | T | Ankle | Out |
| 2024 | 13 | Dre Greenlaw | LB | Achilles | Out |
| 2024 | 13 | Brock Purdy | QB | Right Shoulder | Questionable |
| 2024 | 13 | Chris Conley | WR | Knee | Questionable |
| 2024 | 13 | Demetrius Flannigan-Fowles | LB | Knee | Questionable |
| 2024 | 13 | Kevin Givens | DT | Groin | Questionable |
| 2024 | 13 | Renardo Green | CB | Neck | Questionable |
| 2024 | 14 | Charvarius Ward | CB | Not injury related - personal matter | — |
| 2024 | 14 | Jordan Elliott | DT | Concussion | — |
| 2024 | 14 | Yetur Gross-Matos | DE | Knee | — |
| 2024 | 14 | Deommodore Lenoir | CB | Knee | — |
| 2024 | 14 | Sam Okuayinonu | DE | Wrist | — |
| 2024 | 14 | Dominick Puni | G | Shoulder | — |
| 2024 | 14 | Brock Purdy | QB | Right Shoulder | — |
| 2024 | 14 | Jordan Mason | RB | Ankle | Out |
| 2024 | 14 | George Odum | S | Knee | Out |
| 2024 | 14 | Trent Williams | T | Ankle | Out |
| 2024 | 14 | Dre Greenlaw | LB | Achilles | Out |
| 2024 | 14 | Nick Bosa | DE | Hip / Oblique | Doubtful |
| 2024 | 14 | Aaron Banks | G | Concussion | Questionable |
| 2024 | 14 | Demetrius Flannigan-Fowles | LB | Knee | Questionable |
| 2024 | 14 | Talanoa Hufanga | S | Wrist | Questionable |
| 2024 | 15 | Aaron Banks | G | Concussion | — |
| 2024 | 15 | Demetrius Flannigan-Fowles | LB | Knee | — |
| 2024 | 15 | Yetur Gross-Matos | DE | Knee | — |
| 2024 | 15 | Talanoa Hufanga | S | Wrist | — |
| 2024 | 15 | Sam Okuayinonu | DE | Wrist | — |
| 2024 | 15 | Dee Winters | LB | Ankle | — |
| 2024 | 15 | Ben Bartch | G | Ankle | Out |
| 2024 | 15 | Malik Mustapha | S | Chest / Shoulder | Out |
| 2024 | 15 | Trent Williams | T | Ankle | Out |
| 2024 | 15 | Dre Greenlaw | LB | Achilles | Questionable |
| 2024 | 15 | Nick Bosa | DE | Hip / Oblique | Questionable |
| 2024 | 15 | Khalil Davis | DT | Knee | Questionable |
| 2024 | 15 | Isaac Guerendo | RB | Foot | Questionable |
| 2024 | 16 | Aaron Banks | G | Elbow | — |
| 2024 | 16 | Ji'Ayir Brown | S | Groin | — |
| 2024 | 16 | Maliek Collins | DT | Illness | — |
| 2024 | 16 | Demetrius Flannigan-Fowles | LB | Knee | — |
| 2024 | 16 | Talanoa Hufanga | S | Wrist | — |
| 2024 | 16 | Jaylon Moore | T | Hip | — |
| 2024 | 16 | Malik Mustapha | S | Chest | — |
| 2024 | 16 | Dee Winters | LB | Neck | — |
| 2024 | 16 | Nick Zakelj | G | Illness | — |
| 2024 | 16 | Isaac Guerendo | RB | Foot / Hamstring | Out |
| 2024 | 16 | Trent Williams | T | Ankle | Out |
| 2024 | 16 | Robert Beal | DE | Ankle | Questionable |
| 2024 | 16 | Nick Bosa | DE | Hip / Oblique | Questionable |
| 2024 | 16 | Dre Greenlaw | LB | Achilles / Knee | Questionable |
| 2024 | 17 | Nick Bosa | DE | Hip / Oblique | — |
| 2024 | 17 | Jordan Elliott | DT | Knee | — |
| 2024 | 17 | Leonard Floyd | DE | Shoulder | — |
| 2024 | 17 | Isaac Guerendo | RB | Foot / Hamstring | — |
| 2024 | 17 | Talanoa Hufanga | S | Wrist | — |
| 2024 | 17 | Kyle Juszczyk | FB | Illness | — |
| 2024 | 17 | Dee Winters | LB | Chest | — |
| 2024 | 17 | Aaron Banks | G | Knee | Out |
| 2024 | 17 | Robert Beal | DE | Ankle | Out |
| 2024 | 17 | Spencer Burford | G | Calf | Out |
| 2024 | 17 | Dre Greenlaw | LB | Calf | Out |
| 2024 | 17 | Ji'Ayir Brown | S | Ankle | Questionable |
| 2024 | 17 | Colton McKivitz | T | Knee | Questionable |
| 2024 | 17 | Charvarius Ward | CB | Not injury related - personal matter | Questionable |
| 2024 | 17 | Tatum Bethune | LB | Knee | Questionable |
| 2024 | 18 | Nick Bosa | DE | Knee | — |
| 2024 | 18 | Leonard Floyd | DE | Shoulder | — |
| 2024 | 18 | Isaac Guerendo | RB | Foot / Hamstring | — |
| 2024 | 18 | Talanoa Hufanga | S | Wrist | — |
| 2024 | 18 | Ricky Pearsall | WR | Illness / Chest | — |
| 2024 | 18 | Robert Beal | DE | Ankle | Out |
| 2024 | 18 | Spencer Burford | G | Calf | Out |
| 2024 | 18 | Deommodore Lenoir | CB | Shoulder | Out |
| 2024 | 18 | Brock Purdy | QB | Right Elbow | Out |
| 2024 | 18 | Deebo Samuel | WR | Ribs / Wrist | Out |
| 2024 | 18 | Demetrius Flannigan-Fowles | LB | Calf | Doubtful |
| 2024 | 18 | Ji'Ayir Brown | S | Ankle | Questionable |
| 2024 | 18 | George Kittle | TE | Ankle / Hamstring | Questionable |
| 2024 | 18 | Colton McKivitz | T | Knee | Questionable |
| 2024 | 18 | Isaac Yiadom | CB | Pelvis | Questionable |
| 2025 | 1 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 1 | Christian McCaffrey | RB | Calf | Questionable |
| 2025 | 1 | Bryce Huff | DE | Ankle | — |
| 2025 | 1 | Jauan Jennings | WR | Calf | — |
| 2025 | 1 | Ben Bartch | G | Elbow | — |
| 2025 | 1 | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 1 | Jason Pinnock | S | Heel | — |
| 2025 | 1 | Mac Jones | QB | Knee | — |
| 2025 | 1 | Sam Okuayinonu | DE | Shoulder | — |
| 2025 | 1 | Kalia Davis | DT | Groin | — |
| 2025 | 1 | Dominick Puni | G | Knee | — |
| 2025 | 1 | Isaac Guerendo | RB | Shoulder | — |
| 2025 | 1 | Upton Stout | CB | Calf | — |
| 2025 | 1 | Jordan Watkins | WR | Ankle | Doubtful |
| 2025 | 1 | Jordan James | RB | Finger | Doubtful |
| 2025 | 1 | Mykel Williams | DE | Knee | — |
| 2025 | 1 | CJ West | DT | Knee | — |
| 2025 | 2 | Trent Williams | T | Knee | Questionable |
| 2025 | 2 | Christian McCaffrey | RB | Calf | — |
| 2025 | 2 | Luke Gifford | LB | Knee | — |
| 2025 | 2 | Nick Bosa | DE | Not injury related - resting player | — |
| 2025 | 2 | Jauan Jennings | WR | Shoulder | Questionable |
| 2025 | 2 | Ben Bartch | G | Knee / Elbow | — |
| 2025 | 2 | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 2 | Mac Jones | QB | Knee | — |
| 2025 | 2 | Brock Purdy | QB | Shoulder / Toe | Out |
| 2025 | 2 | Dominick Puni | G | Knee | — |
| 2025 | 2 | Jordan Watkins | WR | Ankle | — |
| 2025 | 2 | Jordan James | RB | Finger | — |
| 2025 | 3 | Trent Williams | T | Knee / Not injury related - resting player | — |
| 2025 | 3 | Kyle Juszczyk | FB | Concussion | — |
| 2025 | 3 | Christian McCaffrey | RB | Calf / Not injury related - resting player | — |
| 2025 | 3 | Siran Neal | S | Concussion | — |
| 2025 | 3 | Nick Bosa | DE | Not injury related - resting player | — |
| 2025 | 3 | Jauan Jennings | WR | Ankle / Shoulder | Questionable |
| 2025 | 3 | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 3 | Spencer Burford | T | Knee | Out |
| 2025 | 3 | Brock Purdy | QB | Shoulder / Toe | Questionable |
| 2025 | 3 | Jordan Watkins | WR | Calf | Out |
| 2025 | 3 | Jordan James | RB | Finger | — |
| 2025 | 3 | Connor Colby | G | Groin | Questionable |
| 2025 | 4 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 4 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 4 | Nick Bosa | DE | Knee | — |
| 2025 | 4 | Jauan Jennings | WR | Ankle / Shoulder | Questionable |
| 2025 | 4 | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 4 | Deommodore Lenoir | CB | Illness | — |
| 2025 | 4 | Mac Jones | QB | Knee | Questionable |
| 2025 | 4 | Kalia Davis | DT | Ankle | — |
| 2025 | 4 | Brock Purdy | QB | Shoulder / Toe | — |
| 2025 | 4 | Renardo Green | CB | Neck | Questionable |
| 2025 | 4 | Ricky Pearsall | WR | Knee | Questionable |
| 2025 | 4 | Jordan Watkins | WR | Calf | Out |
| 2025 | 4 | Connor Colby | G | Groin | Questionable |
| 2025 | 4 | Mykel Williams | DE | Wrist | — |
| 2025 | 4 | CJ West | DT | Thumb | Out |
| 2025 | 5 | Colton McKivitz | T | Calf | — |
| 2025 | 5 | Jauan Jennings | WR | Ankle / Rib | Out |
| 2025 | 5 | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 5 | Mac Jones | QB | Knee | — |
| 2025 | 5 | Brock Purdy | QB | Toe | Out |
| 2025 | 5 | Robert Beal Jr. | DE | Ankle | Out |
| 2025 | 5 | Dee Winters | LB | Knee | — |
| 2025 | 5 | Renardo Green | CB | Neck | — |
| 2025 | 5 | Ricky Pearsall | WR | Knee | Out |
| 2025 | 5 | Jordan Watkins | WR | Calf | Out |
| 2025 | 5 | Mykel Williams | DE | Wrist / Oblique | — |
| 2025 | 5 | CJ West | DT | Thumb | Questionable |
| 2025 | 6 | Thomas Morstead | P | Back | — |
| 2025 | 6 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 6 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 6 | Kendrick Bourne | WR | Rib | — |
| 2025 | 6 | Kevin Givens | DT | Pectoral | Out |
| 2025 | 6 | Jauan Jennings | WR | Ankle / Rib | Questionable |
| 2025 | 6 | Yetur Gross-Matos | DE | Knee / Hamstring | Out |
| 2025 | 6 | Mac Jones | QB | Knee / Oblique | Questionable |
| 2025 | 6 | Kalia Davis | DT | Hand | Questionable |
| 2025 | 6 | Brock Purdy | QB | Toe | Out |
| 2025 | 6 | Robert Beal Jr. | DE | Ankle | — |
| 2025 | 6 | Malik Mustapha | S | Knee | Questionable |
| 2025 | 6 | Ricky Pearsall | WR | Knee | Out |
| 2025 | 6 | Upton Stout | CB | Ankle | Questionable |
| 2025 | 6 | Jordan Watkins | WR | Calf | Out |
| 2025 | 6 | Mykel Williams | DE | Wrist / Oblique | — |
| 2025 | 6 | CJ West | DT | Thumb | — |
| 2025 | 6 | Alfred Collins | DT | Knee | Questionable |
| 2025 | 7 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 7 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 7 | George Kittle | TE | Hamstring | — |
| 2025 | 7 | Marquez Valdes-Scantling | WR | Calf | — |
| 2025 | 7 | Fred Warner | LB | Ankle | Out |
| 2025 | 7 | Kevin Givens | DT | Pectoral | Questionable |
| 2025 | 7 | Jauan Jennings | WR | Ankle / Rib | — |
| 2025 | 7 | Yetur Gross-Matos | DE | Knee / Hamstring | Out |
| 2025 | 7 | Mac Jones | QB | Knee / Oblique | — |
| 2025 | 7 | Kalia Davis | DT | Hand | — |
| 2025 | 7 | Brock Purdy | QB | Toe | Out |
| 2025 | 7 | Skyy Moore | WR | Ankle | — |
| 2025 | 7 | Renardo Green | CB | Neck | Questionable |
| 2025 | 7 | Dominick Puni | G | Knee | — |
| 2025 | 7 | Ricky Pearsall | WR | Knee | Out |
| 2025 | 7 | Upton Stout | CB | Shoulder | Questionable |
| 2025 | 7 | Jordan Watkins | WR | Calf | — |
| 2025 | 7 | Mykel Williams | DE | Thumb | — |
| 2025 | 7 | CJ West | DT | Thumb | — |
| 2025 | 8 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 8 | Jake Brendel | C | Hamstring | Out |
| 2025 | 8 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 8 | Luke Gifford | LB | Hamstring | Questionable |
| 2025 | 8 | Bryce Huff | DE | Hamstring | Out |
| 2025 | 8 | Jauan Jennings | WR | Ankle | — |
| 2025 | 8 | Yetur Gross-Matos | DE | Knee / Hamstring | Out |
| 2025 | 8 | Deommodore Lenoir | CB | Quadricep | Questionable |
| 2025 | 8 | Mac Jones | QB | Knee / Oblique | — |
| 2025 | 8 | Spencer Burford | T | Knee | Questionable |
| 2025 | 8 | Kalia Davis | DT | Hand | — |
| 2025 | 8 | Brock Purdy | QB | Toe | Out |
| 2025 | 8 | Renardo Green | CB | Toe | — |
| 2025 | 8 | Ricky Pearsall | WR | Knee | Out |
| 2025 | 8 | Upton Stout | CB | Ankle | — |
| 2025 | 8 | CJ West | DT | Thumb | — |
| 2025 | 9 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 9 | Jake Brendel | C | Hamstring | Out |
| 2025 | 9 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 9 | George Kittle | TE | Oblique | — |
| 2025 | 9 | Bryce Huff | DE | Hamstring | Out |
| 2025 | 9 | Jauan Jennings | WR | Ankle | — |
| 2025 | 9 | Jordan Elliott | DT | Ankle / Not injury related - personal matter | Questionable |
| 2025 | 9 | Ben Bartch | G | Ankle | Questionable |
| 2025 | 9 | Yetur Gross-Matos | DE | Knee / Hamstring | Out |
| 2025 | 9 | Mac Jones | QB | Knee / Knee | — |
| 2025 | 9 | Sam Okuayinonu | DE | Ankle | Questionable |
| 2025 | 9 | Spencer Burford | T | Knee | Questionable |
| 2025 | 9 | Kalia Davis | DT | Hand | — |
| 2025 | 9 | Brock Purdy | QB | Toe | Questionable |
| 2025 | 9 | Dee Winters | LB | Knee | Questionable |
| 2025 | 9 | Keion White | DE | Not injury related - other | — |
| 2025 | 9 | Ricky Pearsall | WR | Knee | Out |
| 2025 | 9 | Upton Stout | CB | Shoulder | — |
| 2025 | 9 | Alfred Collins | DT | Shoulder | — |
| 2025 | 10 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 10 | Jake Brendel | C | Hamstring | — |
| 2025 | 10 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 10 | Bryce Huff | DE | Hamstring | — |
| 2025 | 10 | Jauan Jennings | WR | Ankle / Shoulder | — |
| 2025 | 10 | Ben Bartch | G | Ankle | Questionable |
| 2025 | 10 | Mac Jones | QB | Knee / Knee | — |
| 2025 | 10 | Kalia Davis | DT | Ankle | Questionable |
| 2025 | 10 | Brock Purdy | QB | Toe | Questionable |
| 2025 | 10 | Darrell Luter Jr. | CB | Achilles | — |
| 2025 | 10 | Dee Winters | LB | Knee / Knee | Questionable |
| 2025 | 10 | Keion White | DE | Groin | Questionable |
| 2025 | 10 | Tatum Bethune | LB | Thigh | Questionable |
| 2025 | 10 | Ricky Pearsall | WR | Knee | Out |
| 2025 | 10 | Mykel Williams | DE | Knee | Out |
| 2025 | 10 | Alfred Collins | DT | Hip | Questionable |
| 2025 | 11 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 11 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 11 | Deommodore Lenoir | CB | Calf | Questionable |
| 2025 | 11 | Mac Jones | QB | Knee / Knee | — |
| 2025 | 11 | Brock Purdy | QB | Toe | — |
| 2025 | 11 | Dee Winters | LB | Knee / Knee | — |
| 2025 | 11 | Ricky Pearsall | WR | Knee | — |
| 2025 | 11 | Alfred Collins | DT | Hip | — |
| 2025 | 12 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 12 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 12 | Eddy Pineiro | K | Hamstring | Out |
| 2025 | 12 | Luke Gifford | LB | Hip / Neck | Questionable |
| 2025 | 12 | Curtis Robinson | LB | Elbow | — |
| 2025 | 12 | Brock Purdy | QB | Toe | — |
| 2025 | 12 | Robert Beal Jr. | DE | Concussion | Doubtful |
| 2025 | 12 | Dee Winters | LB | Knee / Knee | — |
| 2025 | 12 | Tatum Bethune | LB | Ankle | Out |
| 2025 | 12 | Ricky Pearsall | WR | Knee | — |
| 2025 | 13 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 13 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 13 | Eddy Pineiro | K | Hamstring | Out |
| 2025 | 13 | Luke Gifford | LB | Hip / Calf | — |
| 2025 | 13 | Sam Okuayinonu | DE | Ankle | Out |
| 2025 | 13 | Brock Purdy | QB | Toe | — |
| 2025 | 13 | Robert Beal Jr. | DE | Concussion | — |
| 2025 | 13 | Dominick Puni | G | Shoulder | — |
| 2025 | 13 | Tatum Bethune | LB | Ankle | Out |
| 2025 | 13 | Ricky Pearsall | WR | Knee | — |
| 2025 | 15 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 15 | Kyle Juszczyk | FB | Ribs | — |
| 2025 | 15 | Christian McCaffrey | RB | Illness | — |
| 2025 | 15 | Eddy Pineiro | K | Hamstring | — |
| 2025 | 15 | Kevin Givens | DT | Not injury related - personal matter | — |
| 2025 | 15 | Yetur Gross-Matos | DE | Hamstring | Out |
| 2025 | 15 | Sam Okuayinonu | DE | Ankle | Out |
| 2025 | 15 | Tatum Bethune | LB | Ankle | Out |
| 2025 | 15 | Nick Martin | LB | Concussion | Out |
| 2025 | 15 | Kurtis Rourke | QB | Knee | Out |
| 2025 | 16 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 16 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 16 | Jordan Elliott | DT | Knee | — |
| 2025 | 16 | Yetur Gross-Matos | DE | Hamstring | Questionable |
| 2025 | 16 | Sam Okuayinonu | DE | Ankle | — |
| 2025 | 16 | Spencer Burford | G | Knee / Ankle | — |
| 2025 | 16 | Dee Winters | LB | Wrist | — |
| 2025 | 16 | Renardo Green | CB | Neck | Out |
| 2025 | 16 | Tatum Bethune | LB | Ankle | — |
| 2025 | 16 | Ricky Pearsall | WR | Knee / Ankle | Out |
| 2025 | 16 | Nick Martin | LB | Concussion | — |
| 2025 | 16 | Kurtis Rourke | QB | Knee | Out |
| 2025 | 17 | Trent Williams | T | Not injury related - resting player | — |
| 2025 | 17 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 17 | George Kittle | TE | Ankle | Questionable |
| 2025 | 17 | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 17 | Sam Okuayinonu | DE | Ankle | — |
| 2025 | 17 | Renardo Green | CB | Neck | Out |
| 2025 | 17 | Tatum Bethune | LB | Ankle | — |
| 2025 | 17 | Ricky Pearsall | WR | Knee / Ankle | Questionable |
| 2025 | 17 | Kurtis Rourke | QB | Knee | Out |
| 2025 | 18 | Trent Williams | T | Hamstring | Questionable |
| 2025 | 18 | Kyle Juszczyk | FB | Hip | — |
| 2025 | 18 | Christian McCaffrey | RB | Back | — |
| 2025 | 18 | George Kittle | TE | Ankle | Questionable |
| 2025 | 18 | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 18 | Keion White | DE | Groin | Questionable |
| 2025 | 18 | Renardo Green | CB | Neck | — |
| 2025 | 18 | Ricky Pearsall | WR | Knee / Ankle | Questionable |
| 2025 | 18 | Upton Stout | CB | Concussion | Questionable |
| 2025 | 19 (WC) | Trent Williams | T | Hamstring | Questionable |
| 2025 | 19 (WC) | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2025 | 19 (WC) | George Kittle | TE | Ankle | — |
| 2025 | 19 (WC) | Luke Gifford | LB | Quadricep | Questionable |
| 2025 | 19 (WC) | Jordan Elliott | DT | Knee | — |
| 2025 | 19 (WC) | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 19 (WC) | Kalia Davis | DT | Knee | — |
| 2025 | 19 (WC) | Ji'Ayir Brown | S | Rib | — |
| 2025 | 19 (WC) | Dee Winters | LB | Ankle | Questionable |
| 2025 | 19 (WC) | Keion White | DE | Groin / Hamstring | Questionable |
| 2025 | 19 (WC) | Renardo Green | CB | Ankle | Questionable |
| 2025 | 19 (WC) | Jacob Cowing | WR | Hamstring | Questionable |
| 2025 | 19 (WC) | Ricky Pearsall | WR | Knee / Ankle | Questionable |
| 2025 | 20 (DIV) | Trent Williams | T | Hamstring | — |
| 2025 | 20 (DIV) | Fred Warner | LB | Ankle | Out |
| 2025 | 20 (DIV) | Luke Gifford | LB | Quadricep | Questionable |
| 2025 | 20 (DIV) | Yetur Gross-Matos | DE | Knee | — |
| 2025 | 20 (DIV) | Ji'Ayir Brown | S | Hamstring | Out |
| 2025 | 20 (DIV) | Dee Winters | LB | Ankle | Questionable |
| 2025 | 20 (DIV) | Keion White | DE | Groin / Hamstring | — |
| 2025 | 20 (DIV) | Dominick Puni | G | Ankle | — |
| 2025 | 20 (DIV) | Jacob Cowing | WR | Hamstring | Questionable |
| 2025 | 20 (DIV) | Ricky Pearsall | WR | Knee | Questionable |
| 2026 | 1 | Kyle Juszczyk | FB | Finger | — |
| 2026 | 1 | George Kittle | TE | Achilles | — |
| 2026 | 1 | Dre Greenlaw | LB | Achilles | — |
| 2026 | 1 | Luke Gifford | LB | Hamstring | — |
| 2026 | 1 | Nick Bosa | DE | Knee | — |
| 2026 | 1 | Renardo Green | CB | Hamstring | — |
| 2026 | 1 | Upton Stout | CB | Achilles | — |
| 2026 | 1 | Alfred Collins | DT | Knee | Out |
| 2026 | 1 | James Thompson Jr. | DT | Hamstring | Questionable |
| 2026 | 1 | Romello Height | DE | Ankle | — |
| 2026 | 1 | Gracen Halton | DT | Ankle | — |
| 2026 | 2 | Trent Williams | T | Not injury related - resting player | — |
| 2026 | 2 | Kyle Juszczyk | FB | Finger | — |
| 2026 | 2 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2026 | 2 | George Kittle | TE | Achilles | — |
| 2026 | 2 | Eddy Pineiro | K | Illness | Questionable |
| 2026 | 2 | Dre Greenlaw | LB | Not injury related - resting player / Achilles | — |
| 2026 | 2 | Nick Bosa | DE | Not injury related - resting player / Knee | — |
| 2026 | 2 | Khalid Kareem | DE | Shoulder | — |
| 2026 | 2 | Keion White | DE | Back | — |
| 2026 | 2 | Upton Stout | CB | Achilles | — |
| 2026 | 2 | De'Zhaun Stribling | WR | Ankle | Out |
| 2026 | 2 | Kaelon Black | RB | Groin | Questionable |
| 2026 | 3 | Trent Williams | T | Not injury related - resting player | — |
| 2026 | 3 | Mike Evans | WR | Hip | Questionable |
| 2026 | 3 | Demarcus Robinson | WR | Ankle | Out |
| 2026 | 3 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2026 | 3 | Dre Greenlaw | LB | Not injury related - resting player / Achilles | — |
| 2026 | 3 | Nick Bosa | DE | Knee / Calf | Out |
| 2026 | 3 | James Thompson Jr. | DT | Ankle | Out |
| 2026 | 3 | Romello Height | DE | Hand | Out |
| 2026 | 4 | Trent Williams | T | Not injury related - resting player / Neck | — |
| 2026 | 4 | Mike Evans | WR | Ribs | — |
| 2026 | 4 | Christian McCaffrey | RB | Not injury related - resting player | — |
| 2026 | 4 | KhaDarel Hodge | WR | Knee | — |
| 2026 | 4 | Dre Greenlaw | LB | Quadricep | — |
| 2026 | 4 | Nick Bosa | DE | Knee / Calf | — |
| 2026 | 4 | Keion White | DE | Hamstring | — |
| 2026 | 4 | Mykel Williams | DE | Knee | — |
| 2026 | 4 | James Thompson Jr. | DT | Ankle | — |
| 2026 | 4 | Romello Height | DE | Hand | — |
| No results found. | |||||
Season History
| 2025 | San Francisco 49ers | 12 | 5 | 0 | Lost Div | 437 | 371 | 66 | Shanahan | |
| 2024 | San Francisco 49ers | 6 | 11 | 0 | 4th of 4 | - | 389 | 436 | -47 | Shanahan |
| 2023 | San Francisco 49ers | 12 | 5 | 0 | 1st of 4 | Lost SB | 491 | 298 | 193 | Shanahan |
| 2022 | San Francisco 49ers | 13 | 4 | 0 | 1st of 4 | Lost Conf | 450 | 277 | 173 | Shanahan |
| 2021 | San Francisco 49ers | 10 | 7 | 0 | 3rd of 4 | Lost Conf | 427 | 365 | 62 | Shanahan |
| 2020 | San Francisco 49ers | 6 | 10 | 0 | 4th of 4 | - | 376 | 390 | -14 | Shanahan |
| 2019 | San Francisco 49ers | 13 | 3 | 0 | 1st of 4 | Lost SB | 479 | 310 | 169 | Shanahan |
| 2018 | San Francisco 49ers | 4 | 12 | 0 | 3rd of 4 | - | 342 | 435 | -93 | Shanahan |
| 2017 | San Francisco 49ers | 6 | 10 | 0 | 4th of 4 | - | 331 | 383 | -52 | Shanahan |
| 2016 | San Francisco 49ers | 2 | 14 | 0 | 4th of 4 | - | 309 | 480 | -171 | Kelly |
| 2015 | San Francisco 49ers | 5 | 11 | 0 | 4th of 4 | - | 238 | 387 | -149 | Tomsula |
| 2014 | San Francisco 49ers | 8 | 8 | 0 | 3rd of 4 | - | 306 | 340 | -34 | Harbaugh |
| 2013 | San Francisco 49ers | 12 | 4 | 0 | 2nd of 4 | Lost Conf | 406 | 272 | 134 | Harbaugh |
| 2012 | San Francisco 49ers | 11 | 4 | 1 | 1st of 4 | Lost SB | 397 | 273 | 124 | Harbaugh |
| 2011 | San Francisco 49ers | 13 | 3 | 0 | 1st of 4 | Lost Conf | 380 | 229 | 151 | Harbaugh |
| 2010 | San Francisco 49ers | 6 | 10 | 0 | 3rd of 4 | - | 305 | 346 | -41 | Singletary, Tomsula |
| 2009 | San Francisco 49ers | 8 | 8 | 0 | 2nd of 4 | - | 330 | 281 | 49 | Singletary |
| 2008 | San Francisco 49ers | 7 | 9 | 0 | 2nd of 4 | - | 339 | 381 | -42 | Singletary, Nolan |
| 2007 | San Francisco 49ers | 5 | 11 | 0 | 3rd of 4 | - | 219 | 364 | -145 | Nolan |
| 2006 | San Francisco 49ers | 7 | 9 | 0 | 3rd of 4 | - | 298 | 412 | -114 | Nolan |
| 2005 | San Francisco 49ers | 4 | 12 | 0 | 4th of 4 | - | 239 | 428 | -189 | Nolan |
| 2004 | San Francisco 49ers | 2 | 14 | 0 | 4th of 4 | - | 259 | 452 | -193 | Erickson |
| 2003 | San Francisco 49ers | 7 | 9 | 0 | 3rd of 4 | - | 384 | 337 | 47 | Erickson |
| 2002 | San Francisco 49ers | 10 | 6 | 0 | 1st of 4 | Lost Div | 367 | 351 | 16 | Mariucci |
| 2001 | San Francisco 49ers | 12 | 4 | 0 | 2nd of 5 | Lost WC | 409 | 282 | 127 | Mariucci |
| 2000 | San Francisco 49ers | 6 | 10 | 0 | 4th of 5 | - | 388 | 422 | -34 | Mariucci |
| 1999 | San Francisco 49ers | 4 | 12 | 0 | 4th of 5 | - | 295 | 453 | -158 | Mariucci |
| 1998 | San Francisco 49ers | 12 | 4 | 0 | 2nd of 5 | Lost Div | 479 | 328 | 151 | Mariucci |
| 1997 | San Francisco 49ers | 13 | 3 | 0 | 1st of 5 | Lost Conf | 375 | 265 | 110 | Mariucci |
| 1996 | San Francisco 49ers | 12 | 4 | 0 | 2nd of 5 | Lost Div | 398 | 257 | 141 | Seifert |
| 1995 | San Francisco 49ers | 11 | 5 | 0 | 1st of 5 | Lost Div | 457 | 258 | 199 | Seifert |
| 1994 | San Francisco 49ers | 13 | 3 | 0 | 1st of 4 | Won SB | 505 | 296 | 209 | Seifert |
| 1993 | San Francisco 49ers | 10 | 6 | 0 | 1st of 4 | Lost Conf | 473 | 295 | 178 | Seifert |
| 1992 | San Francisco 49ers | 14 | 2 | 0 | 1st of 4 | Lost Conf | 431 | 236 | 195 | Seifert |
| 1991 | San Francisco 49ers | 10 | 6 | 0 | 3rd of 4 | - | 393 | 239 | 154 | Seifert |
| 1990 | San Francisco 49ers | 14 | 2 | 0 | 1st of 4 | Lost Conf | 353 | 239 | 114 | Seifert |
| 1989 | San Francisco 49ers | 14 | 2 | 0 | 1st of 4 | Won SB | 442 | 253 | 189 | Seifert |
| 1988 | San Francisco 49ers | 10 | 6 | 0 | 1st of 4 | Won SB | 369 | 294 | 75 | Walsh |
| 1987 | San Francisco 49ers | 13 | 2 | 0 | 1st of 4 | Lost Div | 459 | 253 | 206 | Walsh |
| 1986 | San Francisco 49ers | 10 | 5 | 1 | 1st of 4 | Lost Div | 374 | 247 | 127 | Walsh |
| 1985 | San Francisco 49ers | 10 | 6 | 0 | 2nd of 4 | Lost WC | 411 | 263 | 148 | Walsh |
| 1984 | San Francisco 49ers | 15 | 1 | 0 | 1st of 4 | Won SB | 475 | 227 | 248 | Walsh |
| 1983 | San Francisco 49ers | 10 | 6 | 0 | 1st of 4 | Lost Conf | 432 | 293 | 139 | Walsh |
| 1982 | San Francisco 49ers | 3 | 6 | 0 | 3rd of 4 | - | 209 | 206 | 3 | Walsh |
| 1981 | San Francisco 49ers | 13 | 3 | 0 | 1st of 4 | Won SB | 357 | 250 | 107 | Walsh |
| 1980 | San Francisco 49ers | 6 | 10 | 0 | 3rd of 4 | - | 320 | 415 | -95 | Walsh |
| 1979 | San Francisco 49ers | 2 | 14 | 0 | 4th of 4 | - | 308 | 416 | -108 | Walsh |
| 1978 | San Francisco 49ers | 2 | 14 | 0 | 4th of 4 | - | 219 | 350 | -131 | O', Connor, McCulley |
| 1977 | San Francisco 49ers | 5 | 9 | 0 | 3rd of 4 | - | 220 | 260 | -40 | Meyer |
| 1976 | San Francisco 49ers | 8 | 6 | 0 | 2nd of 5 | - | 270 | 190 | 80 | Clark |
| 1975 | San Francisco 49ers | 5 | 9 | 0 | 2nd of 4 | - | 255 | 286 | -31 | Nolan |
| 1974 | San Francisco 49ers | 6 | 8 | 0 | 2nd of 4 | - | 226 | 236 | -10 | Nolan |
| 1973 | San Francisco 49ers | 5 | 9 | 0 | 3rd of 4 | - | 262 | 319 | -57 | Nolan |
| 1972 | San Francisco 49ers | 8 | 5 | 1 | 1st of 4 | Lost Div | 353 | 249 | 104 | Nolan |
| 1971 | San Francisco 49ers | 9 | 5 | 0 | 1st of 4 | Lost Conf | 300 | 216 | 84 | Nolan |
| 1970 | San Francisco 49ers | 10 | 3 | 1 | 1st of 4 | Lost Conf | 352 | 267 | 85 | Nolan |
| 1969 | San Francisco 49ers | 4 | 8 | 2 | 4th of 4 | - | 277 | 319 | -42 | Nolan |
| 1968 | San Francisco 49ers | 7 | 6 | 1 | 3rd of 4 | - | 303 | 310 | -7 | Nolan |
| 1967 | San Francisco 49ers | 7 | 7 | 0 | 3rd of 4 | - | 273 | 337 | -64 | Christiansen |
| 1966 | San Francisco 49ers | 6 | 6 | 2 | 4th of 7 | - | 320 | 325 | -5 | Christiansen |
| 1965 | San Francisco 49ers | 7 | 6 | 1 | 4th of 7 | - | 421 | 402 | 19 | Christiansen |
| 1964 | San Francisco 49ers | 4 | 10 | 0 | 7th of 7 | - | 236 | 330 | -94 | Christiansen |
| 1963 | San Francisco 49ers | 2 | 12 | 0 | 7th of 7 | - | 198 | 391 | -193 | Christiansen, Hickey |
| 1962 | San Francisco 49ers | 6 | 8 | 0 | 5th of 7 | - | 282 | 331 | -49 | Hickey |
| 1961 | San Francisco 49ers | 7 | 6 | 1 | 5th of 7 | - | 346 | 272 | 74 | Hickey |
| 1960 | San Francisco 49ers | 7 | 5 | 0 | 2nd of 7 | - | 208 | 205 | 3 | Hickey |
| 1959 | San Francisco 49ers | 7 | 5 | 0 | 3rd of 6 | - | 255 | 237 | 18 | Hickey |
| 1958 | San Francisco 49ers | 6 | 6 | 0 | 4th of 6 | - | 257 | 324 | -67 | Albert |
| 1957 | San Francisco 49ers | 8 | 4 | 0 | 1st of 6 | Lost Div | 260 | 264 | -4 | Albert |
| 1956 | San Francisco 49ers | 5 | 6 | 1 | 3rd of 6 | - | 233 | 284 | -51 | Albert |
| 1955 | San Francisco 49ers | 4 | 8 | 0 | 5th of 6 | - | 216 | 298 | -82 | Strader |
| 1954 | San Francisco 49ers | 7 | 4 | 1 | 3rd of 6 | - | 313 | 251 | 62 | Shaw |
| 1953 | San Francisco 49ers | 9 | 3 | 0 | 2nd of 6 | - | 372 | 237 | 135 | Shaw |
| 1952 | San Francisco 49ers | 7 | 5 | 0 | 3rd of 6 | - | 285 | 221 | 64 | Shaw |
| 1951 | San Francisco 49ers | 7 | 4 | 1 | 2nd of 6 | - | 255 | 205 | 50 | Shaw |
| 1950 | San Francisco 49ers | 3 | 9 | 0 | 5th of 7 | - | 213 | 300 | -87 | Shaw |
| 1949 | San Francisco 49ers | 9 | 3 | 0 | 2nd of 7 | Lost Champ | 416 | 227 | 189 | Shaw |
| 1948 | San Francisco 49ers | 12 | 2 | 0 | 2nd of 4 | - | 495 | 248 | 247 | Shaw |
| 1947 | San Francisco 49ers | 8 | 4 | 2 | 2nd of 4 | - | 327 | 264 | 63 | Shaw |
| 1946 | San Francisco 49ers | 9 | 5 | 0 | 2nd of 4 | - | 307 | 189 | 118 | Shaw |
| No results found. | ||||||||||
| Total | 0 | 0 | 0 | 0 | 0 | 0 | ||||
Draft History
| 2026 | 2 | 33 | De'Zhaun Stribling | WR |
| 2026 | 3 | 70 | Romello Height | DE |
| 2026 | 3 | 90 | Kaelon Black | RB |
| 2026 | 4 | 107 | Gracen Halton | DT |
| 2026 | 4 | 127 | Carver Willis | OL |
| 2026 | 4 | 139 | Ephesians Prysock | CB |
| 2026 | 5 | 154 | Jaden Dugger | OLB |
| 2026 | 5 | 179 | Enrique Cruz | OL |
| 2025 | 1 | 11 | Mykel Williams | DL |
| 2025 | 2 | 43 | Alfred Collins | DT |
| 2025 | 3 | 75 | Nick Martin | LB |
| 2025 | 3 | 100 | Upton Stout | CB |
| 2025 | 4 | 113 | CJ West | DT |
| 2025 | 4 | 138 | Jordan Watkins | WR |
| 2025 | 5 | 147 | Jordan James | RB |
| 2025 | 5 | 160 | Marques Sigle | SAF |
| 2025 | 7 | 227 | Kurtis Rourke | QB |
| 2025 | 7 | 249 | Connor Colby | OL |
| 2025 | 7 | 252 | Junior Bergen | WR |
| 2024 | 1 | 31 | Ricky Pearsall | WR |
| 2024 | 2 | 64 | Renardo Green | DB |
| 2024 | 3 | 86 | Dominick Puni | OL |
| 2024 | 4 | 124 | Malik Mustapha | DB |
| 2024 | 4 | 129 | Isaac Guerendo | RB |
| 2024 | 4 | 135 | Jacob Cowing | WR |
| 2024 | 6 | 215 | Jarrett Kingston | OL |
| 2024 | 7 | 251 | Tatum Bethune | LB |
| 2023 | 3 | 87 | Ji'Ayir Brown | S |
| 2023 | 3 | 99 | Jake Moody | K |
| 2023 | 3 | 101 | Cameron Latu | TE |
| 2023 | 5 | 155 | Darrell Luter | CB |
| 2023 | 5 | 173 | Robert Beal | OLB |
| 2023 | 6 | 216 | Dee Winters | LB |
| 2023 | 7 | 247 | Brayden Willis | TE |
| 2023 | 7 | 253 | Ronnie Bell | WR |
| 2023 | 7 | 255 | Jalen Graham | S |
| 2022 | 2 | 61 | Drake Jackson | OLB |
| 2022 | 3 | 93 | Tyrion Davis-Price↗ | RB |
| 2022 | 3 | 105 | Danny Gray | WR |
| 2022 | 4 | 134 | Spencer Burford | OL |
| 2022 | 5 | 172 | Samuel Womack | CB |
| 2022 | 6 | 187 | Nick Zakelj | OL |
| 2022 | 6 | 220 | Kalia Davis | DT |
| 2022 | 6 | 221 | Tariq Castro-Fields | CB |
| 2022 | 7 | 262 | Brock Purdy | QB |
| 2021 | 1 | 3 | Trey Lance | QB |
| 2021 | 2 | 48 | Aaron Banks | OL |
| 2021 | 3 | 88 | Trey Sermon | RB |
| 2021 | 3 | 102 | Ambry Thomas | DB |
| 2021 | 5 | 155 | Jaylon Moore | T |
| 2021 | 5 | 172 | Deommodore Lenoir | CB |
| 2021 | 5 | 180 | Talanoa Hufanga | S |
| 2021 | 6 | 194 | Elijah Mitchell↗ | RB |
| 2020 | 1 | 14 | Javon Kinlaw | DT |
| 2020 | 1 | 25 | Brandon Aiyuk | WR |
| 2020 | 5 | 153 | Colton McKivitz | T |
| 2020 | 6 | 190 | Charlie Woerner | TE |
| 2020 | 7 | 217 | Jauan Jennings | WR |
| 2019 | 1 | 2 | Nick Bosa | DE |
| 2019 | 2 | 36 | Deebo Samuel↗ | WR |
| 2019 | 3 | 67 | Jalen Hurd↗ | WR |
| 2019 | 4 | 110 | Mitch Wishnowsky | P |
| 2019 | 5 | 148 | Dre Greenlaw | LB |
| 2019 | 6 | 176 | Kaden Smith↗ | TE |
| 2019 | 6 | 183 | Justin Skule | T |
| 2019 | 6 | 198 | Tim Harris↗ | CB |
| 2018 | 1 | 9 | Mike McGlinchey | T |
| 2018 | 2 | 44 | Dante Pettis↗ | WR |
| 2018 | 3 | 70 | Fred Warner | OLB |
| 2018 | 3 | 95 | Tarvarius Moore↗ | S |
| 2018 | 4 | 128 | Kentavius Street | DT |
| 2018 | 5 | 142 | D.J. Reed | CB |
| 2018 | 6 | 184 | Marcell Harris↗ | S |
| 2018 | 7 | 223 | Jullian Taylor↗ | DT |
| 2018 | 7 | 240 | Richie James↗ | WR |
| 2017 | 1 | 3 | Solomon Thomas | DE |
| 2017 | 1 | 31 | Reuben Foster↗ | LB |
| 2017 | 3 | 66 | Ahkello Witherspoon | CB |
| 2017 | 3 | 104 | C.J. Beathard↗ | QB |
| 2017 | 4 | 121 | Joe Williams↗ | RB |
| 2017 | 5 | 146 | George Kittle | TE |
| 2017 | 5 | 177 | Trent Taylor↗ | WR |
| 2017 | 6 | 198 | D.J. Jones | DT |
| 2017 | 6 | 202 | Pita Taumoepenu↗ | OLB |
| 2017 | 7 | 229 | Adrian Colbert↗ | DB |
| 2016 | 1 | 7 | DeForest Buckner | DE |
| 2016 | 1 | 28 | Joshua Garnett↗ | G |
| 2016 | 3 | 68 | Will Redmond↗ | CB |
| 2016 | 4 | 133 | Rashard Robinson↗ | CB |
| 2016 | 5 | 142 | Ronald Blair↗ | DE |
| 2016 | 5 | 145 | John Theus↗ | T |
| 2016 | 5 | 174 | Fahn Cooper↗ | T |
| 2016 | 6 | 207 | Jeff Driskel↗ | QB |
| 2016 | 6 | 211 | Kelvin Taylor↗ | RB |
| 2016 | 6 | 213 | Aaron Burbridge↗ | WR |
| 2016 | 7 | 249 | Prince Charles Iworah↗ | CB |
| 2015 | 1 | 17 | Arik Armstead | DT |
| 2015 | 2 | 46 | Jaquiski Tartt↗ | S |
| 2015 | 3 | 79 | Eli Harold↗ | OLB |
| 2015 | 4 | 117 | Blake Bell↗ | TE |
| 2015 | 4 | 126 | Mike Davis↗ | RB |
| 2015 | 4 | 132 | DeAndre Smelter↗ | WR |
| 2015 | 5 | 165 | Bradley Pinion | P |
| 2015 | 6 | 190 | Ian Silberman↗ | G |
| 2015 | 7 | 244 | Trent Brown | G |
| 2015 | 7 | 254 | Rory Anderson↗ | TE |
| 2014 | 1 | 30 | Jimmie Ward↗ | DB |
| 2014 | 2 | 57 | Carlos Hyde↗ | RB |
| 2014 | 3 | 70 | Marcus Martin↗ | C |
| 2014 | 3 | 77 | Chris Borland↗ | LB |
| 2014 | 3 | 100 | Brandon Thomas↗ | OL |
| 2014 | 4 | 106 | Bruce Ellington↗ | WR |
| 2014 | 4 | 129 | Dontae Johnson↗ | DB |
| 2014 | 5 | 150 | Aaron Lynch↗ | DE |
| 2014 | 5 | 170 | Keith Reaser↗ | DB |
| 2014 | 6 | 180 | Kenneth Acker↗ | DB |
| 2014 | 7 | 243 | Kaleb Ramsey↗ | DE |
| 2014 | 7 | 245 | Trey Millard↗ | FB |
| 2013 | 1 | 18 | Eric Reid↗ | DB |
| 2013 | 2 | 40 | Tank Carradine↗ | DE |
| 2013 | 2 | 55 | Vance McDonald↗ | TE |
| 2013 | 3 | 88 | Corey Lemonier↗ | DE |
| 2013 | 4 | 128 | Quinton Patton↗ | WR |
| 2013 | 4 | 131 | Marcus Lattimore↗ | RB |
| 2013 | 5 | 157 | Quinton Dial↗ | DE |
| 2013 | 6 | 180 | Nick Moody↗ | LB |
| 2013 | 7 | 237 | B.J. Daniels↗ | QB |
| 2013 | 7 | 246 | Carter Bykowski↗ | OL |
| 2013 | 7 | 252 | Marcus Cooper↗ | DB |
| 2012 | 1 | 30 | A.J. Jenkins↗ | WR |
| 2012 | 2 | 61 | LaMichael James↗ | RB |
| 2012 | 4 | 117 | Joe Looney↗ | G |
| 2012 | 5 | 165 | Darius Fleming↗ | LB |
| 2012 | 6 | 180 | Trent Robinson↗ | DB |
| 2012 | 6 | 199 | Jason Slowey↗ | OL |
| 2012 | 7 | 237 | Cam Johnson↗ | DE |
| 2011 | 1 | 7 | Aldon Smith↗ | DE |
| 2011 | 2 | 36 | Colin Kaepernick↗ | QB |
| 2011 | 3 | 80 | Chris Culliver↗ | DB |
| 2011 | 4 | 115 | Kendall Hunter↗ | RB |
| 2011 | 5 | 163 | Daniel Kilgore↗ | G |
| 2011 | 6 | 182 | Ronald Johnson↗ | WR |
| 2011 | 6 | 190 | Colin Jones↗ | DB |
| 2011 | 7 | 211 | Bruce Miller↗ | DE |
| 2011 | 7 | 239 | Michael Person↗ | G |
| 2011 | 7 | 250 | Curtis Holcomb↗ | DB |
| 2010 | 1 | 11 | Anthony Davis↗ | T |
| 2010 | 1 | 17 | Mike Iupati↗ | G |
| 2010 | 2 | 49 | Taylor Mays↗ | DB |
| 2010 | 3 | 91 | NaVorro Bowman↗ | LB |
| 2010 | 6 | 173 | Anthony Dixon↗ | RB |
| 2010 | 6 | 182 | Nate Byham↗ | TE |
| 2010 | 6 | 206 | Kyle Williams↗ | WR |
| 2010 | 7 | 224 | Phillip Adams↗ | DB |
| 2009 | 1 | 10 | Michael Crabtree↗ | WR |
| 2009 | 3 | 74 | Glen Coffee↗ | RB |
| 2009 | 5 | 146 | Scott McKillop↗ | LB |
| 2009 | 5 | 171 | Nate Davis↗ | QB |
| 2009 | 6 | 184 | Bear Pascoe↗ | TE |
| 2009 | 7 | 219 | Curtis Taylor↗ | DB |
| 2009 | 7 | 244 | Ricky Jean-Francois↗ | DT |
| 2008 | 1 | 29 | Kentwan Balmer↗ | DT |
| 2008 | 2 | 39 | Chilo Rachal↗ | G |
| 2008 | 3 | 75 | Reggie Smith↗ | DB |
| 2008 | 4 | 107 | Cody Wallace↗ | C |
| 2008 | 6 | 174 | Josh Morgan↗ | WR |
| 2008 | 7 | 214 | Larry Grant↗ | LB |
| 2007 | 1 | 11 | Patrick Willis HOF↗ | LB |
| 2007 | 1 | 28 | Joe Staley↗ | T |
| 2007 | 3 | 76 | Jason Hill↗ | WR |
| 2007 | 3 | 97 | Ray McDonald↗ | DE |
| 2007 | 4 | 104 | Jay Moore | DE |
| 2007 | 4 | 126 | Dashon Goldson↗ | DB |
| 2007 | 4 | 135 | Joe Cohen↗ | DT |
| 2007 | 5 | 147 | Tarell Brown↗ | DB |
| 2007 | 6 | 186 | Thomas Clayton | RB |
| 2006 | 1 | 6 | Vernon Davis↗ | TE |
| 2006 | 1 | 22 | Manny Lawson↗ | DE |
| 2006 | 3 | 84 | Brandon Williams↗ | WR |
| 2006 | 4 | 100 | Michael Robinson↗ | WR |
| 2006 | 5 | 140 | Parys Haralson↗ | DE |
| 2006 | 6 | 175 | Delanie Walker↗ | WR |
| 2006 | 6 | 192 | Marcus Hudson↗ | DB |
| 2006 | 6 | 197 | Melvin Oliver↗ | DE |
| 2006 | 7 | 254 | Vickiel Vaughn | DB |
| 2005 | 1 | 1 | Alex Smith↗ | QB |
| 2005 | 2 | 33 | David Baas↗ | G |
| 2005 | 3 | 65 | Frank Gore↗ | RB |
| 2005 | 3 | 94 | Adam Snyder↗ | T |
| 2005 | 5 | 137 | Ronald Fields↗ | DT |
| 2005 | 5 | 174 | Rasheed Marshall↗ | WR |
| 2005 | 6 | 205 | Derrick Johnson↗ | DB |
| 2005 | 7 | 215 | Daven Holly↗ | DB |
| 2005 | 7 | 223 | Marcus Maxwell↗ | WR |
| 2005 | 7 | 248 | Patrick Estes↗ | TE |
| 2005 | 7 | 249 | Billy Bajema↗ | TE |
| 2004 | 1 | 31 | Rashaun Woods↗ | WR |
| 2004 | 2 | 46 | Justin Smiley↗ | G |
| 2004 | 2 | 58 | Shawntae Spencer↗ | DB |
| 2004 | 3 | 77 | Derrick Hamilton↗ | WR |
| 2004 | 4 | 104 | Isaac Sopoaga↗ | DT |
| 2004 | 4 | 127 | Richard Seigler↗ | LB |
| 2004 | 6 | 188 | Andy Lee↗ | P |
| 2004 | 6 | 198 | Keith Lewis↗ | DB |
| 2004 | 7 | 217 | Cody Pickett↗ | QB |
| 2004 | 7 | 226 | Christian Ferrara | DT |
| 2003 | 1 | 26 | Kwame Harris↗ | T |
| 2003 | 2 | 57 | Anthony Adams↗ | DT |
| 2003 | 3 | 89 | Andrew Williams↗ | DE |
| 2003 | 4 | 124 | Brandon Lloyd↗ | WR |
| 2003 | 5 | 161 | Aaron Walker↗ | TE |
| 2003 | 6 | 197 | Arnaz Battle↗ | WR |
| 2003 | 7 | 241 | Ken Dorsey↗ | QB |
| 2002 | 1 | 27 | Mike Rumph↗ | DB |
| 2002 | 3 | 69 | Saleem Rasheed↗ | LB |
| 2002 | 4 | 102 | Jeff Chandler↗ | K |
| 2002 | 4 | 127 | Kevin Curtis | DB |
| 2002 | 5 | 163 | Brandon Doman | QB |
| 2002 | 5 | 172 | Josh Shaw↗ | DT |
| 2002 | 6 | 201 | Mark Anelli↗ | TE |
| 2002 | 7 | 239 | Eric Heitmann↗ | G |
| 2002 | 7 | 248 | Kyle Kosier↗ | G |
| 2002 | 7 | 256 | Teddy Gaines | DB |
| 2001 | 1 | 7 | Andre Carter↗ | DE |
| 2001 | 2 | 47 | Jamie Winborn↗ | LB |
| 2001 | 3 | 80 | Kevan Barlow↗ | RB |
| 2001 | 6 | 169 | Cedrick Wilson↗ | WR |
| 2001 | 6 | 179 | Rashad Holman↗ | DB |
| 2001 | 6 | 191 | Menson Holloway | DE |
| 2001 | 7 | 209 | Alex Lincoln | LB |
| 2001 | 7 | 224 | Eric Johnson↗ | TE |
| 2000 | 1 | 16 | Julian Peterson↗ | LB |
| 2000 | 1 | 24 | Ahmed Plummer↗ | DB |
| 2000 | 2 | 35 | John Engelberger↗ | DE |
| 2000 | 2 | 48 | Jason Webster↗ | DB |
| 2000 | 3 | 65 | Giovanni Carmazzi | QB |
| 2000 | 3 | 86 | Jeff Ulbrich↗ | LB |
| 2000 | 4 | 108 | John Keith↗ | DB |
| 2000 | 5 | 132 | Paul Smith↗ | RB |
| 2000 | 5 | 150 | John Milem↗ | DE |
| 2000 | 7 | 212 | Tim Rattay↗ | QB |
| 2000 | 7 | 230 | Brian Jennings↗ | TE |
| 1999 | 1 | 24 | Reggie McGrew↗ | DT |
| 1999 | 3 | 89 | Chike Okeafor↗ | DE |
| 1999 | 4 | 99 | Anthony Parker↗ | DB |
| 1999 | 4 | 110 | Pierson Prioleau↗ | DB |
| 1999 | 5 | 157 | Terry Jackson↗ | FB |
| 1999 | 5 | 161 | Tyrone Hopson↗ | G |
| 1999 | 6 | 171 | Tai Streets↗ | WR |
| 1999 | 7 | 234 | Kory Minor↗ | LB |
| 1998 | 1 | 28 | R.W. McQuarters↗ | DB |
| 1998 | 2 | 58 | Jeremy Newberry↗ | C |
| 1998 | 3 | 89 | Chris Ruhman↗ | T |
| 1998 | 4 | 119 | Lance Schulters↗ | DB |
| 1998 | 5 | 151 | Phil Ostrowski↗ | G |
| 1998 | 6 | 180 | Fred Beasley↗ | FB |
| 1998 | 7 | 215 | Ryan Thelwell↗ | WR |
| 1997 | 1 | 26 | Jim Druckenmiller↗ | QB |
| 1997 | 2 | 55 | Marc Edwards↗ | FB |
| 1997 | 3 | 77 | Greg Clark↗ | TE |
| 1996 | 2 | 46 | Israel Ifeanyi↗ | DE |
| 1996 | 3 | 89 | Terrell Owens HOF↗ | WR |
| 1996 | 4 | 128 | Daryl Price↗ | DE |
| 1996 | 5 | 160 | Iheanyi Uwaezuoke↗ | WR |
| 1996 | 6 | 198 | Stephen Pitts | RB |
| 1996 | 7 | 239 | Sean Manuel↗ | TE |
| 1996 | 7 | 254 | Sam Manuel | LB |
| 1995 | 1 | 10 | J.J. Stokes↗ | WR |
| 1995 | 4 | 127 | Tim Hanshaw↗ | G |
| 1995 | 6 | 201 | Antonio Armstrong↗ | LB |
| 1995 | 7 | 238 | Herbert Coleman | DE |
| 1994 | 1 | 7 | Bryant Young HOF↗ | DT |
| 1994 | 1 | 28 | William Floyd↗ | FB |
| 1994 | 2 | 53 | Kevin Mitchell↗ | LB |
| 1994 | 2 | 62 | Tyronne Drakeford↗ | DB |
| 1994 | 3 | 85 | Doug Brien↗ | K |
| 1994 | 3 | 87 | Cory Fleming↗ | WR |
| 1994 | 5 | 153 | Tony Peterson↗ | LB |
| 1994 | 6 | 182 | Lee Woodall↗ | LB |
| 1993 | 1 | 26 | Dana Stubblefield↗ | DT |
| 1993 | 1 | 27 | Todd Kelly↗ | LB |
| 1993 | 2 | 48 | Adrian Hardy↗ | DB |
| 1993 | 5 | 116 | Artie Smith↗ | DE |
| 1993 | 6 | 166 | Chris Dalman↗ | C |
| 1993 | 7 | 194 | Troy Wilson↗ | DE |
| 1993 | 8 | 219 | Elvis Grbac↗ | QB |
| 1992 | 1 | 18 | Dana Hall↗ | DB |
| 1992 | 2 | 45 | Amp Lee↗ | RB |
| 1992 | 3 | 76 | Brian Bollinger↗ | G |
| 1992 | 4 | 89 | Mark Thomas↗ | DE |
| 1992 | 6 | 151 | Damien Russell↗ | DB |
| 1992 | 9 | 242 | Darian Hagan | QB |
| 1992 | 10 | 269 | Corey Mayfield↗ | DT |
| 1992 | 11 | 300 | Tom Covington | TE |
| 1992 | 12 | 327 | Matt LaBounty↗ | DE |
| 1991 | 1 | 25 | Ted Washington↗ | NT |
| 1991 | 2 | 45 | Ricky Watters↗ | RB |
| 1991 | 2 | 53 | John Johnson↗ | LB |
| 1991 | 4 | 95 | Mitch Donahue↗ | LB |
| 1991 | 5 | 122 | Merton Hanks↗ | DB |
| 1991 | 5 | 137 | Harry Boatswain↗ | G |
| 1991 | 6 | 165 | Scott Bowles | T |
| 1991 | 7 | 193 | Sheldon Canley↗ | RB |
| 1991 | 8 | 221 | Tony Hargain↗ | WR |
| 1991 | 9 | 248 | Louis Riddick↗ | DB |
| 1991 | 10 | 276 | Byron Holdbrooks | DT |
| 1991 | 11 | 304 | Bobby Slaughter | WR |
| 1991 | 12 | 332 | Cliff Confer | DE |
| 1990 | 1 | 25 | Dexter Carter↗ | RB |
| 1990 | 2 | 47 | Dennis Brown↗ | DE |
| 1990 | 2 | 53 | Eric Davis↗ | DB |
| 1990 | 3 | 68 | Ron Lewis↗ | WR |
| 1990 | 4 | 92 | Dean Caliguire↗ | G |
| 1990 | 6 | 165 | Frank Pollack↗ | T |
| 1990 | 8 | 220 | Dwight Pickens | WR |
| 1990 | 9 | 248 | Odell Haggins↗ | NT |
| 1990 | 10 | 276 | Martin Harrison↗ | DE |
| 1990 | 11 | 289 | Anthony Shelton↗ | DB |
| 1989 | 1 | 28 | Keith DeLong↗ | LB |
| 1989 | 2 | 56 | Wesley Walls↗ | TE |
| 1989 | 3 | 84 | Keith Henderson↗ | RB |
| 1989 | 4 | 112 | Michael Barber↗ | WR |
| 1989 | 5 | 122 | Johnnie Jackson↗ | DB |
| 1989 | 6 | 167 | Steve Hendrickson↗ | LB |
| 1989 | 9 | 251 | Rudy Harmon | LB |
| 1989 | 10 | 279 | Andy Sinclair | C |
| 1989 | 11 | 289 | Jim Bell | RB |
| 1989 | 11 | 307 | Norm McGee | WR |
| 1989 | 12 | 319 | Antonio Goss↗ | LB |
| 1988 | 2 | 33 | Danny Stubbs↗ | DE |
| 1988 | 2 | 39 | Pierce Holt↗ | DE |
| 1988 | 3 | 80 | Bill Romanowski↗ | LB |
| 1988 | 4 | 102 | Barry Helton↗ | P |
| 1988 | 7 | 191 | Kevin Bryant | LB |
| 1988 | 8 | 219 | Larry Clarkson | T |
| 1988 | 9 | 247 | Brian Bonner↗ | LB |
| 1988 | 10 | 275 | Tim Foley | K |
| 1988 | 11 | 303 | Chet Brooks↗ | DB |
| 1988 | 12 | 331 | George Jr. Mira | LB |
| 1987 | 1 | 22 | Harris Barton↗ | T |
| 1987 | 1 | 25 | Terrence Flagler↗ | RB |
| 1987 | 2 | 37 | Jeff Bregel↗ | G |
| 1987 | 5 | 134 | Paul Jokisch | WR |
| 1987 | 6 | 162 | Bob White | LB |
| 1987 | 7 | 189 | Steve DeLine↗ | K |
| 1987 | 8 | 217 | David Grayson↗ | LB |
| 1987 | 9 | 245 | Jonathan Shelley↗ | DB |
| 1987 | 10 | 275 | John Paye | QB |
| 1987 | 11 | 301 | Calvin Nicholas↗ | WR |
| 1986 | 2 | 39 | Larry Roberts↗ | DE |
| 1986 | 3 | 56 | Tom Rathman↗ | RB |
| 1986 | 3 | 64 | Tim McKyer↗ | DB |
| 1986 | 3 | 76 | John Taylor↗ | WR |
| 1986 | 4 | 96 | Charles Haley HOF↗ | DE |
| 1986 | 4 | 101 | Steve Wallace↗ | T |
| 1986 | 4 | 102 | Kevin Fagan↗ | DE |
| 1986 | 5 | 131 | Pat Miller↗ | LB |
| 1986 | 6 | 162 | Don Griffin↗ | DB |
| 1986 | 8 | 203 | Jim Popp | TE |
| 1986 | 9 | 240 | Tony Cherry↗ | RB |
| 1986 | 10 | 267 | Elliston Stinson | WR |
| 1986 | 10 | 270 | Harold Hallman | LB |
| 1985 | 1 | 16 | Jerry Rice HOF↗ | WR |
| 1985 | 3 | 75 | Ricky Moore↗ | RB |
| 1985 | 5 | 140 | Bruce Collie↗ | G |
| 1985 | 6 | 168 | Scott Barry | QB |
| 1985 | 11 | 308 | David Wood | DE |
| 1985 | 12 | 336 | Donald Chumley | DT |
| 1984 | 1 | 24 | Todd Shell↗ | LB |
| 1984 | 2 | 56 | John Frank↗ | TE |
| 1984 | 3 | 73 | Guy McIntyre↗ | G |
| 1984 | 5 | 121 | Michael Carter↗ | NT |
| 1984 | 5 | 139 | Jeff Fuller↗ | DB |
| 1984 | 9 | 239 | Lee Miller | DB |
| 1984 | 9 | 248 | Derrick Harmon↗ | RB |
| 1984 | 10 | 275 | Dave Moritz | WR |
| 1984 | 11 | 307 | Kirk Pendleton | WR |
| 1983 | 2 | 49 | Roger Craig HOF↗ | RB |
| 1983 | 3 | 59 | Blanchard Montgomery↗ | LB |
| 1983 | 4 | 90 | Tom Holmoe↗ | DB |
| 1983 | 5 | 117 | Riki Ellison↗ | LB |
| 1983 | 7 | 175 | Gary Moten↗ | LB |
| 1983 | 9 | 229 | Mike Mularkey↗ | TE |
| 1983 | 10 | 259 | Jeff Merrell | DT |
| 1983 | 11 | 289 | Jesse Sapolu↗ | C |
| 1982 | 2 | 29 | Bubba Paris↗ | T |
| 1982 | 5 | 139 | Newton Williams↗ | RB |
| 1982 | 6 | 151 | Vince Williams↗ | RB |
| 1982 | 7 | 195 | Ron Ferrari↗ | LB |
| 1982 | 9 | 251 | Bryan Clark↗ | QB |
| 1982 | 10 | 269 | Dana McLemore↗ | DB |
| 1982 | 10 | 279 | Tim Barbian | DT |
| 1982 | 11 | 306 | Gary Gibson | LB |
| 1982 | 12 | 334 | Tim Washington↗ | DB |
| 1981 | 1 | 8 | Ronnie Lott HOF↗ | DB |
| 1981 | 2 | 36 | John Harty↗ | NT |
| 1981 | 2 | 40 | Eric Wright↗ | DB |
| 1981 | 3 | 65 | Carlton Williamson↗ | DB |
| 1981 | 5 | 121 | Lynn Thomas↗ | DB |
| 1981 | 5 | 122 | Arrington Jones↗ | RB |
| 1981 | 6 | 147 | Pete Kugler↗ | NT |
| 1981 | 8 | 203 | Garry White | RB |
| 1981 | 11 | 286 | Ronnie DeBose | TE |
| 1981 | 12 | 313 | Major Ogilvie | RB |
| 1981 | 12 | 322 | Joe Adams | QB |
| 1980 | 1 | 13 | Earl Cooper↗ | RB |
| 1980 | 1 | 20 | Jim Stuckey↗ | DE |
| 1980 | 2 | 39 | Keena Turner↗ | LB |
| 1980 | 3 | 65 | Jim Miller↗ | P |
| 1980 | 3 | 77 | Craig Puki↗ | LB |
| 1980 | 4 | 84 | Ricky Churchman↗ | DB |
| 1980 | 4 | 98 | David Hodge | LB |
| 1980 | 5 | 112 | Ken Times↗ | NT |
| 1980 | 6 | 139 | Herb Williams↗ | DB |
| 1980 | 8 | 210 | Bobby Leopold↗ | LB |
| 1980 | 9 | 237 | Dan Hartwig | QB |
| 1979 | 2 | 29 | James Owens↗ | RB |
| 1979 | 3 | 82 | Joe Montana HOF↗ | QB |
| 1979 | 5 | 111 | Tom Seabron↗ | LB |
| 1979 | 5 | 119 | Jerry Aldridge↗ | RB |
| 1979 | 6 | 138 | Ruben Vaughan↗ | DT |
| 1979 | 7 | 166 | Phil Francis↗ | RB |
| 1979 | 9 | 221 | Steve Hamilton | DT |
| 1979 | 10 | 249 | Dwight Clark↗ | WR |
| 1979 | 10 | 252 | Howard Ballage | DB |
| 1979 | 11 | 276 | Billy McBride | DB |
| 1978 | 1 | 7 | Ken MacAfee↗ | TE |
| 1978 | 1 | 24 | Dan Bunz↗ | LB |
| 1978 | 2 | 47 | Walt Downing↗ | G |
| 1978 | 3 | 79 | Ernie Hughes↗ | C |
| 1978 | 4 | 91 | Terry LeCount↗ | WR |
| 1978 | 5 | 127 | Archie Reese↗ | DE |
| 1978 | 5 | 133 | Bruce Threadgill↗ | DB |
| 1978 | 6 | 148 | Elliott Walker↗ | RB |
| 1978 | 7 | 175 | Fred Quillan↗ | C |
| 1978 | 9 | 229 | Herman Redden | DB |
| 1978 | 9 | 233 | Dean Moore↗ | LB |
| 1978 | 9 | 249 | Steve McDaniels | T |
| 1978 | 10 | 260 | Mike Connell↗ | P |
| 1978 | 11 | 287 | Willie McCray↗ | DE |
| 1978 | 12 | 314 | Dan Irons | T |
| 1977 | 3 | 65 | Elmo Boyd↗ | WR |
| 1977 | 4 | 100 | Stan Black↗ | DB |
| 1977 | 6 | 141 | Mike Burns↗ | DB |
| 1977 | 6 | 155 | Jim Harlan↗ | T |
| 1977 | 7 | 183 | Jim Van Wagner↗ | RB |
| 1977 | 9 | 239 | David Posey↗ | K |
| 1977 | 11 | 295 | Brian Billick | TE |
| 1977 | 12 | 323 | Scott Martin | G |
| 1976 | 2 | 42 | Randy Cross↗ | G |
| 1976 | 2 | 57 | Eddie Lewis↗ | DB |
| 1976 | 4 | 100 | Steve Rivera↗ | WR |
| 1976 | 5 | 140 | Tony Leonard↗ | DB |
| 1976 | 6 | 168 | Robert Pennywell↗ | LB |
| 1976 | 6 | 177 | Scott Bull↗ | QB |
| 1976 | 7 | 194 | Jay Chesley | DB |
| 1976 | 8 | 223 | John Ayers↗ | G |
| 1976 | 9 | 250 | Kenny Harrison↗ | WR |
| 1976 | 10 | 275 | Robin Ross | T |
| 1976 | 11 | 305 | Paul Hofer↗ | RB |
| 1976 | 12 | 332 | Gerald Loper | G |
| 1976 | 13 | 359 | Larry Brumfield | DB |
| 1976 | 14 | 389 | Johnny Miller↗ | G |
| 1976 | 15 | 416 | Howard Stidham↗ | LB |
| 1976 | 16 | 443 | Reggie Lewis↗ | DE |
| 1976 | 17 | 473 | Darryl Jenkins | RB |
| 1975 | 1 | 10 | Jimmy Webb↗ | DT |
| 1975 | 2 | 35 | Greg Collins↗ | LB |
| 1975 | 3 | 71 | Jeff Hart↗ | T |
| 1975 | 3 | 72 | Steve Mike-Mayer↗ | K |
| 1975 | 3 | 74 | Wayne Baker↗ | DT |
| 1975 | 4 | 85 | Cleveland Elam↗ | DT |
| 1975 | 4 | 87 | Frank Oliver↗ | DB |
| 1975 | 5 | 114 | Wayne Bullock | RB |
| 1975 | 8 | 191 | Preston Kendrick | LB |
| 1975 | 9 | 218 | James Johnson | DB |
| 1975 | 9 | 223 | Dan Natale | TE |
| 1975 | 9 | 230 | Caesar Douglas | T |
| 1975 | 10 | 243 | Donnie Layton | RB |
| 1975 | 11 | 270 | Gene Hernandez | DB |
| 1975 | 12 | 295 | Rick Worley | QB |
| 1975 | 13 | 322 | Dale Mitchell↗ | LB |
| 1975 | 14 | 347 | David Henson | WR |
| 1975 | 15 | 374 | Rich Lavin | TE |
| 1974 | 1 | 9 | Wilbur Jackson↗ | RB |
| 1974 | 1 | 10 | Bill Sandifer↗ | DT |
| 1974 | 2 | 35 | Keith Fahnhorst↗ | T |
| 1974 | 2 | 49 | Delvin Williams↗ | RB |
| 1974 | 4 | 83 | Clint Haslerig↗ | WR |
| 1974 | 4 | 90 | Sammy Johnson↗ | RB |
| 1974 | 6 | 138 | Mike Raines↗ | DT |
| 1974 | 7 | 166 | Kermit Johnson↗ | RB |
| 1974 | 8 | 191 | Jim Schnietz | G |
| 1974 | 9 | 216 | Manfred Moore↗ | RB |
| 1974 | 10 | 244 | Glen Gaspard | LB |
| 1974 | 11 | 269 | Greg Battle | DB |
| 1974 | 12 | 294 | Tom Hull↗ | LB |
| 1974 | 13 | 322 | Tom Owen↗ | QB |
| 1974 | 14 | 347 | Walt Williamson | DE |
| 1974 | 15 | 372 | Leonard Gray | TE |
| 1974 | 16 | 400 | Jack Conners | DB |
| 1974 | 17 | 425 | Levi Stanley | G |
| 1973 | 1 | 18 | Mike Holmes↗ | DB |
| 1973 | 2 | 41 | Willie Harper↗ | LB |
| 1973 | 5 | 112 | Mike Fulk | LB |
| 1973 | 5 | 122 | Ed Beverly↗ | WR |
| 1973 | 6 | 149 | Arthur Moore↗ | NT |
| 1973 | 7 | 174 | John Mitchell | LB |
| 1973 | 8 | 201 | Dave Atkins↗ | RB |
| 1973 | 9 | 226 | Roger Praetorius | RB |
| 1973 | 10 | 253 | Charlie Hunt↗ | LB |
| 1973 | 11 | 278 | Tom Dahlberg | RB |
| 1973 | 12 | 305 | Larry Pettus | T |
| 1973 | 13 | 330 | Alan Kelso | C |
| 1973 | 14 | 357 | Dennis Morrison↗ | QB |
| 1973 | 15 | 382 | Mike Bettiga↗ | WR |
| 1973 | 16 | 409 | Mike Oven | TE |
| 1973 | 17 | 434 | Bob Erickson | G |
| 1972 | 1 | 19 | Terry Beasley↗ | WR |
| 1972 | 2 | 28 | Ralph McGill↗ | DB |
| 1972 | 2 | 44 | Jean Barrett↗ | T |
| 1972 | 3 | 71 | Jubilee Dunbar↗ | WR |
| 1972 | 4 | 96 | Windlan Hall↗ | DB |
| 1972 | 5 | 123 | Mike Greene | LB |
| 1972 | 6 | 148 | Jackie Walker | DB |
| 1972 | 7 | 175 | Ed Hardy↗ | G |
| 1972 | 8 | 200 | Tom Wittum↗ | P |
| 1972 | 9 | 227 | Jerry Brown | DB |
| 1972 | 10 | 252 | Steve Williams↗ | DE |
| 1972 | 11 | 279 | Tom Laputka | DE |
| 1972 | 12 | 304 | Steve Setzler | DE |
| 1972 | 13 | 331 | Leon Pettigrew | T |
| 1972 | 14 | 356 | Eric Guthrie | QB |
| 1972 | 15 | 383 | Bob Maddox | DE |
| 1972 | 16 | 408 | Ron Davis↗ | G |
| 1972 | 17 | 435 | Ted Alexander | RB |
| 1971 | 1 | 23 | William Anderson↗ | DB |
| 1971 | 2 | 37 | Ernie Janet↗ | G |
| 1971 | 2 | 49 | Joe Orduna↗ | RB |
| 1971 | 3 | 55 | Sam Dickerson | WR |
| 1971 | 3 | 75 | Willie Parker↗ | C |
| 1971 | 4 | 101 | Tony Harris↗ | DB |
| 1971 | 5 | 114 | Dean Shaternick | T |
| 1971 | 5 | 122 | George Wells | LB |
| 1971 | 5 | 127 | Marty Huff↗ | LB |
| 1971 | 6 | 153 | Al Bresler | WR |
| 1971 | 7 | 179 | John Watson↗ | G |
| 1971 | 8 | 205 | Jim McCann↗ | P |
| 1971 | 9 | 231 | Therman Couch | LB |
| 1971 | 10 | 236 | Ron Cardo | RB |
| 1971 | 10 | 257 | Ernie Jennings | WR |
| 1971 | 11 | 283 | Joe Reed↗ | QB |
| 1971 | 12 | 309 | Jim Bunch | DT |
| 1971 | 13 | 335 | John Bullock | RB |
| 1971 | 14 | 361 | Bill Dunstan↗ | DT |
| 1971 | 15 | 387 | John Lennon | T |
| 1971 | 16 | 414 | Dave Pursell | DT |
| 1971 | 17 | 438 | Leroy Charlton | DB |
| 1970 | 1 | 9 | Cedrick Hardman↗ | DE |
| 1970 | 1 | 17 | Bruce Taylor↗ | DB |
| 1970 | 2 | 48 | John Isenbarger↗ | RB |
| 1970 | 4 | 87 | Vic Washington↗ | RB |
| 1970 | 5 | 113 | Gary McArthur | T |
| 1970 | 6 | 138 | Rusty Clark | QB |
| 1970 | 7 | 165 | Jim Strong↗ | RB |
| 1970 | 8 | 191 | Carter Campbell↗ | DE |
| 1970 | 9 | 217 | Preston Riley↗ | WR |
| 1970 | 10 | 243 | Larry Schreiber↗ | RB |
| 1970 | 11 | 269 | Dan Crockett | WR |
| 1970 | 12 | 295 | Bill Tant | T |
| 1970 | 13 | 321 | Jim Vanderslice | LB |
| 1970 | 14 | 347 | Jack King | G |
| 1970 | 15 | 373 | Dave Delsignore | WR |
| 1970 | 16 | 399 | Produs Perkins | DB |
| 1970 | 17 | 425 | Mike Culton | P |
| 1969 | 1 | 7 | Ted Kwalick↗ | TE |
| 1969 | 1 | 16 | Gene Washington↗ | WR |
| 1969 | 4 | 86 | Jim Sniadecki↗ | LB |
| 1969 | 4 | 94 | Gene Moore↗ | RB |
| 1969 | 5 | 120 | Earl Edwards↗ | DT |
| 1969 | 6 | 146 | Jimmy Thomas↗ | RB |
| 1969 | 7 | 172 | Steve Van Sinderen | T |
| 1969 | 8 | 198 | Mike Loper | T |
| 1969 | 9 | 224 | Hilton Crawford↗ | DB |
| 1969 | 10 | 250 | Dave Chapple↗ | P |
| 1969 | 11 | 276 | Willie Peake | T |
| 1969 | 12 | 302 | Jack O'Malley | T |
| 1969 | 13 | 328 | Paul Champlin | DB |
| 1969 | 14 | 354 | Tom Black | FL |
| 1969 | 15 | 380 | Gary Golden | DB |
| 1969 | 16 | 406 | Bob Hoskins↗ | DT |
| 1969 | 17 | 432 | Joe Rushing | LB |
| 1968 | 1 | 15 | Forrest Blue↗ | C |
| 1968 | 3 | 65 | Lance Olssen↗ | T |
| 1968 | 3 | 69 | Skip Vanderbundt↗ | LB |
| 1968 | 4 | 98 | Johnny Fuller↗ | DB |
| 1968 | 5 | 125 | Dwight Lee↗ | RB |
| 1968 | 6 | 141 | Lee Johnson↗ | WR |
| 1968 | 6 | 153 | Bill Belk↗ | DE |
| 1968 | 7 | 179 | Jerry Richardson | LB |
| 1968 | 8 | 206 | Charley Brown | T |
| 1968 | 8 | 207 | Tom Gray | FL |
| 1968 | 9 | 233 | Casey Boyett | E |
| 1968 | 10 | 261 | Tommy Hart↗ | DE |
| 1968 | 11 | 287 | Dennis Fitzgibbons | G |
| 1968 | 12 | 315 | Henry Johnson | QB |
| 1968 | 13 | 341 | Tom Mitrakos | C |
| 1968 | 14 | 369 | Alex Moore↗ | RB |
| 1968 | 15 | 395 | Clarence Spencer | FL |
| 1968 | 16 | 423 | Tom Rosenow | DT |
| 1968 | 17 | 449 | Dennis Patera↗ | K |
| 1967 | 1 | 3 | Steve Spurrier↗ | QB |
| 1967 | 1 | 11 | Cas Banaszek↗ | T |
| 1967 | 2 | 39 | Tom Holzer↗ | DE |
| 1967 | 3 | 62 | Frank Nunley↗ | LB |
| 1967 | 3 | 65 | Bill Tucker↗ | RB |
| 1967 | 4 | 91 | Wayne Trimble↗ | DB |
| 1967 | 6 | 145 | Doug Cunningham↗ | RB |
| 1967 | 7 | 170 | Milt Jackson | DB |
| 1967 | 8 | 198 | Walter Johnson↗ | DE |
| 1967 | 9 | 223 | Bob Briggs↗ | DE |
| 1967 | 10 | 248 | Chip Myers↗ | WR |
| 1967 | 11 | 276 | Ken Carmann | DT |
| 1967 | 12 | 301 | James Hall | LB |
| 1967 | 13 | 325 | Rich Gibbs | DB |
| 1967 | 14 | 354 | Dalton Leblanc | FL |
| 1967 | 15 | 379 | Clarence Spencer | FL |
| 1967 | 16 | 404 | Bart Templeman | C |
| 1967 | 17 | 432 | Danny Talbott | QB |
| 1966 | 1 | 11 | Stan Hindman↗ | DE |
| 1966 | 2 | 26 | Bob Windsor↗ | TE |
| 1966 | 3 | 37 | Al Randolph↗ | DB |
| 1966 | 3 | 41 | Dan Bland | DB |
| 1966 | 4 | 56 | Don Parker↗ | G |
| 1966 | 5 | 69 | Mel Phillips↗ | DB |
| 1966 | 5 | 71 | Steve Smith↗ | T |
| 1966 | 6 | 91 | Charlie Johnson↗ | DT |
| 1966 | 8 | 119 | Dick Witcher↗ | WR |
| 1966 | 9 | 133 | Kent Kramer↗ | TE |
| 1966 | 10 | 147 | Ronald Sbranti↗ | LB |
| 1966 | 11 | 166 | Preston Ridlehuber↗ | RB |
| 1966 | 12 | 180 | Lyle Loebach | T |
| 1966 | 13 | 194 | Jim Jackson↗ | DB |
| 1966 | 14 | 208 | Elmer Collett↗ | G |
| 1966 | 15 | 222 | Saint Saffold↗ | SE |
| 1966 | 16 | 241 | Jim LeClair↗ | QB |
| 1966 | 17 | 255 | Jim Breland | C |
| 1966 | 18 | 269 | Ron Parson | E |
| 1966 | 19 | 283 | Dick Fitzgerald | T |
| 1966 | 20 | 297 | Willie Walker | E |
| 1965 | 1 | 2 | Ken Willard↗ | RB |
| 1965 | 1 | 13 | George Donnelly↗ | DB |
| 1965 | 2 | 16 | Joe Cerne↗ | C |
| 1965 | 3 | 29 | Bob Schweickert↗ | QB |
| 1965 | 3 | 30 | Jim Norton↗ | DE |
| 1965 | 3 | 42 | Jack Chapple↗ | LB |
| 1965 | 4 | 44 | Larry Todd↗ | RB |
| 1965 | 5 | 58 | Dave McCormick↗ | T |
| 1965 | 9 | 114 | Wayne Swinford↗ | DB |
| 1965 | 10 | 128 | Bob Cappadona↗ | RB |
| 1965 | 11 | 142 | Steve Mass | T |
| 1965 | 12 | 156 | Dave Plump↗ | DB |
| 1965 | 13 | 170 | Gregg Schumacher↗ | DE |
| 1965 | 14 | 184 | Frank Andruski | HB |
| 1965 | 15 | 198 | Joe Pabian | T |
| 1965 | 16 | 212 | Dave Hettema↗ | T |
| 1965 | 17 | 226 | Len Frketich | E |
| 1965 | 18 | 240 | Leon Standridge | E |
| 1965 | 19 | 254 | Dale Ford | HB |
| 1965 | 20 | 268 | Dennis Duncan | B |
| 1964 | 1 | 1 | Dave Parks↗ | SE |
| 1964 | 2 | 15 | George Mira↗ | QB |
| 1964 | 3 | 29 | Dave Wilcox HOF↗ | LB |
| 1964 | 4 | 43 | Jim Wilson↗ | G |
| 1964 | 5 | 57 | Rudy Johnson↗ | HB |
| 1964 | 6 | 71 | Gary Lewis↗ | RB |
| 1964 | 7 | 85 | Hagood Clarke↗ | DB |
| 1964 | 8 | 99 | Bob Daugherty↗ | HB |
| 1964 | 8 | 102 | Bob Poole↗ | TE |
| 1964 | 9 | 113 | Howard Mudd↗ | G |
| 1964 | 10 | 127 | Fred Polser | T |
| 1964 | 11 | 141 | Dennis Almquist | G |
| 1964 | 12 | 155 | Jim Long | B |
| 1964 | 13 | 169 | Robert Brown↗ | DT |
| 1964 | 14 | 183 | Ed Beard↗ | LB |
| 1964 | 15 | 197 | Jim Griffin↗ | DE |
| 1964 | 16 | 211 | Cornell Gordon↗ | DB |
| 1964 | 17 | 225 | Ken Brusven | T |
| 1964 | 18 | 239 | Jerry Cole | E |
| 1964 | 19 | 253 | Larry Rawson | B |
| 1964 | 20 | 267 | Gene Baker | G |
| 1963 | 1 | 8 | Kermit Alexander Jr.↗ | DB |
| 1963 | 2 | 21 | Walt Rock↗ | T |
| 1963 | 3 | 36 | Don Lisbon↗ | HB |
| 1963 | 4 | 46 | Hatch Rosdahl↗ | DE |
| 1963 | 4 | 50 | Hugh Campbell | E |
| 1963 | 5 | 64 | Vern Burke↗ | SE |
| 1963 | 5 | 65 | Jim (Preacher) Pilot | B |
| 1963 | 5 | 66 | Gary Moeller | G |
| 1963 | 6 | 77 | Pat Emerick | G |
| 1963 | 7 | 92 | Ernest DeCourley | T |
| 1963 | 8 | 105 | Roger Locke | E |
| 1963 | 9 | 120 | John Maczuzak↗ | DT |
| 1963 | 10 | 133 | Dick Lopour | B |
| 1963 | 11 | 148 | Steve Shafer | B |
| 1963 | 12 | 161 | Bob Benton | T |
| 1963 | 13 | 176 | Dick Schulz | T |
| 1963 | 14 | 189 | Bill Tobin↗ | HB |
| 1963 | 15 | 204 | Oliver Ross | B |
| 1963 | 16 | 217 | Jim Bogdalek | T |
| 1963 | 17 | 232 | Ken Reed | G |
| 1963 | 18 | 245 | John Sellers | T |
| 1963 | 19 | 260 | Bob Price | G |
| 1963 | 20 | 273 | Don Davis | B |
| 1962 | 1 | 8 | Lance Alworth HOF↗ | FL |
| 1962 | 2 | 22 | Ed Pine↗ | LB |
| 1962 | 3 | 36 | Billy Ray Adams | FB |
| 1962 | 4 | 46 | Chuck Sieminski↗ | DT |
| 1962 | 4 | 50 | Floyd Dean↗ | LB |
| 1962 | 5 | 62 | Ted Woods | HB |
| 1962 | 5 | 64 | Mike Lind↗ | FB |
| 1962 | 6 | 71 | Keith Luhnow | B |
| 1962 | 6 | 76 | Jerry Brown | G |
| 1962 | 6 | 78 | Bill Winter | T |
| 1962 | 7 | 92 | John Burrell↗ | WR |
| 1962 | 8 | 106 | Jim Vollenweider↗ | HB |
| 1962 | 9 | 120 | Jim Roberts | T |
| 1962 | 10 | 134 | Regis Coustillac | G |
| 1962 | 11 | 148 | Larry Jepson | C |
| 1962 | 12 | 162 | Milt McPike | E |
| 1962 | 13 | 176 | George Pierovich | B |
| 1962 | 14 | 190 | Dick Easterly | B |
| 1962 | 15 | 204 | Ray Osbourne | T |
| 1962 | 16 | 218 | Ron Frank | T |
| 1962 | 17 | 232 | Wally Foltz | E |
| 1962 | 18 | 246 | Gary Brown | T |
| 1962 | 19 | 260 | Bob Burton | T |
| 1962 | 20 | 274 | Roger McFarland | B |
| 1961 | 1 | 6 | Jimmy Johnson HOF↗ | DB |
| 1961 | 1 | 9 | Bernie Casey↗ | HB |
| 1961 | 1 | 11 | Billy Kilmer↗ | QB |
| 1961 | 2 | 24 | Roland Lakes↗ | DT |
| 1961 | 3 | 37 | Bill Cooper↗ | FB |
| 1961 | 4 | 47 | Aaron Thomas↗ | TE |
| 1961 | 4 | 52 | Dale Messer↗ | HB |
| 1961 | 5 | 58 | Clark Miller↗ | DE |
| 1961 | 5 | 65 | Bob McCreary↗ | T |
| 1961 | 6 | 80 | Mike McClellan↗ | DB |
| 1961 | 7 | 93 | Ray Purdin | B |
| 1961 | 8 | 108 | Neill Plumley | T |
| 1961 | 9 | 118 | Leon Donohue↗ | G |
| 1961 | 9 | 121 | Everisto Nino | T |
| 1961 | 10 | 136 | Paul Hynes↗ | DB |
| 1961 | 11 | 149 | Tony Parrilli | G |
| 1961 | 12 | 164 | Donald Coffey↗ | WR |
| 1961 | 13 | 174 | Tommy Hackler | E |
| 1961 | 13 | 177 | Julius Fincke | T |
| 1961 | 14 | 192 | Bill Worrell | T |
| 1961 | 15 | 205 | Bob Sams | T |
| 1961 | 16 | 220 | Charley Fuller↗ | HB |
| 1961 | 17 | 233 | Tom Jewell | T |
| 1961 | 18 | 248 | Kay McFarland↗ | WR |
| 1961 | 19 | 261 | Tom Simpson | T |
| 1961 | 20 | 276 | Jerry Peery | G |
| 1960 | 1 | 11 | Monty Stickles↗ | TE |
| 1960 | 2 | 16 | Mike Magac↗ | G |
| 1960 | 2 | 22 | Carl Kammerer↗ | DE |
| 1960 | 3 | 35 | Rod Breedlove↗ | LB |
| 1960 | 4 | 46 | Ray Norton↗ | HB |
| 1960 | 5 | 59 | Len Rohde↗ | T |
| 1960 | 6 | 70 | Lee Murchison↗ | WR |
| 1960 | 7 | 83 | Bob Waters↗ | QB |
| 1960 | 8 | 88 | Bill Mathis↗ | FB |
| 1960 | 8 | 94 | Max Fugler | C |
| 1960 | 9 | 107 | Bobby Wasden | E |
| 1960 | 10 | 118 | Mel Branch↗ | DE |
| 1960 | 11 | 126 | Ed Pitts | T |
| 1960 | 11 | 131 | Ernie Hansen | C |
| 1960 | 12 | 142 | Jim Williams | G |
| 1960 | 13 | 155 | Dean Hinshaw | T |
| 1960 | 14 | 166 | Gary Campbell | B |
| 1960 | 15 | 179 | Mike Dowdle↗ | LB |
| 1960 | 16 | 190 | Jim Heineke | T |
| 1960 | 17 | 203 | Goose Gonsoulin↗ | DB |
| 1960 | 18 | 214 | Carl Robinson | T |
| 1960 | 19 | 227 | Bobby Pate | B |
| 1960 | 20 | 238 | Jim Woodward | T |
| 1959 | 1 | 5 | Dave Baker↗ | DB |
| 1959 | 1 | 8 | Dan James↗ | T |
| 1959 | 2 | 17 | Bob Harrison↗ | LB |
| 1959 | 3 | 29 | Eddie Dove↗ | DB |
| 1959 | 4 | 41 | Monte Clark↗ | T |
| 1959 | 5 | 54 | Frank Geremia | T |
| 1959 | 6 | 66 | Tony Bavaro | T |
| 1959 | 7 | 74 | Don Rogers↗ | C |
| 1959 | 7 | 78 | Daniel Colchico↗ | DE |
| 1959 | 8 | 90 | Lew Aken | E |
| 1959 | 9 | 102 | Bobby Joe Green↗ | P |
| 1959 | 10 | 114 | Bronko Nagurski | T |
| 1959 | 11 | 126 | Jack Hayes | B |
| 1959 | 12 | 138 | Bill Korutz | C |
| 1959 | 13 | 150 | Bill Lopasky↗ | G |
| 1959 | 14 | 162 | Mike Dukes↗ | LB |
| 1959 | 15 | 174 | Joe Belland | B |
| 1959 | 16 | 186 | Bob Cook | B |
| 1959 | 17 | 198 | Jerome Jurczak | C |
| 1959 | 18 | 210 | Jack Cowley | T |
| 1959 | 19 | 222 | Tom Osborne↗ | WR |
| 1959 | 20 | 234 | Toby Deese | T |
| 1959 | 21 | 246 | Luther Carr | B |
| 1959 | 22 | 258 | Burnio McQueen | E |
| 1959 | 23 | 270 | Bruce Dollahan | T |
| 1959 | 24 | 282 | Craig Chudy | E |
| 1959 | 25 | 294 | Roy Gee | G |
| 1959 | 26 | 306 | Ed Young | E |
| 1959 | 27 | 318 | Mel Semenko | T |
| 1959 | 28 | 330 | Mike McCluskey | B |
| 1959 | 29 | 342 | Jack Bolton | T |
| 1959 | 30 | 354 | Bob Carter | T |
| 1958 | 1 | 8 | James Pace↗ | HB |
| 1958 | 1 | 9 | Charlie Krueger↗ | DT |
| 1958 | 2 | 22 | Bob Newman | B |
| 1958 | 3 | 33 | Bob Hoppe | B |
| 1958 | 4 | 46 | John Varone | B |
| 1958 | 5 | 59 | Billy Atkins↗ | DB |
| 1958 | 6 | 71 | Henry Schmidt↗ | DT |
| 1958 | 8 | 87 | Leon Burton↗ | HB |
| 1958 | 8 | 95 | Ron Mills | B |
| 1958 | 9 | 107 | George Troutman | T |
| 1958 | 10 | 119 | Vel Heckman | T |
| 1958 | 11 | 131 | Hogan Wharton↗ | G |
| 1958 | 12 | 143 | Pete Williams | T |
| 1958 | 13 | 151 | Jim Yore | B |
| 1958 | 13 | 155 | Hal Dukes | E |
| 1958 | 14 | 167 | Max Fields | B |
| 1958 | 16 | 191 | George Shirkey↗ | DT |
| 1958 | 17 | 203 | John Wittenborn↗ | G |
| 1958 | 18 | 215 | Dennit Morris↗ | LB |
| 1958 | 19 | 227 | Ronnie Mushatt | C |
| 1958 | 20 | 239 | Jerry Mertens↗ | DB |
| 1958 | 21 | 251 | Don Christian | B |
| 1958 | 22 | 263 | Bruce Hartman | T |
| 1958 | 23 | 275 | Larry Fields | B |
| 1958 | 24 | 287 | Dee Mackey↗ | E |
| 1958 | 25 | 299 | Bill Kaczmarek | C |
| 1958 | 26 | 311 | Hillard Hill | E |
| 1958 | 27 | 323 | Bob Witucki | E |
| 1958 | 28 | 335 | Garland Warren | C |
| 1958 | 29 | 347 | Herman Hodges | B |
| 1958 | 30 | 358 | Ted Stahura | T |
| 1957 | 1 | 3 | John Brodie↗ | QB |
| 1957 | 2 | 15 | Abe Woodson↗ | DB |
| 1957 | 4 | 39 | Jimmy Ridlon↗ | DB |
| 1957 | 4 | 46 | Mike Sandusky↗ | G |
| 1957 | 5 | 56 | Karl Rubke↗ | LB |
| 1957 | 6 | 62 | Bill Rhodes | B |
| 1957 | 6 | 68 | Jim Hunter | B |
| 1957 | 7 | 80 | Fred Dugan↗ | E |
| 1957 | 8 | 92 | Ernie Pitts | E |
| 1957 | 9 | 104 | Charlie Brueckman↗ | LB |
| 1957 | 10 | 116 | Jerry Hurst | E |
| 1957 | 11 | 128 | Tommy Davis↗ | K |
| 1957 | 12 | 140 | Fred Sington | T |
| 1957 | 13 | 152 | Charley Mackey | E |
| 1957 | 14 | 164 | Ron Warzeka↗ | DT |
| 1957 | 15 | 176 | Earl Kaiser | B |
| 1957 | 16 | 188 | Vic Kristopaitis | B |
| 1957 | 17 | 200 | Dave Kuhn | C |
| 1957 | 18 | 212 | Dick Guy | G |
| 1957 | 19 | 224 | Gene Babb↗ | LB |
| 1957 | 20 | 236 | Sid DeLoatch | G |
| 1957 | 21 | 248 | Fred Wilcox | B |
| 1957 | 22 | 260 | Paul Tripp | T |
| 1957 | 23 | 272 | John Thomas↗ | G |
| 1957 | 24 | 284 | John Ladner | E |
| 1957 | 25 | 296 | Ray Meyer | B |
| 1957 | 26 | 308 | Tom Topping | T |
| 1957 | 27 | 320 | Don Vicic | B |
| 1957 | 28 | 332 | Bill Curtis | B |
| 1957 | 29 | 344 | Vern Hallbeck | B |
| 1957 | 30 | 355 | George Parks | B |
| 1956 | 1 | 2 | Earl Morrall↗ | QB |
| 1956 | 2 | 15 | Bruce Bosley↗ | C |
| 1956 | 3 | 26 | Bill Herchman↗ | DT |
| 1956 | 4 | 40 | Frank Pajaczkowski | B |
| 1956 | 6 | 64 | Tony Sardisco↗ | G |
| 1956 | 7 | 75 | Larry Barnes↗ | FB |
| 1956 | 8 | 88 | Charlie Smith↗ | DE |
| 1956 | 9 | 99 | Jim Cox | E |
| 1956 | 10 | 112 | Jerry Zaleski | B |
| 1956 | 11 | 123 | Stew Pell | T |
| 1956 | 12 | 136 | Roger Swedberg | T |
| 1956 | 13 | 147 | Ralph Moody | B |
| 1956 | 14 | 160 | R.C. Owens↗ | HB |
| 1956 | 15 | 171 | Reed Henderson | T |
| 1956 | 15 | 172 | Gene Boyd | B |
| 1956 | 16 | 184 | George Herring↗ | QB |
| 1956 | 17 | 195 | Dick Weiss | T |
| 1956 | 18 | 208 | Bill Yelverton↗ | DE |
| 1956 | 19 | 219 | Pete Arrigoni | B |
| 1956 | 20 | 232 | Bob Scarbrough | C |
| 1956 | 21 | 243 | L.C. Joyner↗ | HB |
| 1956 | 22 | 256 | Clarence Wessman | E |
| 1956 | 23 | 267 | Mike Monroe | B |
| 1956 | 24 | 280 | Ed Wallace | T |
| 1956 | 25 | 291 | Paul Goad↗ | FB |
| 1956 | 26 | 304 | Rommie Loudd↗ | LB |
| 1956 | 27 | 315 | Jerry Gustafson | QB |
| 1956 | 28 | 328 | Jerry Drew | B |
| 1956 | 29 | 339 | Dean Benson | G |
| 1956 | 30 | 351 | Bob Mitchell | T |
| 1955 | 1 | 10 | Dicky Moegle↗ | DB |
| 1955 | 2 | 21 | Frank Morze↗ | C |
| 1955 | 3 | 34 | Carroll Hardy↗ | HB |
| 1955 | 4 | 45 | Matt Hazeltine↗ | LB |
| 1955 | 5 | 58 | Eldred Kraemer↗ | G |
| 1955 | 6 | 69 | Bobby Luna↗ | DB |
| 1955 | 7 | 82 | Johnny Dean | B |
| 1955 | 8 | 93 | Freddie Meyers | B |
| 1955 | 9 | 106 | Fred Preziosio | T |
| 1955 | 10 | 117 | Ron Ashbacker | E |
| 1955 | 11 | 130 | Rudy Rotella | E |
| 1955 | 12 | 141 | Lou Palatella↗ | G |
| 1955 | 13 | 154 | Richie Gaskell | E |
| 1955 | 14 | 165 | Nick McKeithan | B |
| 1955 | 15 | 178 | Burdette Hess | G |
| 1955 | 16 | 189 | Jim Hall | E |
| 1955 | 17 | 202 | Bob Newton | G |
| 1955 | 18 | 213 | Ron Pheister | C |
| 1955 | 19 | 226 | John Garzoli | T |
| 1955 | 20 | 237 | Glen Dyer | B |
| 1955 | 21 | 250 | George Maderos↗ | DB |
| 1955 | 22 | 261 | Pete Vann | QB |
| 1955 | 23 | 274 | Tom Gunnari | E |
| 1955 | 24 | 285 | Bob Heaston | G |
| 1955 | 25 | 298 | Dewey Wade | E |
| 1955 | 26 | 309 | Johnny Kerr | E |
| 1955 | 27 | 322 | Dick Shockey | B |
| 1955 | 28 | 333 | Don Sanders | B |
| 1955 | 29 | 346 | Otto Kneidinger | T |
| 1955 | 30 | 356 | Bob Gongola | B |
| 1954 | 1 | 11 | Bernie Faloney | B |
| 1954 | 2 | 23 | Leo Rucka↗ | LB |
| 1954 | 3 | 35 | Steve Korcheck | C |
| 1954 | 4 | 47 | Charlie Boxold | B |
| 1954 | 5 | 55 | Bob Hantla↗ | G |
| 1954 | 5 | 59 | Frank Mincevich | G |
| 1954 | 6 | 71 | Floyd Sagely↗ | DB |
| 1954 | 7 | 83 | Sid Youngelman↗ | DT |
| 1954 | 9 | 107 | Ted Connolly↗ | G |
| 1954 | 11 | 131 | John Skocko | E |
| 1954 | 12 | 143 | Hal Easterwood | C |
| 1954 | 13 | 155 | Morgan Williams | G |
| 1954 | 14 | 167 | Sammy Williams | B |
| 1954 | 15 | 171 | Ed Gossage | T |
| 1954 | 15 | 179 | Sam Palumbo | G |
| 1954 | 16 | 191 | Bobby Fiveash | B |
| 1954 | 17 | 203 | Carl Kautz | T |
| 1954 | 18 | 215 | Morris Kay | E |
| 1954 | 19 | 227 | Bob Edmiston | T |
| 1954 | 20 | 239 | Frank Dipietro | B |
| 1954 | 21 | 251 | Howard Alsup | T |
| 1954 | 22 | 263 | Ralph Reynolds | B |
| 1954 | 23 | 275 | LeRoy Fenstemaker | B |
| 1954 | 24 | 287 | Jerry Daniels | T |
| 1954 | 25 | 299 | John Platt | B |
| 1954 | 26 | 311 | Pete Bello | C |
| 1954 | 27 | 323 | Gayford Baker | G |
| 1954 | 28 | 335 | Bob Garbrecht | B |
| 1954 | 29 | 347 | Ted Dunn | B |
| 1954 | 30 | 359 | Don Folks | E |
| 1953 | 1 | 1 | Harry Babcock↗ | E |
| 1953 | 1 | 10 | Tom Stolhandske↗ | LB |
| 1953 | 2 | 21 | George Morris↗ | C |
| 1953 | 3 | 32 | Bob St. Clair HOF↗ | T |
| 1953 | 4 | 47 | Ed Fullerton↗ | DB |
| 1953 | 5 | 58 | Hal Miller↗ | T |
| 1953 | 7 | 83 | Paul Carr↗ | DB |
| 1953 | 8 | 94 | Doug Hogland↗ | G |
| 1953 | 9 | 105 | Hal Ledyard↗ | QB |
| 1953 | 10 | 119 | Pete Brown↗ | C |
| 1953 | 11 | 130 | Al Charlton | B |
| 1953 | 12 | 141 | Carson (Red) Leach | G |
| 1953 | 13 | 155 | Bill Earley | B |
| 1953 | 14 | 166 | Tom Fletcher | B |
| 1953 | 15 | 177 | Charley Genthner | T |
| 1953 | 16 | 191 | Fred Durig | E |
| 1953 | 17 | 202 | Hugh Latham | T |
| 1953 | 18 | 213 | Stan Wacholz | E |
| 1953 | 19 | 227 | King DuClos | T |
| 1953 | 20 | 238 | Ray Huizinga | T |
| 1953 | 21 | 249 | Ken Bahnsen↗ | FB |
| 1953 | 22 | 263 | Laverne Robbins | G |
| 1953 | 23 | 274 | Travis Hunt | T |
| 1953 | 24 | 285 | Ed Morgan | B |
| 1953 | 25 | 299 | Ernie Stockert | E |
| 1953 | 26 | 310 | Harley Cooper | B |
| 1953 | 27 | 321 | Ralph McLeod | E |
| 1953 | 28 | 335 | Tom Novikoff | B |
| 1953 | 29 | 346 | Don Stillwell | E |
| 1952 | 1 | 9 | Hugh McElhenny HOF↗ | HB |
| 1952 | 2 | 22 | Bob Toneff↗ | DT |
| 1952 | 3 | 27 | Gene Shannon | B |
| 1952 | 3 | 33 | Billy Tidwell↗ | HB |
| 1952 | 4 | 46 | Marion Campbell↗ | DE |
| 1952 | 5 | 57 | Pat O'Donahue↗ | DE |
| 1952 | 6 | 70 | Jim Beasley | C |
| 1952 | 7 | 81 | Don Robison | B |
| 1952 | 8 | 94 | Jerry Smith↗ | G |
| 1952 | 9 | 105 | Glen Christian | B |
| 1952 | 10 | 118 | Carl West | B |
| 1952 | 11 | 129 | J.D. Kimmel↗ | DT |
| 1952 | 12 | 142 | Fred Snyder | E |
| 1952 | 13 | 153 | Rudy Yeager | T |
| 1952 | 14 | 166 | Frank Simon | E |
| 1952 | 15 | 177 | Haldo Norman | E |
| 1952 | 16 | 190 | Bob Meyers↗ | HB |
| 1952 | 17 | 201 | Al Baldock | E |
| 1952 | 18 | 214 | Bill Carey | E |
| 1952 | 20 | 238 | Jess Yates | E |
| 1952 | 21 | 249 | Gene Offield | C |
| 1952 | 22 | 262 | Jim Cozad | T |
| 1952 | 23 | 273 | Bill Glazier | E |
| 1952 | 24 | 286 | Ralph Kreuger | T |
| 1952 | 25 | 297 | Bud Laughlin↗ | FB |
| 1952 | 26 | 310 | Dick Kane | G |
| 1952 | 27 | 321 | Waldo Schaaf | T |
| 1952 | 28 | 334 | Joe Palumbo | G |
| 1952 | 29 | 345 | Chuck Mosher | E |
| 1952 | 30 | 358 | Dick Patrick | C |
| 1951 | 1 | 3 | Y.A. Tittle HOF↗ | QB |
| 1951 | 2 | 17 | Pete Schabarum↗ | HB |
| 1951 | 3 | 28 | Billy Mixon↗ | HB |
| 1951 | 5 | 53 | Dick Steere↗ | G |
| 1951 | 5 | 54 | Al Carapella↗ | DT |
| 1951 | 6 | 64 | Bishop Strickland↗ | FB |
| 1951 | 7 | 75 | Dick Forbes | E |
| 1951 | 8 | 89 | Joe Arenas↗ | HB |
| 1951 | 9 | 100 | Bruce Van Alstyne | E |
| 1951 | 10 | 112 | Nick Feher↗ | G |
| 1951 | 11 | 126 | Bill Jessup↗ | E |
| 1951 | 12 | 137 | Jim Monachino↗ | HB |
| 1951 | 13 | 148 | Dick Harvin | E |
| 1951 | 14 | 162 | Rex Berry↗ | DB |
| 1951 | 15 | 173 | Dave Sparks↗ | G |
| 1951 | 16 | 184 | Bob White↗ | HB |
| 1951 | 17 | 198 | Art Michalik↗ | MG |
| 1951 | 18 | 209 | Jim Murphy | T |
| 1951 | 19 | 220 | John Phillips | B |
| 1951 | 20 | 234 | Al Tate | T |
| 1951 | 21 | 245 | Hardy Brown↗ | B |
| 1951 | 22 | 256 | Dwight Winslow | B |
| 1951 | 23 | 270 | Wally Brunswald | B |
| 1951 | 24 | 281 | Tom Kingsford | B |
| 1951 | 25 | 292 | Mike Peterson | E |
| 1951 | 26 | 306 | Keith Carpenter | T |
| 1951 | 27 | 317 | Ray Lung | G |
| 1951 | 28 | 328 | Jack Rohan | B |
| 1951 | 29 | 342 | S.P. Garnett | T |
| 1951 | 30 | 353 | Jerry Faske | B |
| 1950 | 1 | 11 | Leo Nomellini HOF↗ | DT |
| 1950 | 2 | 23 | Don Campora↗ | T |
| 1950 | 3 | 37 | Ray Collins↗ | DT |
| 1950 | 4 | 49 | Morris Bailey | E |
| 1950 | 5 | 63 | Harry Kane | C |
| 1950 | 6 | 75 | Don Van Pool | E |
| 1950 | 7 | 89 | Lindy Berry | B |
| 1950 | 8 | 101 | Ellery Williams↗ | E |
| 1950 | 9 | 115 | Pete Zinaich | B |
| 1950 | 10 | 127 | Bob Celeri↗ | QB |
| 1950 | 11 | 141 | Harley Dow↗ | G |
| 1950 | 12 | 153 | Don Burke↗ | LB |
| 1950 | 13 | 167 | Lou (Bimbo) Cecconi | B |
| 1950 | 14 | 179 | Tom Payne | E |
| 1950 | 15 | 193 | Leo Crampsey | E |
| 1950 | 16 | 205 | Charlie Shaw↗ | G |
| 1950 | 17 | 219 | Cliff Van Meter | B |
| 1950 | 18 | 231 | Ralph Genito | B |
| 1950 | 19 | 245 | Forest Klein | G |
| 1950 | 20 | 257 | Jack Nix↗ | E |
| 1950 | 21 | 271 | Guerin Alker | C |
| 1950 | 22 | 283 | Billy Wilson↗ | E |
| 1950 | 23 | 297 | Jim (Froggy) Williams | E |
| 1950 | 24 | 309 | Bill Wyman | T |
| 1950 | 25 | 323 | Bob Dunn | G |
| 1950 | 26 | 335 | Jim Powers↗ | DB |
| 1950 | 27 | 349 | Ken Johnson | G |
| 1950 | 28 | 361 | Charley Hall | B |
| 1950 | 29 | 375 | Bob Whelan | B |
| 1950 | 30 | 387 | Bob Stillwell | E |
| No results found. | ||||
Coach History
| Kyle Shanahan | 2017-2025 | 9 | 149 | 82 | 67 | 0 | .550 | 14 | 9 | 5 |
| Chip Kelly | 2016 | 1 | 16 | 2 | 14 | 0 | .125 | 0 | 0 | 0 |
| Jim Tomsula | 2010, 2015 | 2 | 17 | 6 | 11 | 0 | .353 | 0 | 0 | 0 |
| Jim Harbaugh | 2011-2014 | 4 | 64 | 44 | 19 | 1 | .695 | 8 | 5 | 3 |
| Mike Singletary | 2008-2010 | 3 | 40 | 18 | 22 | 0 | .450 | 0 | 0 | 0 |
| Mike Nolan | 2005-2008 | 4 | 55 | 18 | 37 | 0 | .327 | 0 | 0 | 0 |
| Dennis Erickson | 2003-2004 | 2 | 32 | 9 | 23 | 0 | .281 | 0 | 0 | 0 |
| Steve Mariucci | 1997-2002 | 6 | 96 | 57 | 39 | 0 | .594 | 7 | 3 | 4 |
| George Seifert | 1989-1996 | 8 | 128 | 98 | 30 | 0 | .766 | 15 | 10 | 5 |
| Bill Walsh | 1979-1988 | 10 | 152 | 92 | 59 | 1 | .609 | 14 | 10 | 4 |
| Fred O'Connor | 1978 | 1 | 7 | 1 | 6 | 0 | .143 | 0 | 0 | 0 |
| Pete McCulley | 1978 | 1 | 9 | 1 | 8 | 0 | .111 | 0 | 0 | 0 |
| Ken Meyer | 1977 | 1 | 14 | 5 | 9 | 0 | .357 | 0 | 0 | 0 |
| Monte Clark | 1976 | 1 | 14 | 8 | 6 | 0 | .571 | 0 | 0 | 0 |
| Dick Nolan | 1968-1975 | 8 | 112 | 54 | 53 | 5 | .504 | 5 | 2 | 3 |
| Jack Christiansen | 1963-1967 | 5 | 67 | 26 | 38 | 3 | .410 | 0 | 0 | 0 |
| Red Hickey | 1959-1963 | 5 | 55 | 27 | 27 | 1 | .500 | 0 | 0 | 0 |
| Frankie Albert | 1956-1958 | 3 | 36 | 19 | 16 | 1 | .542 | 1 | 0 | 1 |
| Red Strader | 1955 | 1 | 12 | 4 | 8 | 0 | .333 | 0 | 0 | 0 |
| Buck Shaw | 1946-1954 | 9 | 114 | 71 | 39 | 4 | .640 | 2 | 1 | 1 |
| No results found. | ||||||||||
| Total | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
